Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C71H110N24O18S.2ClH |
| Molecular Weight | 1692.77 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 12 / 12 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CN=CN1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC2=CNC3=CC=CC=C23)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]4CCC(=O)N4)C(C)C)C(N)=O
InChI
InChIKey=VMJYQBARVAILCT-RDVJJKDBSA-N
InChI=1S/C71H110N24O18S.2ClH/c1-34(2)24-47(92-62(105)43(14-11-22-79-71(76)77)89-64(107)45(15-18-52(72)96)90-63(106)44-17-20-55(99)85-44)61(104)81-31-56(100)87-51(28-54(74)98)69(112)91-46(16-19-53(73)97)65(108)94-49(26-38-29-80-41-13-10-9-12-40(38)41)66(109)84-37(7)60(103)95-58(36(5)6)70(113)82-32-57(101)86-50(27-39-30-78-33-83-39)68(111)93-48(25-35(3)4)67(110)88-42(59(75)102)21-23-114-8;;/h9-10,12-13,29-30,33-37,42-51,58,80H,11,14-28,31-32H2,1-8H3,(H2,72,96)(H2,73,97)(H2,74,98)(H2,75,102)(H,78,83)(H,81,104)(H,82,113)(H,84,109)(H,85,99)(H,86,101)(H,87,100)(H,88,110)(H,89,107)(H,90,106)(H,91,112)(H,92,105)(H,93,111)(H,94,108)(H,95,103)(H4,76,77,79);2*1H/t37-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,58-;;/m0../s1
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C71H110N24O18S |
| Molecular Weight | 1619.848 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 12 / 12 |
| E/Z Centers | 8 |
| Optical Activity | UNSPECIFIED |
Bombesin (BN), a neuropeptide that originally was purified from the skin of the European frog (Bombina bombina). It has many biological effects including hormone release, stimulation of pancreatic enzyme secretion, gallbladder contraction and bronchoconstriction. Bombesin is a highly specific marker of neuroendocrine differentiation and thus a valuable tumor marker. It activates three different G-protein-coupled receptors known as BBR1, -2, and -3.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Bombesin in human neuroendocrine (NE) neoplasms. | 1985 |
|
| The effect of bombesin, cholecystokinin, gastrin, and their antagonists on proliferation of pancreatic cancer cell lines. | 1999 Dec |
|
| Bombesin-like peptides: studies on food intake and social behaviour with receptor knock-out mice. | 2000 Nov |
|
| Regulation and signaling of human bombesin receptors and their biological effects. | 2009 Feb |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 05:31:01 GMT 2023
by
admin
on
Sat Dec 16 05:31:01 GMT 2023
|
| Record UNII |
7LN1X0A80V
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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DBSALT002057
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33910-70-2
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m2602
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admin on Sat Dec 16 05:31:01 GMT 2023 , Edited by admin on Sat Dec 16 05:31:01 GMT 2023
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PRIMARY | Merck Index | ||
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DTXSID10187533
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7LN1X0A80V
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admin on Sat Dec 16 05:31:01 GMT 2023 , Edited by admin on Sat Dec 16 05:31:01 GMT 2023
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71587120
Created by
admin on Sat Dec 16 05:31:01 GMT 2023 , Edited by admin on Sat Dec 16 05:31:01 GMT 2023
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