Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H20N2O10.2Na.2H |
| Molecular Weight | 424.3114 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H+].[H+].[Na+].[Na+].[O-]C(=O)CN(CCOCCOCCN(CC([O-])=O)CC([O-])=O)CC([O-])=O
InChI
InChIKey=PSNPATLUBMVVTM-UHFFFAOYSA-L
InChI=1S/C14H24N2O10.2Na/c17-11(18)7-15(8-12(19)20)1-3-25-5-6-26-4-2-16(9-13(21)22)10-14(23)24;;/h1-10H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24);;/q;2*+1/p-2
| Molecular Formula | Na |
| Molecular Weight | 22.98976928 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C14H22N2O10 |
| Molecular Weight | 378.3319 |
| Charge | -2 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/29075867
Sources: https://www.ncbi.nlm.nih.gov/pubmed/29075867
Egtazic acid or EGTA is widely used for biological research as a chelating agent relatively more specific for calcium ions.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: calcium ion Sources: https://www.ncbi.nlm.nih.gov/pubmed/12669884 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
PubMed
| Title | Date | PubMed |
|---|---|---|
| Cystic fibrosis pathogens activate Ca2+-dependent mitogen-activated protein kinase signaling pathways in airway epithelial cells. | 2001-06-01 |
|
| Hormone-specific combinations of isoforms of adenylyl cyclase and phosphodiesterase in the rat liver. | 2001-05-05 |
|
| The Ca2+-sensing receptor activates cytosolic phospholipase A2 via a Gqalpha -dependent ERK-independent pathway. | 2001-04-27 |
|
| Purification and characterization of a plasmin-like protease from Tenodera sinensis (Chinese mantis). | 2001-04-27 |
|
| Vinpocetine-induced stimulation of calcium-activated potassium currents in rat pituitary GH3 cells. | 2001-04-01 |
|
| Biological activity of soluble CD100. I. The extracellular region of CD100 is released from the surface of T lymphocytes by regulated proteolysis. | 2001-04-01 |
|
| Site-specific calcium-dependent proteolysis of neuronal protein GAP-43. | 2001-04 |
|
| Heterogeneous increases of cytoplasmic calcium: distinct effects on down-regulation of cell surface sodium channels and sodium channel subunit mRNA levels. | 2001-04 |
|
| The effects of exogenous calcium buffers on the systolic calcium transient in rat ventricular myocytes. | 2001-04 |
|
| E-cadherin-mediated cell contact prevents apoptosis of spontaneously immortalized granulosa cells by regulating Akt kinase activity. | 2001-04 |
|
| Mechanical compression influences intracellular Ca2+ signaling in chondrocytes seeded in agarose constructs. | 2001-04 |
|
| Changes in cardiac contractile function and myocardial. | 2001-04 |
|
| Angiotensin II stimulates cardiac L-type Ca(2+) current by a Ca(2+)- and protein kinase C-dependent mechanism. | 2001-04 |
|
| Calcium buffering and protection from excitotoxic cell death by exogenous calbindin-D28k in HEK 293 cells. | 2001-04 |
|
| Calcium requirement for efficient phagocytosis by Dictyostelium discoideum. | 2001-04 |
|
| Cytosolic Ca(2+) signal is involved in regulating UV-induced apoptosis in hela cells. | 2001-03-23 |
|
| EGTA enhancement of adenovirus-mediated gene transfer to mouse tracheal epithelium in vivo. | 2001-03-20 |
|
| Calcium-dependent structural changes in scallop heavy meromyosin. | 2001-03-16 |
|
| Role of Fas and granule exocytosis pathways in tumor-infiltrating T lymphocyte-induced apoptosis of autologous human lung-carcinoma cells. | 2001-03-15 |
|
| Monodansylcadaverine inhibits cytotoxicity of Vibrio parahaemolyticus thermostable direct hemolysin on cultured rat embryonic fibroblast cells. | 2001-03-15 |
|
| Transmitter release modulation by intracellular Ca2+ buffers in facilitating and depressing nerve terminals of pyramidal cells in layer 2/3 of the rat neocortex indicates a target cell-specific difference in presynaptic calcium dynamics. | 2001-03-15 |
|
| Increased Ca2+ buffering enhances Ca2+-dependent process. | 2001-03-15 |
|
| Differential regulation of transmitter release by presynaptic and glial Ca2+ internal stores at the neuromuscular synapse. | 2001-03-15 |
|
| A23187 causes release of inositol phosphates from cultured rat Kupffer cells. | 2001-03-09 |
|
| Metabolic fate of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine by human spermatozoa: biosynthesis and biodegradation. | 2001-03-02 |
|
| Evidence of calcium influx across the plasma membrane depends upon the initial rise of cytosolic calcium with activation of IP(3) in rat enterocytes by heat-stable enterotoxin of Vibrio cholerae non-O1. | 2001-03-01 |
|
| Contribution of postsynaptic Ca2+ to the induction of post-tetanic potentiation in the neural circuit for siphon withdrawal in Aplysia. | 2001-03-01 |
|
| Characterization of the deg-3/des-2 receptor: a nicotinic acetylcholine receptor that mutates to cause neuronal degeneration. | 2001-03 |
|
| Calcium-magnesium interactions in pancreatic acinar cells. | 2001-03 |
|
| The unusual gradient elution for reversed phase HPLC of a strong chelator as an active drug substance. | 2001-03 |
|
| Intraplatelet calcium levels in patients with acute renal failure before and after the administration of loop diuretics. | 2001-03 |
|
| The role of calcium signaling in early axonal and dendritic morphogenesis of rat cerebral cortex neurons under non-stimulated growth conditions. | 2001-02-28 |
|
| The stimulation of MAP kinase by 1,25(OH)(2)-vitamin D(3) in skeletal muscle cells is mediated by protein kinase C and calcium. | 2001-02-28 |
|
| Pharmacological interventions of cyanide-induced cytotoxicity and DNA damage in isolated rat thymocytes and their protective efficacy in vivo. | 2001-02-03 |
|
| Characterization of adenylyl cyclases in cultured human granulosa cells. | 2001-02 |
|
| Characterization of oxyntic glands isolated from the rat gastric mucosa. | 2001-02 |
|
| Caffeine stores and dopamine differentially require Ca(2+) channels in goldfish somatotropes. | 2001-02 |
|
| Role of elementary Ca(2+) puffs in generating repetitive Ca(2+) oscillations. | 2001-01-15 |
|
| Characterization of the ryanodine receptor-Ca2+ release channel from the thoracic tissues of the lepidopteran insect Heliothis virescens. | 2001-01-15 |
|
| Beta1 integrin activation on human neutrophils promotes beta2 integrin-mediated adhesion to fibronectin. | 2001-01 |
|
| Hydrogen peroxide induces apoptosis of chondrocytes; involvement of calcium ion and extracellular signal-regulated protein kinase. | 2001-01 |
|
| [Transition metals and nitric oxide production in human endothelial cells]. | 2001-01 |
|
| CD63 associates with the alphaIIb beta3 integrin-CD9 complex on the surface of activated platelets. | 2001-01 |
|
| Effects of Mannheimia haemolytica leukotoxin on apoptosis and oncosis of bovine neutrophils. | 2001-01 |
|
| Calcium-induced conformational changes in Leishmania infantum kinetoplastid membrane protein-11. | 2001-01 |
|
| Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth. | 2001 |
|
| Local regulation of anion secretion by pituitary adenylate cyclase-activating polypeptide in human colonic T84 cells. | 2001 |
|
| Maitotoxin-induced membrane blebbing and cell death in bovine aortic endothelial cells. | 2001 |
|
| Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin. | 2001 |
|
| Intercellular calcium signaling and flash photolysis of caged compounds. A sensitive method to evaluate gap junctional coupling. | 2001 |
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/29075867
Curator's Comment: EGTA, a calcium chelator, inhibited C. glutamicum growth at relatively lower concentrations compared with other Gram-positive bacteria. Simultaneous addition of EGTA and lysozyme resulted in cell lysis, whereas addition of these reagents separately had no such effect.
Unknown
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:20:41 GMT 2025
by
admin
on
Mon Mar 31 21:20:41 GMT 2025
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| Record UNII |
7T6F42A6GN
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| Record Status |
Validated (UNII)
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| Record Version |
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