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Details

Stereochemistry ABSOLUTE
Molecular Formula C24H32N6O11.ClH
Molecular Weight 617.005
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TAVILERMIDE HYDROCHLORIDE

SMILES

Cl.NCCCC[C@@H]1NC(=O)[C@H](CCC(O)=O)NC(=O)C2=C(OCC[C@H](NC1=O)C(=O)NCC(O)=O)C=CC(=C2)[N+]([O-])=O

InChI

InChIKey=IHXKKAUOKMTRIF-FRKSIBALSA-N
InChI=1S/C24H32N6O11.ClH/c25-9-2-1-3-15-23(37)29-17(22(36)26-12-20(33)34)8-10-41-18-6-4-13(30(39)40)11-14(18)21(35)27-16(24(38)28-15)5-7-19(31)32;/h4,6,11,15-17H,1-3,5,7-10,12,25H2,(H,26,36)(H,27,35)(H,28,38)(H,29,37)(H,31,32)(H,33,34);1H/t15-,16-,17-;/m0./s1

HIDE SMILES / InChI

Description

Tavilermide (also known as MIM-D3) was developed as a tyrosine kinase TrkA receptor agonist for the treatment of patients with dry eye. The drug was studied in phase III clinical trial in treating the signs and symptoms of dry eye. In addition, was assumed that tavilermide could be studied for glaucoma.

Originator

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
An NGF mimetic, MIM-D3, stimulates conjunctival cell glycoconjugate secretion and demonstrates therapeutic efficacy in a rat model of dry eye.
2011 Oct

Sample Use Guides

In Vivo Use Guide
A total of 150 dry eye patients were randomized 1:1:1 to study medication (1% MIM-D3 (TAVILERMIDE), 5% MIM-D3, or placebo) and dosed twice daily (BID) for 28 days.
Route of Administration: Other
Name Type Language
TAVILERMIDE HYDROCHLORIDE
USAN   WHO-DD  
USAN  
Official Name English
3-(4R,7S,10S)-7-(4-AMINOBUTYL)-4-((CARBOXYMETHYL)AMINO)CARBONYL)-14-NITRO-6,9,12-TRIOXO-3,4,5,6,7,8,9,10,11,12-DECAHYDRO-2H-1,5,8,11-BENZOXATRIAZACYCLOTETRADECIN-10-YL) PROPANOIC ACID, HYDROCHLORIDE
Common Name English
GLYCINE, N-(2-HYDROXY-5-NITROBENZOYL)-L-.ALPHA.-GLUTAMYL-L-LYSYL-L-HOMOSERYL-, CYCLIC (1->3)-ETHER HYDROCHLORIDE
Common Name English
TAVILERMIDE HYDROCHLORIDE [USAN]
Common Name English
D-3 HYDROCHLORIDE
Common Name English
MPS-429
Code English
MIM D-3 HYDROCHLORIDE
Code English
MIM-D3 HYDROCHLORIDE
Code English
Tavilermide hydrochloride [WHO-DD]
Common Name English
Code System Code Type Description
NCI_THESAURUS
C167042
Created by admin on Sat Dec 16 05:40:18 GMT 2023 , Edited by admin on Sat Dec 16 05:40:18 GMT 2023
PRIMARY
ChEMBL
CHEMBL3544981
Created by admin on Sat Dec 16 05:40:18 GMT 2023 , Edited by admin on Sat Dec 16 05:40:18 GMT 2023
PRIMARY
PUBCHEM
91667662
Created by admin on Sat Dec 16 05:40:18 GMT 2023 , Edited by admin on Sat Dec 16 05:40:18 GMT 2023
PRIMARY
USAN
BC-127
Created by admin on Sat Dec 16 05:40:18 GMT 2023 , Edited by admin on Sat Dec 16 05:40:18 GMT 2023
PRIMARY
SMS_ID
300000044521
Created by admin on Sat Dec 16 05:40:18 GMT 2023 , Edited by admin on Sat Dec 16 05:40:18 GMT 2023
PRIMARY
CAS
1460213-99-3
Created by admin on Sat Dec 16 05:40:18 GMT 2023 , Edited by admin on Sat Dec 16 05:40:18 GMT 2023
PRIMARY
FDA UNII
7Q2C23X6YH
Created by admin on Sat Dec 16 05:40:18 GMT 2023 , Edited by admin on Sat Dec 16 05:40:18 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of TAVILERMIDE
NIH
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