Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C71H110N24O18S.2ClH |
| Molecular Weight | 1692.77 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 12 / 12 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CN=CN1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]4CCC(=O)N4)C(C)C)C(N)=O
InChI
InChIKey=VMJYQBARVAILCT-RDVJJKDBSA-N
InChI=1S/C71H110N24O18S.2ClH/c1-34(2)24-47(92-62(105)43(14-11-22-79-71(76)77)89-64(107)45(15-18-52(72)96)90-63(106)44-17-20-55(99)85-44)61(104)81-31-56(100)87-51(28-54(74)98)69(112)91-46(16-19-53(73)97)65(108)94-49(26-38-29-80-41-13-10-9-12-40(38)41)66(109)84-37(7)60(103)95-58(36(5)6)70(113)82-32-57(101)86-50(27-39-30-78-33-83-39)68(111)93-48(25-35(3)4)67(110)88-42(59(75)102)21-23-114-8;;/h9-10,12-13,29-30,33-37,42-51,58,80H,11,14-28,31-32H2,1-8H3,(H2,72,96)(H2,73,97)(H2,74,98)(H2,75,102)(H,78,83)(H,81,104)(H,82,113)(H,84,109)(H,85,99)(H,86,101)(H,87,100)(H,88,110)(H,89,107)(H,90,106)(H,91,112)(H,92,105)(H,93,111)(H,94,108)(H,95,103)(H4,76,77,79);2*1H/t37-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,58-;;/m0../s1
Bombesin (BN), a neuropeptide that originally was purified from the skin of the European frog (Bombina bombina). It has many biological effects including hormone release, stimulation of pancreatic enzyme secretion, gallbladder contraction and bronchoconstriction. Bombesin is a highly specific marker of neuroendocrine differentiation and thus a valuable tumor marker. It activates three different G-protein-coupled receptors known as BBR1, -2, and -3.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Regulation and signaling of human bombesin receptors and their biological effects. | 2009-02 |
|
| Bombesin-like peptides: studies on food intake and social behaviour with receptor knock-out mice. | 2000-11 |
|
| The effect of bombesin, cholecystokinin, gastrin, and their antagonists on proliferation of pancreatic cancer cell lines. | 1999-12 |
|
| Bombesin in human neuroendocrine (NE) neoplasms. | 1985 |
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| Code System | Code | Type | Description | ||
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DBSALT002057
Created by
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33910-70-2
Created by
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m2602
Created by
admin on Mon Mar 31 21:30:05 GMT 2025 , Edited by admin on Mon Mar 31 21:30:05 GMT 2025
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PRIMARY | Merck Index | ||
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DTXSID10187533
Created by
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7LN1X0A80V
Created by
admin on Mon Mar 31 21:30:05 GMT 2025 , Edited by admin on Mon Mar 31 21:30:05 GMT 2025
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71587120
Created by
admin on Mon Mar 31 21:30:05 GMT 2025 , Edited by admin on Mon Mar 31 21:30:05 GMT 2025
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PRIMARY |
SUBSTANCE RECORD
