ZATOSETRON MALEATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H25ClN2O2.C4H4O4
Molecular Weight	464.939
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)\C=C/C(O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)NC(=O)C3=CC(Cl)=CC4=C3OC(C)(C)C4

InChI

InChIKey=HAFQATMFFHYNPN-QRPZPOMXSA-N

InChI=1S/C19H25ClN2O2.C4H4O4/c1-19(2)10-11-6-12(20)7-16(17(11)24-19)18(23)21-13-8-14-4-5-15(9-13)22(14)3;5-3(6)1-2-4(7)8/h6-7,13-15H,4-5,8-10H2,1-3H3,(H,21,23);1-2H,(H,5,6)(H,7,8)/b;2-1-/t13-,14+,15-;

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1732548 | https://www.ncbi.nlm.nih.gov/pubmed/7984290 | https://www.ncbi.nlm.nih.gov/pubmed/7517409 | https://www.ncbi.nlm.nih.gov/pubmed/10211913

Zatosetron is a potent, selective, orally effective 5HT3 receptor antagonist. It has been studied in the treatment of emesis, migraine and anxiety.

CNS Activity

Originator

Approval Year

Patents

Name

Type

Language

ZATOSETRON MALEATE

Official Name

English

ZATOSETRON MALEATE [USAN]

Common Name

English

7-BENZOFURANCARBOXAMIDE, 5-CHLORO-2,3-DIHYDRO-2,2-DIMETHYL-N-(8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL)-, ENDO-, (Z)-2-BUTENEDIOATE (1:1)

Common Name

English

7-BENZOFURANCARBOXAMIDE, 5-CHLORO-2,3-DIHYDRO-2,2-DIMETHYL-N-((3-ENDO)-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL)-, (2Z)-2-BUTENEDIOATE (1:1)

Common Name

English

LY-277359 MALEATE

Code

English

LY277359 MALEATE

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C94726