U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C28H28ClF2N3O
Molecular Weight 495.991
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CLOPIMOZIDE

SMILES

FC1=CC=C(C=C1)C(CCCN2CCC(CC2)N3C(=O)NC4=C3C=CC(Cl)=C4)C5=CC=C(F)C=C5

InChI

InChIKey=JCZYXTVBWHAWLL-UHFFFAOYSA-N
InChI=1S/C28H28ClF2N3O/c29-21-7-12-27-26(18-21)32-28(35)34(27)24-13-16-33(17-14-24)15-1-2-25(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24-25H,1-2,13-17H2,(H,32,35)

HIDE SMILES / InChI
Clopimozide is a typical antipsychotic drug, developed by Janssen Pharmaceutica. Clopimozide belongs to diphenylbutylpiperidine class of neuroleptics, and possess an extremely long duration of action. The drug acts by binding to dopamine receptors and by inhibition of calcium channels. In a clinical trial, clopimozide exhibited a marked effect on schizophrenic target symptoms, with an absence of sedation and a low degree of extrapyramidal side-effects. Despite positive results, the drug was never marketed.

Approval Year

PubMed

PubMed

TitleDatePubMed
Percutaneous stenting of the left main with drug eluting stents for in-stent restenosis: immediate- and long-term results.
2006 Jun
Name Type Language
CLOPIMOZIDE
INN   USAN  
USAN   INN  
Official Name English
R 29,764
Code English
R-29764
Code English
2H-BENZIMIDAZOL-2-ONE, 1-(1-(4,4-BIS(4-FLUOROPHENYL)BUTYL)-4-PIPERIDINYL)-5-CHLORO-1,3-DIHYDRO-
Systematic Name English
CLOPIMOZIDE [USAN]
Common Name English
clopimozide [INN]
Common Name English
NSC-335305
Code English
1-(1-(4,4-BIS(P-FLUOROPHENYL)BUTYL)-4-PIPERIDYL)-5-CHLORO-2-BENZIMIDAZOLINONE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C66883
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
Code System Code Type Description
CAS
53179-12-7
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
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WIKIPEDIA
Clopimozide
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
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PUBCHEM
65449
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
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SMS_ID
100000083998
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
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EVMPD
SUB06740MIG
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
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INN
3783
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
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ChEMBL
CHEMBL2104161
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
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FDA UNII
7C6TA32SD2
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
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NSC
335305
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
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NCI_THESAURUS
C77571
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
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EPA CompTox
DTXSID60201238
Created by admin on Fri Dec 15 16:12:40 GMT 2023 , Edited by admin on Fri Dec 15 16:12:40 GMT 2023
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