Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H20Cl4N2.2Cl |
| Molecular Weight | 429.04 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Cl-].[Cl-].C[N+](C)(C)CC[N+]1(C)CC2=C(C1)C(Cl)=C(Cl)C(Cl)=C2Cl
InChI
InChIKey=DXXUGBPKQDTBQW-UHFFFAOYSA-L
InChI=1S/C14H20Cl4N2.2ClH/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15;;/h5-8H2,1-4H3;2*1H/q+2;;/p-2
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Understanding channel blocking in the nicotinic acetylcholine receptor. | 2001 |
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| Modulation of neuronal nicotinic acetylcholine receptors by halothane in rat cortical neurons. | 2001 Apr |
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| Reversal of acute effects of high dose morphine on lymphocyte activity by chlorisondamine. | 2001 Apr 1 |
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| Dietary soy exerts an antihypertensive effect in spontaneously hypertensive female rats. | 2001 Aug |
|
| Nicotine prevents striatal dopamine loss produced by 6-hydroxydopamine lesion in the substantia nigra. | 2001 Jan 12 |
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| Pharmacological dissection of vascular effects caused by activation of protease-activated receptors 1 and 2 in anesthetized rats. | 2001 Jun |
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| Evidence that extrapancreatic GLUT2-dependent glucose sensors control glucagon secretion. | 2001 Jun |
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| Depletion of brown fat norepinephrine content by acute cold exposure and adrenoceptor blockade. | 2001 Mar |
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| Modulation of the leptin-induced white adipose tissue lipolysis by nitric oxide. | 2001 Nov |
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| Effects of antihypertensive drugs on ultrasound production and cardiovascular responses in 15-day-old rats. | 2002 Apr 1 |
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| Central urocortin activation of sympathetic-regulated energy metabolism in Wistar rats. | 2002 Mar 15 |
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| Heteromeric nicotinic inhibition by isoflurane does not mediate MAC or loss of righting reflex. | 2002 Oct |
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| Subclinical doses of the nerve gas sarin impair T cell responses through the autonomic nervous system. | 2002 Oct 15 |
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| Effect of intravenous angiotensin II infusion on responses to hypothalamic PVN injection of bicuculline. | 2003 Dec |
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| The role of ionotropic receptors of glutaminic acid in cardiovascular system. A. The influence of ionotropic receptor NMDA agonist - 1R,3R-ACPD and antagonist - DL-AP7 on the systemic pressure in rats. | 2003 Jun |
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| An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice. | 2003 Sep |
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| Supraspinal and systemic administration of the nicotinic-cholinergic agonist (+/-)-epibatidine has inhibitory effects on C-fiber reflexes in the rat. | 2004 Dec 15 |
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| Cardiovascular effects of nicotine, chlorisondamine, and mecamylamine in the pigeon. | 2004 Jan |
|
| Central but not the peripheral action of cholinergic compounds suppresses the immune system. | 2004 Mar |
|
| Salsolinol, an antagonist of prolactoliberine, induces an increase in plasma catecholamine levels in the rat. | 2004 Sep 30 |
|
| Vasodilatation of the hindquarters induced by antagonism of GABA(A) receptors in the freely moving rat. | 2005 Feb |
|
| Evaluation in rats and primates of [11C]-mecamylamine, a potential nicotinic acetylcholine receptor radioligand for positron emission tomography. | 2005 May |
|
| Effect of anabasine on catecholamine secretion from the perfused rat adrenal medulla. | 2007 Dec |
|
| Long- and short-term changes in the neuroimmune-endocrine parameters following inhalation exposures of F344 rats to low-dose sarin. | 2007 May |
|
| The effect of the cholinergic anti-inflammatory pathway on experimental colitis. | 2007 Nov |
|
| Nicotine-induced phosphorylation of ERK in mouse primary cortical neurons: evidence for involvement of glutamatergic signaling and CaMKII. | 2007 Oct |
|
| What's new in Nicotine & Tobacco Research? | 2007 Sep |
|
| Effect of chronic IL-6 infusion on acute pressor responses to vasoconstrictors in mice. | 2007 Sep |
|
| Peripheral and central routes of administration of quaternary ammonium compound IEM-1460 are equally potent in reducing the severity of nicotine-induced seizures in mice. | 2008 Jul |
Sample Use Guides
In cultured dissociated mesencephalic cells of the fetal rat, chlorisondamine inhibited [3H]-dopamine release evoked by N-methyl-D-aspartate (10^-4 M), but only at high concentrations (IC50 approx. 600 microM). A high concentration of chlorisondamine (10^-3 M) had no effect on responses to quisqualate (10^-5 M) and only slightly reduced responses to kainate (10^-4 M). In adult rat hippocampal slices, chlorisondamine depressed NMDA receptor-mediated synaptically-evoked field potentials, but again only at high concentrations (10^-4-10^-3 M). Synaptic responses that were mediated by non-NMDA excitatory amino acid receptors were less affected.
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C66886
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6243
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69-27-2
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609
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C76788
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m3371
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100000081562
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7B58W7756G
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SUB06182MIG
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CHEMBL1398654
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DTXSID7046332
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ACTIVE MOIETY
SUBSTANCE RECORD
