JWH-182

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C27H29NO
Molecular Weight	383.5253
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of JWH-182

Structure Search

SMILES

CCCCCN1C=C(C(=O)C2=C3C=CC=CC3=C(CCC)C=C2)C4=C1C=CC=C4

InChI

InChIKey=AKGUMDFQXWZHHS-UHFFFAOYSA-N

InChI=1S/C27H29NO/c1-3-5-10-18-28-19-25(23-14-8-9-15-26(23)28)27(29)24-17-16-20(11-4-2)21-12-6-7-13-22(21)24/h6-9,12-17,19H,3-5,10-11,18H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C27H29NO
Molecular Weight	383.5253
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Cannabinoid receptor 1 33 Target ID: P21554\|\|\|Q5UB37 Gene ID: 1268.0 Gene Symbol: CNR1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/15582455	Agonist 2752		0.65 nM [Ki]
Cannabinoid receptor 2 28 Target ID: P34972 Gene ID: 1269.0 Gene Symbol: CNR2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/15582455	Agonist 2752		1.1 nM [Ki]

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:30:18 GMT 2025` Edited by `admin` on `Mon Mar 31 18:30:18 GMT 2025`
Record UNII	7H0XW15CON
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

JWH-182

Common Name

English

(1-PENTYL-1H-INDOL-3-YL)(4-PROPYL-1-NAPHTHALENYL)METHANONE

Preferred Name

English

(4-ETHYL-1-NAPHTHYL)-(1-PENTYLINDOL-3-YL)METHANONE

Systematic Name

English

METHANONE, (1-PENTYL-1H-INDOL-3-YL)(4-PROPYL-1-NAPHTHALENYL)-

Systematic Name

English

Classification Tree Code System Code

WIKIPEDIA

Designer-drugs-JWH-182

Created by admin on Mon Mar 31 18:30:18 GMT 2025 , Edited by admin on Mon Mar 31 18:30:18 GMT 2025

Code System Code Type Description

FDA UNII

7H0XW15CON

Created by admin on Mon Mar 31 18:30:18 GMT 2025 , Edited by admin on Mon Mar 31 18:30:18 GMT 2025

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MANUFACTURER PRODUCT INFORMATION

JWH-182

Created by admin on Mon Mar 31 18:30:18 GMT 2025 , Edited by admin on Mon Mar 31 18:30:18 GMT 2025

PRIMARY

JWH 182 is a potent synthetic cannabinoid (CB), activating the central CB1 receptor with a Ki value of 0.65 nM and the peripheral CB2 receptor with a Ki value of 1.1 nM.1 Its effects in cells and animals are unknown.

CAS

824960-02-3

Created by admin on Mon Mar 31 18:30:18 GMT 2025 , Edited by admin on Mon Mar 31 18:30:18 GMT 2025

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PUBCHEM

45268702

Created by admin on Mon Mar 31 18:30:18 GMT 2025 , Edited by admin on Mon Mar 31 18:30:18 GMT 2025

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WIKIPEDIA

JWH-182

Created by admin on Mon Mar 31 18:30:18 GMT 2025 , Edited by admin on Mon Mar 31 18:30:18 GMT 2025

PRIMARY

JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors, with Ki values of 0.46nM at CB1 and 0.69nM at CB2. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher binding affinity (i.e. lower Ki) at CB1 than both its 4-methyl and 4-n-propyl homologues JWH-122 (CB1 Ki 0.69nM) and JWH-182 (CB1 Ki 0.65nM) respectively, and than the 4-methoxy compound JWH-081 (CB1 Ki 1.2nM).

EPA CompTox

DTXSID401337155

Created by admin on Mon Mar 31 18:30:18 GMT 2025 , Edited by admin on Mon Mar 31 18:30:18 GMT 2025

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Related Record Type Details


					7H0XW15CON

JWH-182

ACTIVE MOIETY