SULFATE ION

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	O4S
Molecular Weight	96.063
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	-2

SHOW SMILES / InChI

Structure Search

SMILES

[O-]S([O-])(=O)=O

InChI

InChIKey=QAOWNCQODCNURD-UHFFFAOYSA-L

InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2

HIDE SMILES / InChI

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022372s004lbledt.pdf | https://www.webmd.com/drugs/2/drug-154631/suprep-bowel-prep-kit-oral/details

SULFATE (as sodium sulfate, potassium sulfate, and magnesium sulfate) is a component of SUPREP Bowel Prep Kit. It is an osmotic laxative indicated for cleansing of the colon in preparation for colonoscopy in adults. Sulfate salts provide sulfate anions, which are poorly absorbed. The osmotic effect of unabsorbed sulfate anions and the associated cations causes water to be retained within the gastrointestinal tract. SUPREP Bowel Prep Kit, when ingested with a large volume of water, produces copious watery diarrhea.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Bowel Cleanser 7 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022372s004lbledt.pdf	Palliative		Approved 8429	SUPREP Bowel Prep Kit Approved Use SUPREP Bowel Prep Kit is an osmotic laxative indicated for cleansing of the colon in preparation for colonoscopy in adults. Launch Date 2010

PubMed

Title	Date	PubMed
Dehydroepiandrosterone, dehydroepiandrosterone sulphate and cardiovascular disease.	1996 Sep	8943798
Heparan sulphate.	1997 May	9251237
Structure-activity relationship of heparan sulphate.	1997 Nov	9449976
Heparan sulphate proteoglycan and wound healing in skin.	1997 Nov	9422978
Magnesium sulphate for preventing preterm birth in threatened preterm labour.	2002	12519550
[Skin patch test with nickel sulphate--an attempt of broader interpretation of the results].	2002 Aug	12420348
Dermatan sulphate as an antithrombotic drug.	2002 Sep-Dec	13679662
Magnesium sulphate and other anticonvulsants for women with pre-eclampsia.	2003	12804383
Hepatocyte growth factor/scatter factor and its interaction with heparan sulphate and dermatan sulphate.	2003 Apr	12653636
Chondroitin sulphate proteoglycans in the central nervous system: changes and synthesis after injury.	2003 Apr	12653631
Heparan sulphate N-sulphotransferase activity: reaction mechanism and substrate recognition.	2003 Apr	12653630
Intravenous magnesium sulphate in acute myocardial infarction--is the answer "MAGIC"?	2003 Mar	12735485
Are low dehydroepiandrosterone sulphate levels predictive for cardiovascular diseases? A review of prospective and retrospective studies.	2003 Oct	14609305
The SLC13 gene family of sodium sulphate/carboxylate cotransporters.	2004 Feb	12915942
Epidemiology of 377 patients with chemical burns in Guangdong province.	2004 Sep	15302423
A meta-analysis on intravenous magnesium sulphate for treating acute asthma.	2005 Jan	15613519
Chondroitin sulphate: antioxidant properties and beneficial effects.	2006 Dec	17168807
Heparan sulphate proteoglycans and viral vectors : ally or foe?	2006 Feb	16475944
Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment.	2006 Jun	16709185
The role of heparan sulphate proteoglycans in angiogenesis.	2006 Jun	16709184
Insights into the role of heparan sulphate in fibroblast growth factor signalling.	2006 Jun	16709182
Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors.	2006 Jun	16709175
Dietary acidification enhances phosphorus digestibility but decreases H+/K+-ATPase expression in rainbow trout.	2006 Oct	16985189
Cholesterol sulfate as a potential inhibitor of hepatitis C virus NS3 helicase.	2014 Apr	23432541

Patents

Sample Use Guides

In Vivo Use Guide

Split-Dose (2-Day) Regimen: The evening before colonoscopy: dilute one bottle with water to a total volume of 16 oz. (up to the fill line) and drink the entire amount. Drink 32 ounces of water over the next hour. Next morning: repeat both steps using the second bottle. Complete preparation at least 2 hours before colonoscopy or as directed by a physician.

Route of Administration: Oral

Name

Type

Language

SULFATE ION

Common Name

English

SULFATE(2-)

Common Name

English

SULPHATE

Systematic Name

English

SULPHATE ION

Common Name

English

SULFATE

Systematic Name

English

SULPHATE(2-)

Common Name

English

SULFATE [VANDF]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C597