CLOPIMOZIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C28H28ClF2N3O
Molecular Weight	495.991
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC=C(C=C1)C(CCCN2CCC(CC2)N3C(=O)NC4=C3C=CC(Cl)=C4)C5=CC=C(F)C=C5

InChI

InChIKey=JCZYXTVBWHAWLL-UHFFFAOYSA-N

InChI=1S/C28H28ClF2N3O/c29-21-7-12-27-26(18-21)32-28(35)34(27)24-13-16-33(17-14-24)15-1-2-25(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24-25H,1-2,13-17H2,(H,32,35)

HIDE SMILES / InChI

Molecular Formula	C28H28ClF2N3O
Molecular Weight	495.991
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1242360 | https://www.ncbi.nlm.nih.gov/pubmed/25071 | https://www.ncbi.nlm.nih.gov/pubmed/6136040 |

Clopimozide is a typical antipsychotic drug, developed by Janssen Pharmaceutica. Clopimozide belongs to diphenylbutylpiperidine class of neuroleptics, and possess an extremely long duration of action. The drug acts by binding to dopamine receptors and by inhibition of calcium channels. In a clinical trial, clopimozide exhibited a marked effect on schizophrenic target symptoms, with an absence of sedation and a low degree of extrapyramidal side-effects. Despite positive results, the drug was never marketed.

Approval Year

PubMed

Title	Date	PubMed

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:12:40 UTC 2023` Edited by `admin` on `Fri Dec 15 16:12:40 UTC 2023`
Record UNII	7C6TA32SD2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CLOPIMOZIDE

Official Name

English

R 29,764

Code

English

R-29764

Code

English

2H-BENZIMIDAZOL-2-ONE, 1-(1-(4,4-BIS(4-FLUOROPHENYL)BUTYL)-4-PIPERIDINYL)-5-CHLORO-1,3-DIHYDRO-

Systematic Name

English

CLOPIMOZIDE [USAN]

Common Name

English

clopimozide [INN]

Common Name

English

NSC-335305

Code

English

1-(1-(4,4-BIS(P-FLUOROPHENYL)BUTYL)-4-PIPERIDYL)-5-CHLORO-2-BENZIMIDAZOLINONE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66883