PERADOXIME

Details

Stereochemistry	RACEMIC
Molecular Formula	C22H29N3O4
Molecular Weight	399.4834
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC(C=NOCC(O)CN2CCN(CC2)C3=CC=CC=C3OC)=CC=C1

InChI

InChIKey=QSOFMSXQETVQGE-HAHDFKILSA-N

InChI=1S/C22H29N3O4/c1-27-20-7-5-6-18(14-20)15-23-29-17-19(26)16-24-10-12-25(13-11-24)21-8-3-4-9-22(21)28-2/h3-9,14-15,19,26H,10-13,16-17H2,1-2H3/b23-15-

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7333331 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 951, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Peradoxime is an antihypertensive agent. In normal animals, 37-48% of the radioactivity from an oral dose of labeled peradoxime or parenteral dose was excreted in the urine, and 48-50% in the feces. Biliary and urinary metabolites of peradoxime were principally found as conjugates with glucuronic acid.

Approval Year

PubMed

Title	Date	PubMed
Enterohepatic circulation in rat and dog of 14C-0-[3-(4-less than 2-methoxyphenyl greater than-1-piperazinyl)-2-hydroxypropyl]-3-methoxy-benzaldoxim dihydrochloride and it's demethylated metabolite.	1981	7333331

Sample Use Guides

In Vivo Use Guide

Single dose - 2 mg/kg of body weight

Route of Administration: Oral

Name

Type

Language

PERADOXIME

Official Name

English

peradoxime [INN]

Common Name

English

M-ANISALDEHYDE O-(2-HYDROXY-3-(4-(O-METHOXYPHENYL)-1-PIPERAZINYL)PROPYL) OXIME

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C241