CARBIPHENE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C28H34N2O2.ClH
Molecular Weight	467.043
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCOC(C(=O)N(C)CCN(C)CCC1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=DQPNQXUUCWOWCK-UHFFFAOYSA-N

InChI=1S/C28H34N2O2.ClH/c1-4-32-28(25-16-10-6-11-17-25,26-18-12-7-13-19-26)27(31)30(3)23-22-29(2)21-20-24-14-8-5-9-15-24;/h5-19H,4,20-23H2,1-3H3;1H

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4921303 | https://www.ncbi.nlm.nih.gov/pubmed/5223213 | https://www.ncbi.nlm.nih.gov/pubmed/14157083 | http://digitalcommons.unmc.edu/cgi/viewcontent.cgi?article=1037&context=mdtheses

Carbiphene (etomide, SQ 10,269) is a nonnarcotic analgesic agent for the relief of pain. SQ 10,269 is considered to be a non-addicting analgesic agent indicated for the relief of all types of pain, including post-operative pain and pain associated with chronic and recurrent diseases.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
GABAergic synapse 4 Target ID: map04727 Sources: https://link.springer.com/article/10.1023/A%3A1026666419725	Modulator 846

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 619 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4921303 https://www.ncbi.nlm.nih.gov/pubmed/5223213 https://www.ncbi.nlm.nih.gov/pubmed/14157083	Primary		Approved 8583	Bandol Approved Use Bandol is used to treat minor aches and pain and to reduce fever. It may also help treat pain from mild forms of arthritis.
Arthritis 87 Sources: http://digitalcommons.unmc.edu/cgi/viewcontent.cgi?article=1037&context=mdtheses	Palliative		Approved 8583	Bandol Approved Use Bandol is used to treat minor aches and pain and to reduce fever. It may also help treat pain from mild forms of arthritis.

Doses

Dose	Population	Adverse events
150 mg 2 times / day multiple, oral Studied dose Dose: 150 mg, 2 times / day Route: oral Route: multiple Dose: 150 mg, 2 times / day Sources: https://digitalcommons.unmc.edu/cgi/viewcontent.cgi?referer=&httpsredir=1&article=1037&context=mdtheses	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: FED Sources: https://digitalcommons.unmc.edu/cgi/viewcontent.cgi?referer=&httpsredir=1&article=1037&context=mdtheses	Sources: https://digitalcommons.unmc.edu/cgi/viewcontent.cgi?referer=&httpsredir=1&article=1037&context=mdtheses

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
inhibitor 2252	inhibitor 2438	inhibitor 2507

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer

Drug as perpetrator

Target	Modality	Activity
CYP2D6 2546	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/10080#section=BioAssay-Results	inconclusive [IC50 26.837 uM]
CYP3A4 2633	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/10080#section=BioAssay-Results	yes [IC50 1.345 uM]
CYP2C9 2497	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/10080#section=BioAssay-Results	yes [IC50 6.0081 uM]

PubMed

Title	Date	PubMed
High survival and treatment success sustained after two and three years of first-line ART for children in Cambodia.	2010-03-21	20302672
The analgesic effect of carbiphene hydrochloride.	1970-11	4921303

Patents

Sample Use Guides

In Vivo Use Guide

Treatment of arthritis: 150 mg, twice daily.

Route of Administration: Oral

In Vitro Use Guide

Carbiphene potently inhibited [35S]TBPS binding with IC50 value of 12 uM.

Name

Type

Language

BANDOL

Preferred Name

English

CARBIPHENE HYDROCHLORIDE

Official Name

English

SQ-10269

Code

English

CARBIPHENE HYDROCHLORIDE [MI]

Common Name

English

CARBIFENE HYDROCHLORIDE

Common Name

English

CARBIPHENE HYDROCHLORIDE [USAN]

Common Name

English

CARBIPHENE HCL

Common Name

English

BENZENEACETAMIDE, .ALPHA.-ETHOXY-N-METHYL-N-(2-(METHYL(2-PHENYLETHYL)AMINO)ETHYL)-.ALPHA.-PHENYL-, MONOHYDROCHLORIDE

Common Name

English

SQ 10,269

Code

English

NSC-106959

Code

English

Carbiphene hydrochloride [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C241