Details
Stereochemistry | ACHIRAL |
Molecular Formula | C24H24N2O |
Molecular Weight | 356.4602 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCN1C=C(C(=O)NC2=C3C=CC=CC3=CC=C2)C4=C1C=CC=C4
InChI
InChIKey=GWCQNKRMTGVYIZ-UHFFFAOYSA-N
InChI=1S/C24H24N2O/c1-2-3-8-16-26-17-21(20-13-6-7-15-23(20)26)24(27)25-22-14-9-11-18-10-4-5-12-19(18)22/h4-7,9-15,17H,2-3,8,16H2,1H3,(H,25,27)
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL218 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21885167 |
10.0 nM [EC50] | ||
Target ID: CHEMBL253 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21885167 |
100.0 nM [Ki] |
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WIKIPEDIA |
Designer-drugs-NNE1
Created by
admin on Sat Dec 16 10:25:48 GMT 2023 , Edited by admin on Sat Dec 16 10:25:48 GMT 2023
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Code System | Code | Type | Description | ||
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1338925-11-3
Created by
admin on Sat Dec 16 10:25:48 GMT 2023 , Edited by admin on Sat Dec 16 10:25:48 GMT 2023
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PRIMARY | |||
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DTXSID50716467
Created by
admin on Sat Dec 16 10:25:48 GMT 2023 , Edited by admin on Sat Dec 16 10:25:48 GMT 2023
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54752945
Created by
admin on Sat Dec 16 10:25:48 GMT 2023 , Edited by admin on Sat Dec 16 10:25:48 GMT 2023
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NNE1
Created by
admin on Sat Dec 16 10:25:48 GMT 2023 , Edited by admin on Sat Dec 16 10:25:48 GMT 2023
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PRIMARY | NNE1 (also known as NNEI, MN-24 and AM-6527) is an indole-based synthetic cannabinoid, representing a molecular hybrid of APICA and JWH-018. It was invented by Abbott and has a CB1 receptor pEC50 of 8.9 (i.e. EC50 of approximately 1nM) with around 80x selectivity over the related CB2 receptor. It is suspected that metabolic hydrolysis of the amide group of NNE1 may release 1-naphthylamine, a known carcinogen, given the known metabolic liberation (and presence as an impurity) of amantadine in the related compound APINACA, and NNE1 was banned in New Zealand in 2012 as a temporary class drug to stop it being used as an ingredient in then-legal synthetic cannabis products.(3) NNE1 was subsequently found to be responsible for the death of a man in Japan in 2014. | ||
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7FVT9P642K
Created by
admin on Sat Dec 16 10:25:48 GMT 2023 , Edited by admin on Sat Dec 16 10:25:48 GMT 2023
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PRIMARY | |||
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MN-24
Created by
admin on Sat Dec 16 10:25:48 GMT 2023 , Edited by admin on Sat Dec 16 10:25:48 GMT 2023
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PRIMARY |
ACTIVE MOIETY