COLUMBAMINE

COC1=C(O)C=C2C(CC[N+]3=C2C=C4C=CC(OC)=C(OC)C4=C3)=C1

InChIKey=YYFOFDHQVIODOQ-UHFFFAOYSA-O

InChI=1S/C20H19NO4/c1-23-18-5-4-12-8-16-14-10-17(22)19(24-2)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,8-11H,6-7H2,1-3H3/p+1

PubMed

Title	Date	PubMed
Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.	1991 Jan-Feb	1710653
Molecular cloning of columbamine O-methyltransferase from cultured Coptis japonica cells.	2002 Nov	12423366
Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids.	2007 Jul 16	17634120
[Studies on chemical constituents in the anti-myocardial ischemia effective fraction of Corydalis yanhusuo].	2008 Nov	19260272
Quaternary alkaloids of Argemone mexicana.	2010 Feb	20645832
Anti-inflammatory and anti-nociceptive activities of compounds from Tinospora sagittata (Oliv.) Gagnep.	2010 Jul	20661706
Metabolic diversification of benzylisoquinoline alkaloid biosynthesis through the introduction of a branch pathway in Eschscholzia californica.	2010 Jun	20427510
Alkaloids from Fissistigma latifolium (Dunal) Merr.	2010 Jun 24	20657378
Metabolites of protoberberine alkaloids in human urine following oral administration of Coptidis Rhizoma decoction.	2010 Nov	20549593
Dig1 protects against cell death provoked by glyphosate-based herbicides in human liver cell lines.	2010 Oct 27	20979644
Columbamine suppresses the proliferation and neovascularization of metastatic osteosarcoma U2OS cells with low cytotoxicity.	2012 Dec 17	23124089

Name

Type

Language

COLUMBAMINE

Common Name

English

COLUMBAMINE [MI]

Common Name

English

5,6-DIHYDRO-2-HYDROXY-3,9,10-TRIMETHOXYDIBENZO(A,G)QUINOLIZINIUM

Systematic Name

English

DIBENZO(A,G)QUINOLIZINIUM, 5,6-DIHYDRO-2-HYDROXY-3,9,10-TRIMETHOXY-

Systematic Name

English

7,8,13,13.ALPHA.-TETRADEHYDRO-2-HYDROXY-3,9,10-TRIMETHOXYBERBINIUM

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID80189766