CARBIPHENE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C28H34N2O2.ClH
Molecular Weight	467.043
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCOC(C(=O)N(C)CCN(C)CCC1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=DQPNQXUUCWOWCK-UHFFFAOYSA-N

InChI=1S/C28H34N2O2.ClH/c1-4-32-28(25-16-10-6-11-17-25,26-18-12-7-13-19-26)27(31)30(3)23-22-29(2)21-20-24-14-8-5-9-15-24;/h5-19H,4,20-23H2,1-3H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C28H34N2O2
Molecular Weight	430.5818
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4921303 | https://www.ncbi.nlm.nih.gov/pubmed/5223213 | https://www.ncbi.nlm.nih.gov/pubmed/14157083 | http://digitalcommons.unmc.edu/cgi/viewcontent.cgi?article=1037&context=mdtheses

Carbiphene (etomide, SQ 10,269) is a nonnarcotic analgesic agent for the relief of pain. SQ 10,269 is considered to be a non-addicting analgesic agent indicated for the relief of all types of pain, including post-operative pain and pain associated with chronic and recurrent diseases.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
GABAergic synapse 4 Target ID: map04727 Sources: https://link.springer.com/article/10.1023/A%3A1026666419725	Modulator 828

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4921303 https://www.ncbi.nlm.nih.gov/pubmed/5223213 https://www.ncbi.nlm.nih.gov/pubmed/14157083	Primary		Approved 8429	Bandol Approved Use Bandol is used to treat minor aches and pain and to reduce fever. It may also help treat pain from mild forms of arthritis.
Arthritis 89 Sources: http://digitalcommons.unmc.edu/cgi/viewcontent.cgi?article=1037&context=mdtheses	Palliative		Approved 8429	Bandol Approved Use Bandol is used to treat minor aches and pain and to reduce fever. It may also help treat pain from mild forms of arthritis.

PubMed

Title	Date	PubMed
The analgesic effect of carbiphene hydrochloride.	1970 Nov	4921303
High survival and treatment success sustained after two and three years of first-line ART for children in Cambodia.	2010 Mar 21	20302672

Patents

Sample Use Guides

In Vivo Use Guide

Treatment of arthritis: 150 mg, twice daily.

Route of Administration: Oral

In Vitro Use Guide

Carbiphene potently inhibited [35S]TBPS binding with IC50 value of 12 uM.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:10:13 GMT 2023` Edited by `admin` on `Fri Dec 15 15:10:13 GMT 2023`
Record UNII	7L93SJ2K9A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CARBIPHENE HYDROCHLORIDE

Official Name

English

SQ-10269

Code

English

CARBIPHENE HYDROCHLORIDE [MI]

Common Name

English

CARBIFENE HYDROCHLORIDE

Common Name

English

CARBIPHENE HYDROCHLORIDE [USAN]

Common Name

English

CARBIPHENE HCL

Common Name

English

BENZENEACETAMIDE, .ALPHA.-ETHOXY-N-METHYL-N-(2-(METHYL(2-PHENYLETHYL)AMINO)ETHYL)-.ALPHA.-PHENYL-, MONOHYDROCHLORIDE

Common Name

English

SQ 10,269

Code

English

BANDOL

Brand Name

English

NSC-106959

Code

English

Carbiphene hydrochloride [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C241