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Details

Stereochemistry ACHIRAL
Molecular Formula C8H15NO3
Molecular Weight 173.2096
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ACEXAMIC ACID

SMILES

CC(=O)NCCCCCC(O)=O

InChI

InChIKey=WDSCBUNMANHPFH-UHFFFAOYSA-N
InChI=1S/C8H15NO3/c1-7(10)9-6-4-2-3-5-8(11)12/h2-6H2,1H3,(H,9,10)(H,11,12)

HIDE SMILES / InChI

Description

Acexamic acid (N-acetyl-amino-6-hexanoic acid) is a drug used as a cicatrization helper. Some studies show that the acexamic acid prevents the formation the connective inflamed tissue and enables its healing. The association from acexamic acid with zinc, zinc acexamate, has been used in the treatment of gastric and duodenal ulcer and in the prevention of gastric ulcer induced by nonsteroidal anti-inflammatory drugs.

Originator

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Acemin ointment
Primary
Acemin ointment
PubMed

PubMed

TitleDatePubMed
Increase in bone growth factors with healing rat fractures: the enhancing effect of zinc.
2001 Oct
Alteration in serum and bone component findings induced in streptozotocin-diabetic rats is restored by zinc acexamate.
2003 Dec
Great increase in bone 66 kDa protein and osteocalcin at later stages with healing rat fractures: effect of zinc treatment.
2003 Feb
Enhancement of albumin expression in bone tissues with healing rat fractures.
2003 May 15
Preventive effect of zinc acexamate administration in streptozotocin-diabetic rats: Restoration of bone loss.
2003 Nov
Topical treatment of peritoneal catheter-related exit-site granuloma with acetamidohexanoic acid combined with gentamicin.
2006 Jul-Aug
Nuclear magnetic resonance (NMR) solution structure, dynamics, and binding properties of the kringle IV type 8 module of apolipoprotein(a).
2007 Feb 20
[Nickel and magnesium effects in the rat kidney, treated with acid retinoic. Comparative study].
2007 Jul-Sep
Allergic contact dermatitis to acexamic acid.
2008 Apr
Effect of zinc on gene expression in osteoblastic MC3T3-E1 cells: enhancement of Runx2, OPG, and regucalcin mRNA expressions.
2008 May
Pharmacokinetics and first-pass effects of epsilon-acetamidocaproic acid after administration of zinc acexamate in rats.
2010 Jul
Influence of cyclodextrin complexation with NSAIDs on NSAID/cold stress-induced gastric ulceration in rats.
2010 Jul 5
Role of nutritional zinc in the prevention of osteoporosis.
2010 May
Performance of human immunostimulating agents in the improvement of fish cytogenetic preparations.
2010 Sep 14
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Outer: 5% ointment is applied to the disinfected wound surface daily. The course of treatment is from 10 to 30 days.
Route of Administration: Topical
In Vitro Use Guide
The mouse fibroblast cell line (NCTC Clone L 929) was maintained as stock culture in a minimum essential medium (MEM) supplemented with 10% calf serum and 200 i.u./ml G penicillin and 100 pg/d streptomycin. Cultures for growth studies were established by inoculating 7 X l0^4 cells in 2 ml medium in 35-mm plastic tissue culture dishes. They were maintained for 24 h to obtain a good attachment, then incubated in 5% calf serum medium supplemented or not with the drugs tested. Acexamic acid increased the growth rate of L 929 when used at a concentration of 0.001%
Name Type Language
ACEXAMIC ACID
INN   MART.   WHO-DD  
INN  
Official Name English
ACEMIN
Common Name English
ACETAMIDOCAPROIC ACID
INCI  
INCI  
Official Name English
6-(ACETYLAMINO)HEXANOIC ACID
Systematic Name English
N-ACETYL-6-AMINOHEXANOIC ACID
Systematic Name English
HEXANOIC ACID, 6-ACETAMIDO-
Common Name English
CY-153
Code English
6-ACETAMIDOCAPROIC ACID
Systematic Name English
ACEXAMIC ACID [MART.]
Common Name English
ACETAMIDOCAPROIC ACID [INCI]
Common Name English
HEXANOIC ACID, 6-(ACETYLAMINO)-
Common Name English
ACETAMINOCAPROIC ACID
Systematic Name English
NSC-12945
Code English
ACEXAMIC ACID [INN]
Common Name English
.EPSILON.-ACETAMIDOCAPROIC ACID
MI  
Systematic Name English
N-ACETYL-.EPSILON.-AMINOCAPROIC ACID
Systematic Name English
6-ACETAMIDOHEXANOIC ACID
Systematic Name English
ACEXAMIC ACID [WHO-DD]
Common Name English
CY 153
Code English
.EPSILON.-ACETAMIDOCAPROIC ACID [MI]
Common Name English
Code System Code Type Description
EPA CompTox
57-08-9
Created by admin on Tue Mar 06 12:07:02 UTC 2018 , Edited by admin on Tue Mar 06 12:07:02 UTC 2018
PRIMARY
PUBCHEM
2005
Created by admin on Tue Mar 06 12:07:02 UTC 2018 , Edited by admin on Tue Mar 06 12:07:02 UTC 2018
PRIMARY
ChEMBL
CHEMBL2105922
Created by admin on Tue Mar 06 12:07:02 UTC 2018 , Edited by admin on Tue Mar 06 12:07:02 UTC 2018
PRIMARY
EVMPD
SUB05234MIG
Created by admin on Tue Mar 06 12:07:02 UTC 2018 , Edited by admin on Tue Mar 06 12:07:02 UTC 2018
PRIMARY
RXCUI
15978
Created by admin on Tue Mar 06 12:07:02 UTC 2018 , Edited by admin on Tue Mar 06 12:07:02 UTC 2018
PRIMARY RxNorm
MESH
C018802
Created by admin on Tue Mar 06 12:07:02 UTC 2018 , Edited by admin on Tue Mar 06 12:07:02 UTC 2018
PRIMARY
CAS
57-08-9
Created by admin on Tue Mar 06 12:07:02 UTC 2018 , Edited by admin on Tue Mar 06 12:07:02 UTC 2018
PRIMARY
MERCK INDEX
M1316
Created by admin on Tue Mar 06 12:07:02 UTC 2018 , Edited by admin on Tue Mar 06 12:07:02 UTC 2018
PRIMARY Merck Index
ECHA (EC/EINECS)
200-310-8
Created by admin on Tue Mar 06 12:07:02 UTC 2018 , Edited by admin on Tue Mar 06 12:07:02 UTC 2018
PRIMARY
NCI_THESAURUS
C80535
Created by admin on Tue Mar 06 12:07:02 UTC 2018 , Edited by admin on Tue Mar 06 12:07:02 UTC 2018
PRIMARY
INN
2246
Created by admin on Tue Mar 06 12:07:02 UTC 2018 , Edited by admin on Tue Mar 06 12:07:02 UTC 2018
PRIMARY