CLORANOLOL HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C13H19Cl2NO2.ClH
Molecular Weight	328.662
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC(C)(C)NCC(O)COC1=CC(Cl)=CC=C1Cl

InChI

InChIKey=GSMITOPOWVFGOM-UHFFFAOYSA-N

InChI=1S/C13H19Cl2NO2.ClH/c1-13(2,3)16-7-10(17)8-18-12-6-9(14)4-5-11(12)15;/h4-6,10,16-17H,7-8H2,1-3H3;1H

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2868999 | https://www.ncbi.nlm.nih.gov/pubmed/1685755 | Tardos, L., Szekeres, L., Papp, Gy,J. (2013) Pharmacological Control of Heart and Circulation, page 253, retrieved from: https://books.google.ru/books?id=w14hBQAAQBAJ | https://www.drugfuture.com/chemdata/Cloranolol.html

Cloranolol is a specific beta-adrenergic antagonist. It is used as an antiarrhythmic agent. Its antiarrhythmic effectiveness stronger than propranol and equal or surpass the effectivity of pindolol. It has a negligible cardiodepressant activity as compared to other beta-adrenergic antagonists. Cloranolol has mainly cardiorespiratory side effects judging from the beta-blocker characteristics

Approval Year

PubMed

Title	Date	PubMed
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.	2010-12	21818443
Pharmacology of GYKI-41 099 (chlorpropanol, Tobanum) a new potent beta-adrenergic antagonist.	1980-12	6111982

Sample Use Guides

In Vivo Use Guide

Single dose - 10 mg

Route of Administration: Oral

Name

Type

Language

CLORANOLOL HYDROCHLORIDE

Common Name

English

GYKI-41099

Preferred Name

English

DICHLOROPHENOXY)-3-TERT-BUTYLAMINO-2-PROPANOL HYDROCHLORIDE

Common Name

English

Cloranolol hydrochloride [WHO-DD]

Common Name

English

CLORANOLOL HYDROCHLORIDE [MI]

Common Name

English

(±)-DICHLOROPHENOXY)-3-TERT-BUTYLAMINO-2-PROPANOL HYDROCHLORIDE

Common Name

English

CHLORPROPANOL HYDROCHLORIDE

Common Name

English

Code System Code Type Description

ECHA (EC/EINECS)

259-044-6