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Details

Stereochemistry RACEMIC
Molecular Formula C21H36NO.I
Molecular Weight 445.4211
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRIDIHEXETHYL IODIDE

SMILES

[I-].CC[N+](CC)(CC)CCC(O)(C1CCCCC1)C2=CC=CC=C2

InChI

InChIKey=VFEDLMLHAGASHB-UHFFFAOYSA-M
InChI=1S/C21H36NO.HI/c1-4-22(5-2,6-3)18-17-21(23,19-13-9-7-10-14-19)20-15-11-8-12-16-20;/h7,9-10,13-14,20,23H,4-6,8,11-12,15-18H2,1-3H3;1H/q+1;/p-1

HIDE SMILES / InChI

Molecular Formula HI
Molecular Weight 127.9124
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C21H35NO
Molecular Weight 317.5087
Charge 0
Count
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Tridihexethyl is a synthetic anticholinergic agent which was marketed under the brand name Pathilon as an adjunct in the treatment of peptic ulcer disease. However, it is no longer available in the US market. Tridihexethyl may block all three types of muscarinic receptors including M-1 receptors in the CNS and ganglia, M-2 receptors in the heart, and M-3 receptors. The muscarinic acetylcholine receptors mediate various cellular responses including inhibition of adenylate cyclase, the breakdown of phosphoinositides, and modulation of potassium channels through the action of G proteins. Tridihexethyl inhibits vagally mediated reflexes by antagonizing the action of acetylcholine. This, in turn, reduces the secretion of gastric acids in the stomach. Tridihexethyl was also examined for effect on patients with acquired nystagmus where four out of six patients showed improvement, but due to the profile usage of Tridihexethyl to treat nystagmus was limited.

Approval Year

PubMed

PubMed

TitleDatePubMed
Influence of the anticholineric drug pathilon on the reproductive cycle of the female rat.
1958 Apr
Transient visual anomalies associated with drug treatment for spastic colon.
1986 Aug
Patents

Patents

Sample Use Guides

Unknown
Route of Administration: Parenteral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:03:32 UTC 2023
Edited
by admin
on Sat Dec 16 17:03:32 UTC 2023
Record UNII
7Y7FXO7GQP
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TRIDIHEXETHYL IODIDE
INN   MI   WHO-DD  
INN  
Official Name English
TRIDIHEXETHYL IODIDE [MI]
Common Name English
Tridihexethyl iodide [WHO-DD]
Common Name English
tridihexethyl iodide [INN]
Common Name English
PROPETHONIUM IODIDE
Common Name English
TRIDIHEXETHIDE
Common Name English
CLAVITON
Brand Name English
BENZENEPROPANAMINIUM, .GAMMA.-CYCLOHEXYL-N,N,N-TRIETHYL-.GAMMA.-HYDROXY-, IODIDE (1:1)
Systematic Name English
TRIDIHEXIDE
Common Name English
(3-CYCLOHEXYL-3-HYDROXY-3-PHENYLPROPYL)TRIETHYLAMMONIUM IODIDE
Systematic Name English
TRIHEXETHYL IODIDE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29704
Created by admin on Sat Dec 16 17:03:32 UTC 2023 , Edited by admin on Sat Dec 16 17:03:32 UTC 2023
Code System Code Type Description
MERCK INDEX
m11096
Created by admin on Sat Dec 16 17:03:32 UTC 2023 , Edited by admin on Sat Dec 16 17:03:32 UTC 2023
PRIMARY Merck Index
MESH
C005386
Created by admin on Sat Dec 16 17:03:32 UTC 2023 , Edited by admin on Sat Dec 16 17:03:32 UTC 2023
PRIMARY
FDA UNII
7Y7FXO7GQP
Created by admin on Sat Dec 16 17:03:32 UTC 2023 , Edited by admin on Sat Dec 16 17:03:32 UTC 2023
PRIMARY
EPA CompTox
DTXSID00875351
Created by admin on Sat Dec 16 17:03:32 UTC 2023 , Edited by admin on Sat Dec 16 17:03:32 UTC 2023
PRIMARY
ChEMBL
CHEMBL1201354
Created by admin on Sat Dec 16 17:03:32 UTC 2023 , Edited by admin on Sat Dec 16 17:03:32 UTC 2023
PRIMARY
CAS
125-99-5
Created by admin on Sat Dec 16 17:03:32 UTC 2023 , Edited by admin on Sat Dec 16 17:03:32 UTC 2023
PRIMARY
ECHA (EC/EINECS)
204-762-7
Created by admin on Sat Dec 16 17:03:32 UTC 2023 , Edited by admin on Sat Dec 16 17:03:32 UTC 2023
PRIMARY
PUBCHEM
31334
Created by admin on Sat Dec 16 17:03:32 UTC 2023 , Edited by admin on Sat Dec 16 17:03:32 UTC 2023
PRIMARY
SMS_ID
100000077740
Created by admin on Sat Dec 16 17:03:32 UTC 2023 , Edited by admin on Sat Dec 16 17:03:32 UTC 2023
PRIMARY
INN
551
Created by admin on Sat Dec 16 17:03:32 UTC 2023 , Edited by admin on Sat Dec 16 17:03:32 UTC 2023
PRIMARY
NCI_THESAURUS
C152741
Created by admin on Sat Dec 16 17:03:32 UTC 2023 , Edited by admin on Sat Dec 16 17:03:32 UTC 2023
PRIMARY
EVMPD
SUB11280MIG
Created by admin on Sat Dec 16 17:03:32 UTC 2023 , Edited by admin on Sat Dec 16 17:03:32 UTC 2023
PRIMARY
CHEBI
9704
Created by admin on Sat Dec 16 17:03:32 UTC 2023 , Edited by admin on Sat Dec 16 17:03:32 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY