ENPATORAN

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H15F3N4
Molecular Weight	320.3123
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N[C@@H]1C[C@@H](CN(C1)C2=C3C=CC=NC3=C(C=C2)C#N)C(F)(F)F

InChI

InChIKey=BJXYHBKEQFQVES-NWDGAFQWSA-N

InChI=1S/C16H15F3N4/c17-16(18,19)11-6-12(21)9-23(8-11)14-4-3-10(7-20)15-13(14)2-1-5-22-15/h1-5,11-12H,6,8-9,21H2/t11-,12+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C16H15F3N4
Molecular Weight	320.3123
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

C_max

Value	Dose	Analyte	Population
0.834 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
2.64 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
11.4 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	9 mg single, oral dose: 9 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
22.5 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	25 mg single, oral dose: 25 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
50.6 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	50 mg single, oral dose: 50 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
121 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
230 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
20 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	25 mg single, oral dose: 25 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED
13.2 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	9 mg 1 times / day multiple, oral dose: 9 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
29.8 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	25 mg 1 times / day multiple, oral dose: 25 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
325 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	200 mg 1 times / day multiple, oral dose: 200 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
37 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	25 mg 2 times / day multiple, oral dose: 25 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
70 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	50 mg 2 times / day multiple, oral dose: 50 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

AUC

Value	Dose	Analyte	Population
7.02 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
18.6 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
75 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	9 mg single, oral dose: 9 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
163 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	25 mg single, oral dose: 25 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
317 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	50 mg single, oral dose: 50 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
744 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
1580 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
216 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	25 mg single, oral dose: 25 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED
78.2 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	9 mg 1 times / day multiple, oral dose: 9 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
178 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	25 mg 1 times / day multiple, oral dose: 25 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
1392 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	200 mg 1 times / day multiple, oral dose: 200 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
190 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	25 mg 2 times / day multiple, oral dose: 25 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
368 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	50 mg 2 times / day multiple, oral dose: 50 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

T_1/2

Value	Dose	Analyte	Population
6.81 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
6.83 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
7.11 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	9 mg single, oral dose: 9 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
7.87 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	25 mg single, oral dose: 25 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
7.45 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	50 mg single, oral dose: 50 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
10.1 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
10.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
8.42 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	25 mg single, oral dose: 25 mg route of administration: Oral experiment type: SINGLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED
7.46 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	9 mg 1 times / day multiple, oral dose: 9 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
8.14 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	25 mg 1 times / day multiple, oral dose: 25 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
7.69 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	200 mg 1 times / day multiple, oral dose: 200 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
8.27 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	25 mg 2 times / day multiple, oral dose: 25 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
8.74 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/34414672/	50 mg 2 times / day multiple, oral dose: 50 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ENPATORAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

Substance Class	Chemical Created by `admin` on `Wed Apr 02 04:33:06 GMT 2025` Edited by `admin` on `Wed Apr 02 04:33:06 GMT 2025`
Record UNII	7CZ390V26X
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

M-5049

Preferred Name

English

ENPATORAN

Official Name

English

ENPATORAN [USAN]

Common Name

English

5-((3R,5S)-3-AMINO-5-TRIFLUOROMETHYLPIPERIDIN-1-YL)QUINOLINE-8-CARBONITRILE

Systematic Name

English

enpatoran [INN]

Common Name

English

M5049

Code

English

Enpatoran [WHO-DD]

Common Name

English

8-QUINOLINECARBONITRILE, 5-((3R,5S)-3-AMINO-5-(TRIFLUOROMETHYL)-1-PIPERIDINYL)-

Systematic Name

English

Code System Code Type Description

INN

11880