U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C21H36NO
Molecular Weight 318.5174
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 1

SHOW SMILES / InChI
Structure of TRIDIHEXETHYL

SMILES

CC[N+](CC)(CC)CCC(c1ccccc1)(C2CCCCC2)O

InChI

InChIKey=NPRHVSBSZMAEIN-UHFFFAOYSA-N
InChI=1S/C21H36NO/c1-4-22(5-2,6-3)18-17-21(23,19-13-9-7-10-14-19)20-15-11-8-12-16-20/h7,9-10,13-14,20,23H,4-6,8,11-12,15-18H2,1-3H3/q+1

HIDE SMILES / InChI
Tridihexethyl is a synthetic anticholinergic agent which was marketed under the brand name Pathilon as an adjunct in the treatment of peptic ulcer disease. However, it is no longer available in the US market. Tridihexethyl may block all three types of muscarinic receptors including M-1 receptors in the CNS and ganglia, M-2 receptors in the heart, and M-3 receptors. The muscarinic acetylcholine receptors mediate various cellular responses including inhibition of adenylate cyclase, the breakdown of phosphoinositides, and modulation of potassium channels through the action of G proteins. Tridihexethyl inhibits vagally mediated reflexes by antagonizing the action of acetylcholine. This, in turn, reduces the secretion of gastric acids in the stomach. Tridihexethyl was also examined for effect on patients with acquired nystagmus where four out of six patients showed improvement, but due to the profile usage of Tridihexethyl to treat nystagmus was limited.

Approval Year

PubMed

PubMed

TitleDatePubMed
Influence of the anticholineric drug pathilon on the reproductive cycle of the female rat.
1958 Apr
Results of treatment of gastric and gastroduodenal ulcer with trepidon-pathilon.
1962
Transient visual anomalies associated with drug treatment for spastic colon.
1986 Aug
Effect of anticholinergic agents upon acquired nystagmus: a double-blind study of trihexyphenidyl and tridihexethyl chloride.
1991 Nov
Patents

Patents

Sample Use Guides

Unknown
Route of Administration: Parenteral
In Vitro Use Guide
Unknown
Name Type Language
TRIDIHEXETHYL
VANDF   WHO-DD  
Common Name English
(3-CYCLOHEXYL-3-HYDROXY-3-PHENYLPROPYL)TRIETHYLAMMONIUM
Systematic Name English
TRIDIHEXETHYL CATION
Common Name English
TRIDIHEXETHYL ION
Common Name English
BENZENEPROPANAMINIUM, .GAMMA.-CYCLOHEXYL-N,N,N-TRIETHYL-.GAMMA.-HYDROXY-
Systematic Name English
TRIDIHEXETHYL [VANDF]
Common Name English
TRIDIHEXETHYL [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29704
Created by admin on Sat Jun 26 07:12:41 UTC 2021 , Edited by admin on Sat Jun 26 07:12:41 UTC 2021
WHO-ATC A03AB08
Created by admin on Sat Jun 26 07:12:41 UTC 2021 , Edited by admin on Sat Jun 26 07:12:41 UTC 2021
WHO-VATC QA03AB08
Created by admin on Sat Jun 26 07:12:41 UTC 2021 , Edited by admin on Sat Jun 26 07:12:41 UTC 2021
Code System Code Type Description
DRUG BANK
DB00505
Created by admin on Sat Jun 26 07:12:41 UTC 2021 , Edited by admin on Sat Jun 26 07:12:41 UTC 2021
PRIMARY
NCI_THESAURUS
C78079
Created by admin on Sat Jun 26 07:12:41 UTC 2021 , Edited by admin on Sat Jun 26 07:12:41 UTC 2021
PRIMARY
FDA UNII
7HE50A367X
Created by admin on Sat Jun 26 07:12:41 UTC 2021 , Edited by admin on Sat Jun 26 07:12:41 UTC 2021
PRIMARY
EPA CompTox
60-49-1
Created by admin on Sat Jun 26 07:12:41 UTC 2021 , Edited by admin on Sat Jun 26 07:12:41 UTC 2021
PRIMARY
PUBCHEM
20299
Created by admin on Sat Jun 26 07:12:41 UTC 2021 , Edited by admin on Sat Jun 26 07:12:41 UTC 2021
PRIMARY
CAS
60-49-1
Created by admin on Sat Jun 26 07:12:41 UTC 2021 , Edited by admin on Sat Jun 26 07:12:41 UTC 2021
PRIMARY
DRUG CENTRAL
2737
Created by admin on Sat Jun 26 07:12:41 UTC 2021 , Edited by admin on Sat Jun 26 07:12:41 UTC 2021
PRIMARY
MESH
C005386
Created by admin on Sat Jun 26 07:12:41 UTC 2021 , Edited by admin on Sat Jun 26 07:12:41 UTC 2021
PRIMARY
EVMPD
SUB04951MIG
Created by admin on Sat Jun 26 07:12:41 UTC 2021 , Edited by admin on Sat Jun 26 07:12:41 UTC 2021
PRIMARY
WIKIPEDIA
TRIDIHEXETHYL
Created by admin on Sat Jun 26 07:12:41 UTC 2021 , Edited by admin on Sat Jun 26 07:12:41 UTC 2021
PRIMARY
RXCUI
38617
Created by admin on Sat Jun 26 07:12:41 UTC 2021 , Edited by admin on Sat Jun 26 07:12:41 UTC 2021
PRIMARY RxNorm