Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C16H15F3N4 |
| Molecular Weight | 320.3123 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
N[C@@H]1C[C@@H](CN(C1)C2=C3C=CC=NC3=C(C=C2)C#N)C(F)(F)F
InChI
InChIKey=BJXYHBKEQFQVES-NWDGAFQWSA-N
InChI=1S/C16H15F3N4/c17-16(18,19)11-6-12(21)9-23(8-11)14-4-3-10(7-20)15-13(14)2-1-5-22-15/h1-5,11-12H,6,8-9,21H2/t11-,12+/m0/s1
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
0.834 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
2.64 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
11.4 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
9 mg single, oral dose: 9 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
22.5 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
25 mg single, oral dose: 25 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
50.6 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
50 mg single, oral dose: 50 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
121 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
230 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
20 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
25 mg single, oral dose: 25 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
13.2 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
9 mg 1 times / day multiple, oral dose: 9 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
29.8 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
25 mg 1 times / day multiple, oral dose: 25 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
325 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
200 mg 1 times / day multiple, oral dose: 200 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
37 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
25 mg 2 times / day multiple, oral dose: 25 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
70 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
50 mg 2 times / day multiple, oral dose: 50 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
7.02 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
18.6 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
75 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
9 mg single, oral dose: 9 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
163 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
25 mg single, oral dose: 25 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
317 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
50 mg single, oral dose: 50 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
744 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
1580 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
216 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
25 mg single, oral dose: 25 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
78.2 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
9 mg 1 times / day multiple, oral dose: 9 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
178 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
25 mg 1 times / day multiple, oral dose: 25 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
1392 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
200 mg 1 times / day multiple, oral dose: 200 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
190 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
25 mg 2 times / day multiple, oral dose: 25 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
368 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
50 mg 2 times / day multiple, oral dose: 50 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
6.81 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
6.83 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
7.11 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
9 mg single, oral dose: 9 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
7.87 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
25 mg single, oral dose: 25 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
7.45 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
50 mg single, oral dose: 50 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
10.1 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
10.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
8.42 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
25 mg single, oral dose: 25 mg route of administration: Oral experiment type: SINGLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
7.46 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
9 mg 1 times / day multiple, oral dose: 9 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
8.14 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
25 mg 1 times / day multiple, oral dose: 25 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
7.69 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
200 mg 1 times / day multiple, oral dose: 200 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
8.27 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
25 mg 2 times / day multiple, oral dose: 25 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
8.74 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/ |
50 mg 2 times / day multiple, oral dose: 50 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
ENPATORAN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Official Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
11880
Created by
admin on Wed Apr 02 04:33:06 GMT 2025 , Edited by admin on Wed Apr 02 04:33:06 GMT 2025
|
PRIMARY | |||
|
JK-264
Created by
admin on Wed Apr 02 04:33:06 GMT 2025 , Edited by admin on Wed Apr 02 04:33:06 GMT 2025
|
PRIMARY | |||
|
7CZ390V26X
Created by
admin on Wed Apr 02 04:33:06 GMT 2025 , Edited by admin on Wed Apr 02 04:33:06 GMT 2025
|
PRIMARY | |||
|
129240620
Created by
admin on Wed Apr 02 04:33:06 GMT 2025 , Edited by admin on Wed Apr 02 04:33:06 GMT 2025
|
PRIMARY | |||
|
C177069
Created by
admin on Wed Apr 02 04:33:06 GMT 2025 , Edited by admin on Wed Apr 02 04:33:06 GMT 2025
|
PRIMARY | |||
|
300000023092
Created by
admin on Wed Apr 02 04:33:06 GMT 2025 , Edited by admin on Wed Apr 02 04:33:06 GMT 2025
|
PRIMARY | |||
|
NCT03676322
Created by
admin on Wed Apr 02 04:33:06 GMT 2025 , Edited by admin on Wed Apr 02 04:33:06 GMT 2025
|
PRIMARY | |||
|
2101938-42-3
Created by
admin on Wed Apr 02 04:33:06 GMT 2025 , Edited by admin on Wed Apr 02 04:33:06 GMT 2025
|
PRIMARY |
ACTIVE MOIETY
