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Details

Stereochemistry RACEMIC
Molecular Formula C8H11NO4S2
Molecular Weight 249.307
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ERDOSTEINE

SMILES

OC(=O)CSCC(=O)NC1CCSC1=O

InChI

InChIKey=QGFORSXNKQLDNO-UHFFFAOYSA-N
InChI=1S/C8H11NO4S2/c10-6(3-14-4-7(11)12)9-5-1-2-15-8(5)13/h5H,1-4H2,(H,9,10)(H,11,12)

HIDE SMILES / InChI

Description

Erdosteine is an antioxidant compound developed by Edmond Pharma and approved in Europe for the treatment of chronic bronchitis and COPD. Erdosteine has two thiol groups and is believed to act as a free radicals scavenger (through the formation of the active metabolite I, N-thiodiglycolylhomocysteine). Also the drug effect may be due to the inhibition of the activity of elastase enzyme and its interaction with mucosa. The drug got Orphan Drug designation by FDA for the treatment of bronchiectasis.

Originator

Approval Year

PubMed

PubMed

TitleDatePubMed
Pharmacology and clinical efficacy of erdosteine in chronic obstructive pulmonary disease.
2007 Dec
Raft of results energizes researchers.
2009 Sep-Oct
Free radical scavenging activity of erdosteine metabolite I investigated by electron paramagnetic resonance spectroscopy.
2010
Ambroxol - Resurgence of an old molecule as an anti-inflammatory agent in chronic obstructive airway diseases.
2010 Apr
Beneficial effect of erdosteine on methotrexate-induced testicular toxicity in mice.
2010 Aug
Effects of sulphurous water on human neutrophil elastase release.
2010 Dec
Association between lung function and exacerbation frequency in patients with COPD.
2010 Dec 9
Modulation of cytokine and nitric oxide by mesenchymal stem cell transfer in lung injury/fibrosis.
2010 Feb 8
Exaggerated liver injury induced by renal ischemia reperfusion in diabetes: effect of exenatide.
2010 Jul-Sep
Effect of the mucolytic erdosteine on the success rate of PPI-based first-line triple therapy for Helicobacter pylori eradication: a prospective, double-blind, randomized, placebo-controlled study.
2010 Jun
Patents

Sample Use Guides

In Vivo Use Guide
1 capsule (300 mg) 2-3 times a day
Route of Administration: Oral
Name Type Language
ERDOSTEINE
INN   MART.   MI   WHO-DD  
INN  
Official Name English
ERDOSTEINE [MART.]
Common Name English
ERDOSTEINE [INN]
Common Name English
ERDOSTEINE [MI]
Common Name English
(+/-)-((((TETRAHYDRO-2-OXO-3-THIENYL)CARBAMOYL)METHYL)THIO)ACETIC ACID
Systematic Name English
MUCOTEC
Brand Name English
ERDOSTEINE [WHO-DD]
Common Name English
Classification Tree Code System Code
WHO-ATC R05CB15
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
WHO-VATC QR05CB15
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
Code System Code Type Description
NCI_THESAURUS
C61750
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
PRIMARY
MESH
C048498
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
PRIMARY
EVMPD
SUB06595MIG
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
PRIMARY
ChEMBL
CHEMBL1697744
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
PRIMARY
RXCUI
24305
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
PRIMARY RxNorm
EPA CompTox
84611-23-4
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
PRIMARY
PUBCHEM
65632
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
PRIMARY SWITZERF
MERCK INDEX
M4974
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
PRIMARY Merck Index
CAS
84611-23-4
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
PRIMARY
WIKIPEDIA
ERDOSTEINE
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
PRIMARY
INN
6032
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
PRIMARY