U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C20H28I3N3O13
Molecular Weight 899.162
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IOGLUCOMIDE

SMILES

CNC(=O)C1=C(I)C(NC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)=C(I)C(NC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)=C1I

InChI

InChIKey=ASFIRRNYUOVVLY-JVOWFEOISA-N
InChI=1S/C20H28I3N3O13/c1-24-18(37)6-7(21)10(25-19(38)16(35)14(33)12(31)4(29)2-27)9(23)11(8(6)22)26-20(39)17(36)15(34)13(32)5(30)3-28/h4-5,12-17,27-36H,2-3H2,1H3,(H,24,37)(H,25,38)(H,26,39)/t4-,5-,12-,13-,14+,15+,16-,17-/m1/s1

HIDE SMILES / InChI
Ioglucomide is triiodoanilide derivative patented by Mallinckrodt, Inc. as nonionic x-ray contrast media for myelography. In preclinical studies the efficacy of ioglucomide and metrizamide were comparable. However, acute toxicity after intravenous injection or installation into cerebrospinal fluid was significantly less for ioglucomide. Also, in contrast to metrizamide, ioglucomide produced no evidence of any type of convulsive activity after subarachnoid administration.

Approval Year

PubMed

PubMed

TitleDatePubMed
Ioglucomide: a new nonionic myelographic agent. Preclinical studies.
1981 Sep
Patents
Name Type Language
IOGLUCOMIDE
INN   USAN  
USAN   INN  
Official Name English
IOGLUCOMIDE [USAN]
Common Name English
N,N'-(2,4,6-TRIIODO-5-(METHYLCARBAMOYL)-M-PHENYLENE)BIS(D-GLUCONAMIDE)
Common Name English
ioglucomide [INN]
Common Name English
MP-8000
Code English
D-GLUCONAMIDE, N,N'-(2,4,6-TRIIODO-5-((METHYLAMINO)CARBONYL)-1,3-PHENYLENE)BIS-
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C28500
Created by admin on Fri Dec 15 16:54:46 GMT 2023 , Edited by admin on Fri Dec 15 16:54:46 GMT 2023
Code System Code Type Description
CAS
63941-74-2
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EPA CompTox
DTXSID101024309
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INN
4643
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EVMPD
SUB08225MIG
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FDA UNII
771V8M13LT
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ChEMBL
CHEMBL2104826
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SMS_ID
100000083655
Created by admin on Fri Dec 15 16:54:46 GMT 2023 , Edited by admin on Fri Dec 15 16:54:46 GMT 2023
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NCI_THESAURUS
C83825
Created by admin on Fri Dec 15 16:54:46 GMT 2023 , Edited by admin on Fri Dec 15 16:54:46 GMT 2023
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MESH
C031376
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PUBCHEM
71964
Created by admin on Fri Dec 15 16:54:46 GMT 2023 , Edited by admin on Fri Dec 15 16:54:46 GMT 2023
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