ACEXAMIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H15NO3
Molecular Weight	173.2096
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)NCCCCCC(O)=O

InChI

InChIKey=WDSCBUNMANHPFH-UHFFFAOYSA-N

InChI=1S/C8H15NO3/c1-7(10)9-6-4-2-3-5-8(11)12/h2-6H2,1H3,(H,9,10)(H,11,12)

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Description
Sources: https://www.rlsnet.ru/mnn_index_id_1901.htm
Curator's Comment: The description was created based on several sources, including https://www.drugs.com/international/acexamic-acid.html | https://www.ncbi.nlm.nih.gov/pubmed/18353035 | https://www.ncbi.nlm.nih.gov/pubmed/6159453 | https://www.ncbi.nlm.nih.gov/pubmed/19470000

Acexamic acid (N-acetyl-amino-6-hexanoic acid) is a drug used as a cicatrization helper. Some studies show that the acexamic acid prevents the formation the connective inflamed tissue and enables its healing. The association from acexamic acid with zinc, zinc acexamate, has been used in the treatment of gastric and duodenal ulcer and in the prevention of gastric ulcer induced by nonsteroidal anti-inflammatory drugs.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Wounds and injuries 3 Sources: https://www.rlsnet.ru/mnn_index_id_1901.htm	Curative		Approved 8429	Acemin ointment Approved Use Long-lasting non-healing wounds, skin and mucous burns, chronic traumatic osteomyelitis, closed and long-lasting incomplete fractures of bones, prevention of hyper-scarring, acceleration of the formation of a postoperative cosmetic scar, acceleration of engraftment of auto- and homotransplants.
Osteomyelitis 4 Sources: https://www.rlsnet.ru/mnn_index_id_1901.htm	Curative		Approved 8429	Acemin ointment Approved Use Long-lasting non-healing wounds, skin and mucous burns, chronic traumatic osteomyelitis, closed and long-lasting incomplete fractures of bones, prevention of hyper-scarring, acceleration of the formation of a postoperative cosmetic scar, acceleration of engraftment of auto- and homotransplants.

PubMed

Title	Date	PubMed
Alteration in serum and bone component findings induced in streptozotocin-diabetic rats is restored by zinc acexamate.	2003 Dec	14612972
Enhancement of albumin expression in bone tissues with healing rat fractures.	2003 May 15	12704798
Preventive effect of zinc acexamate administration in streptozotocin-diabetic rats: Restoration of bone loss.	2003 Nov	14533005
Topical treatment of peritoneal catheter-related exit-site granuloma with acetamidohexanoic acid combined with gentamicin.	2006 Jul-Aug	16881348
Nuclear magnetic resonance (NMR) solution structure, dynamics, and binding properties of the kringle IV type 8 module of apolipoprotein(a).	2007 Feb 20	17263558
[Nickel and magnesium effects in the rat kidney, treated with acid retinoic. Comparative study].	2007 Jul-Sep	18293710
Effect of zinc on gene expression in osteoblastic MC3T3-E1 cells: enhancement of Runx2, OPG, and regucalcin mRNA expressions.	2008 May	18327666
Pharmacokinetics and first-pass effects of epsilon-acetamidocaproic acid after administration of zinc acexamate in rats.	2010 Jul	20518623
Influence of cyclodextrin complexation with NSAIDs on NSAID/cold stress-induced gastric ulceration in rats.	2010 Jul 5	20617127
Role of nutritional zinc in the prevention of osteoporosis.	2010 May	20035439
Performance of human immunostimulating agents in the improvement of fish cytogenetic preparations.	2010 Sep 14	20845306

Patents

Sample Use Guides

In Vivo Use Guide

Outer: 5% ointment is applied to the disinfected wound surface daily. The course of treatment is from 10 to 30 days.

Route of Administration: Topical

In Vitro Use Guide

The mouse fibroblast cell line (NCTC Clone L 929) was maintained as stock culture in a minimum essential medium (MEM) supplemented with 10% calf serum and 200 i.u./ml G penicillin and 100 pg/d streptomycin. Cultures for growth studies were established by inoculating 7 X l0^4 cells in 2 ml medium in 35-mm plastic tissue culture dishes. They were maintained for 24 h to obtain a good attachment, then incubated in 5% calf serum medium supplemented or not with the drugs tested. Acexamic acid increased the growth rate of L 929 when used at a concentration of 0.001%

Name

Type

Language

ACEXAMIC ACID

Official Name

English

ACEMIN

Common Name

English

ACETAMIDOCAPROIC ACID

Official Name

English

6-(ACETYLAMINO)HEXANOIC ACID

Systematic Name

English

N-ACETYL-6-AMINOHEXANOIC ACID

Systematic Name

English

HEXANOIC ACID, 6-ACETAMIDO-

Common Name

English

CY-153

Code

English

6-ACETAMIDOCAPROIC ACID

Systematic Name

English

Acexamic acid [WHO-DD]

Common Name

English

ACEXAMIC ACID [MART.]

Common Name

English

ACETAMIDOCAPROIC ACID [INCI]

Common Name

English

HEXANOIC ACID, 6-(ACETYLAMINO)-

Common Name

English

ACETAMINOCAPROIC ACID

Systematic Name

English

NSC-12945

Code

English

acexamic acid [INN]

Common Name

English

.EPSILON.-ACETAMIDOCAPROIC ACID

Systematic Name

English

N-ACETYL-.EPSILON.-AMINOCAPROIC ACID

Systematic Name

English

6-ACETAMIDOHEXANOIC ACID

Systematic Name

English

CY 153

Code

English

.EPSILON.-ACETAMIDOCAPROIC ACID [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257