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Details

Stereochemistry ACHIRAL
Molecular Formula 2C8H14NO3.Ca
Molecular Weight 384.481
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ACEXAMATE CALCIUM

SMILES

[Ca++].CC(=O)NCCCCCC([O-])=O.CC(=O)NCCCCCC([O-])=O

InChI

InChIKey=SBWAKKRVPRVVTI-UHFFFAOYSA-L
InChI=1S/2C8H15NO3.Ca/c2*1-7(10)9-6-4-2-3-5-8(11)12;/h2*2-6H2,1H3,(H,9,10)(H,11,12);/q;;+2/p-2

HIDE SMILES / InChI

Molecular Formula Ca
Molecular Weight 40.078
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C8H14NO3
Molecular Weight 172.2017
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: The description was created based on several sources, including https://www.drugs.com/international/acexamic-acid.html | https://www.ncbi.nlm.nih.gov/pubmed/18353035 | https://www.ncbi.nlm.nih.gov/pubmed/6159453 | https://www.ncbi.nlm.nih.gov/pubmed/19470000

Acexamic acid (N-acetyl-amino-6-hexanoic acid) is a drug used as a cicatrization helper. Some studies show that the acexamic acid prevents the formation the connective inflamed tissue and enables its healing. The association from acexamic acid with zinc, zinc acexamate, has been used in the treatment of gastric and duodenal ulcer and in the prevention of gastric ulcer induced by nonsteroidal anti-inflammatory drugs.

Originator

Sources: Zeitschrift fuer Naturforschung (1947), 2b, 182-4

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Acemin ointment

Approved Use

Long-lasting non-healing wounds, skin and mucous burns, chronic traumatic osteomyelitis, closed and long-lasting incomplete fractures of bones, prevention of hyper-scarring, acceleration of the formation of a postoperative cosmetic scar, acceleration of engraftment of auto- and homotransplants.
Curative
Acemin ointment

Approved Use

Long-lasting non-healing wounds, skin and mucous burns, chronic traumatic osteomyelitis, closed and long-lasting incomplete fractures of bones, prevention of hyper-scarring, acceleration of the formation of a postoperative cosmetic scar, acceleration of engraftment of auto- and homotransplants.
PubMed

PubMed

TitleDatePubMed
Enhancement of albumin expression in bone tissues with healing rat fractures.
2003 May 15
Topical treatment of peritoneal catheter-related exit-site granuloma with acetamidohexanoic acid combined with gentamicin.
2006 Jul-Aug
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: http://www.lsgeotar.ru/atsexamovaya-kislota.html
Outer: 5% ointment is applied to the disinfected wound surface daily. The course of treatment is from 10 to 30 days.
Route of Administration: Topical
The mouse fibroblast cell line (NCTC Clone L 929) was maintained as stock culture in a minimum essential medium (MEM) supplemented with 10% calf serum and 200 i.u./ml G penicillin and 100 pg/d streptomycin. Cultures for growth studies were established by inoculating 7 X l0^4 cells in 2 ml medium in 35-mm plastic tissue culture dishes. They were maintained for 24 h to obtain a good attachment, then incubated in 5% calf serum medium supplemented or not with the drugs tested. Acexamic acid increased the growth rate of L 929 when used at a concentration of 0.001%
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:10:54 UTC 2023
Edited
by admin
on Fri Dec 15 15:10:54 UTC 2023
Record UNII
3DHV2K82D1
Record Status Validated (UNII)
Record Version
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Name Type Language
ACEXAMATE CALCIUM
WHO-DD  
Common Name English
Acexamate calcium [WHO-DD]
Common Name English
HEXANOIC ACID, 6-(ACETYLAMINO)-, CALCIUM SALT (2:1)
Common Name English
CALCIUM 6-ACETAMIDOHEXANOATE
Systematic Name English
CALCIUM ACEXAMATE
Common Name English
NSC-168217
Code English
ACEXAMIC ACID, CALCIUM SALT
Common Name English
Code System Code Type Description
EVMPD
SUB00279MIG
Created by admin on Fri Dec 15 15:10:54 UTC 2023 , Edited by admin on Fri Dec 15 15:10:54 UTC 2023
PRIMARY
ECHA (EC/EINECS)
253-010-4
Created by admin on Fri Dec 15 15:10:54 UTC 2023 , Edited by admin on Fri Dec 15 15:10:54 UTC 2023
PRIMARY
NSC
168217
Created by admin on Fri Dec 15 15:10:54 UTC 2023 , Edited by admin on Fri Dec 15 15:10:54 UTC 2023
PRIMARY
PUBCHEM
9886373
Created by admin on Fri Dec 15 15:10:54 UTC 2023 , Edited by admin on Fri Dec 15 15:10:54 UTC 2023
PRIMARY
CAS
36392-66-2
Created by admin on Fri Dec 15 15:10:54 UTC 2023 , Edited by admin on Fri Dec 15 15:10:54 UTC 2023
PRIMARY
SMS_ID
100000078830
Created by admin on Fri Dec 15 15:10:54 UTC 2023 , Edited by admin on Fri Dec 15 15:10:54 UTC 2023
PRIMARY
FDA UNII
3DHV2K82D1
Created by admin on Fri Dec 15 15:10:54 UTC 2023 , Edited by admin on Fri Dec 15 15:10:54 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY