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Details

Stereochemistry ACHIRAL
Molecular Formula C27H29NO
Molecular Weight 383.5253
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of JWH-182

SMILES

CCCCCN1C=C(C(=O)C2=C3C=CC=CC3=C(CCC)C=C2)C4=C1C=CC=C4

InChI

InChIKey=AKGUMDFQXWZHHS-UHFFFAOYSA-N
InChI=1S/C27H29NO/c1-3-5-10-18-28-19-25(23-14-8-9-15-26(23)28)27(29)24-17-16-20(11-4-2)21-12-6-7-13-22(21)24/h6-9,12-17,19H,3-5,10-11,18H2,1-2H3

HIDE SMILES / InChI

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P21554|||Q5UB37
Gene ID: 1268.0
Gene Symbol: CNR1
Target Organism: Homo sapiens (Human)
0.65 nM [Ki]
Target ID: P34972
Gene ID: 1269.0
Gene Symbol: CNR2
Target Organism: Homo sapiens (Human)
1.1 nM [Ki]
Name Type Language
JWH-182
Common Name English
(4-ETHYL-1-NAPHTHYL)-(1-PENTYLINDOL-3-YL)METHANONE
Systematic Name English
(1-PENTYL-1H-INDOL-3-YL)(4-PROPYL-1-NAPHTHALENYL)METHANONE
Systematic Name English
METHANONE, (1-PENTYL-1H-INDOL-3-YL)(4-PROPYL-1-NAPHTHALENYL)-
Systematic Name English
Classification Tree Code System Code
WIKIPEDIA Designer-drugs-JWH-182
Created by admin on Fri Dec 15 16:31:14 GMT 2023 , Edited by admin on Fri Dec 15 16:31:14 GMT 2023
Code System Code Type Description
FDA UNII
7H0XW15CON
Created by admin on Fri Dec 15 16:31:14 GMT 2023 , Edited by admin on Fri Dec 15 16:31:14 GMT 2023
PRIMARY
MANUFACTURER PRODUCT INFORMATION
JWH-182
Created by admin on Fri Dec 15 16:31:14 GMT 2023 , Edited by admin on Fri Dec 15 16:31:14 GMT 2023
PRIMARY JWH 182 is a potent synthetic cannabinoid (CB), activating the central CB1 receptor with a Ki value of 0.65 nM and the peripheral CB2 receptor with a Ki value of 1.1 nM.1 Its effects in cells and animals are unknown.
CAS
824960-02-3
Created by admin on Fri Dec 15 16:31:14 GMT 2023 , Edited by admin on Fri Dec 15 16:31:14 GMT 2023
PRIMARY
PUBCHEM
45268702
Created by admin on Fri Dec 15 16:31:14 GMT 2023 , Edited by admin on Fri Dec 15 16:31:14 GMT 2023
PRIMARY
WIKIPEDIA
JWH-182
Created by admin on Fri Dec 15 16:31:14 GMT 2023 , Edited by admin on Fri Dec 15 16:31:14 GMT 2023
PRIMARY JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors, with Ki values of 0.46nM at CB1 and 0.69nM at CB2. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher binding affinity (i.e. lower Ki) at CB1 than both its 4-methyl and 4-n-propyl homologues JWH-122 (CB1 Ki 0.69nM) and JWH-182 (CB1 Ki 0.65nM) respectively, and than the 4-methoxy compound JWH-081 (CB1 Ki 1.2nM).
EPA CompTox
DTXSID401337155
Created by admin on Fri Dec 15 16:31:14 GMT 2023 , Edited by admin on Fri Dec 15 16:31:14 GMT 2023
PRIMARY