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Details

Stereochemistry RACEMIC
Molecular Formula C8H11NO4S2
Molecular Weight 249.307
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ERDOSTEINE

SMILES

OC(=O)CSCC(=O)NC1CCSC1=O

InChI

InChIKey=QGFORSXNKQLDNO-UHFFFAOYSA-N
InChI=1S/C8H11NO4S2/c10-6(3-14-4-7(11)12)9-5-1-2-15-8(5)13/h5H,1-4H2,(H,9,10)(H,11,12)

HIDE SMILES / InChI

Molecular Formula C8H11NO4S2
Molecular Weight 249.307
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Erdosteine is an antioxidant compound developed by Edmond Pharma and approved in Europe for the treatment of chronic bronchitis and COPD. Erdosteine has two thiol groups and is believed to act as a free radicals scavenger (through the formation of the active metabolite I, N-thiodiglycolylhomocysteine). Also the drug effect may be due to the inhibition of the activity of elastase enzyme and its interaction with mucosa. The drug got Orphan Drug designation by FDA for the treatment of bronchiectasis.

Originator

Approval Year

PubMed

PubMed

TitleDatePubMed
Pharmacology and clinical efficacy of erdosteine in chronic obstructive pulmonary disease.
2007 Dec
Antioxidant systems and oxidative stress in the testes.
2008 Oct-Dec
[Effects of erdosteine on inflammation and fibrosis in rats with pulmonary fibrosis induced by bleomycin].
2009
Erdosteine and ebselen as useful agents in intestinal ischemia/reperfusion injury.
2009 Aug
Erdosteine: its relevance in COPD treatment.
2009 Mar
The protective effect of erdosteine on vancomycin-induced pancreatic damage in rats.
2009 Nov
Raft of results energizes researchers.
2009 Sep-Oct
Free radical scavenging activity of erdosteine metabolite I investigated by electron paramagnetic resonance spectroscopy.
2010
Ambroxol - Resurgence of an old molecule as an anti-inflammatory agent in chronic obstructive airway diseases.
2010 Apr
Effectiveness of erdosteine, a second generation mucolytic agent, in children with acute rhinosinusitis: a randomized, placebo controlled, double-blinded clinical study.
2010 Apr
The therapeutic efficacy of erdosteine in the treatment of chronic obstructive bronchitis: a meta-analysis of individual patient data.
2010 Apr
Beneficial effect of erdosteine on methotrexate-induced testicular toxicity in mice.
2010 Aug
Effects of sulphurous water on human neutrophil elastase release.
2010 Dec
Association between lung function and exacerbation frequency in patients with COPD.
2010 Dec 9
Modulation of cytokine and nitric oxide by mesenchymal stem cell transfer in lung injury/fibrosis.
2010 Feb 8
Erdosteine in renal ischemia-reperfusion injury: an experimental study in pigs.
2010 Jan
Cardiotoxicity of anticancer drugs: the need for cardio-oncology and cardio-oncological prevention.
2010 Jan 6
Exaggerated liver injury induced by renal ischemia reperfusion in diabetes: effect of exenatide.
2010 Jul-Sep
Effect of the mucolytic erdosteine on the success rate of PPI-based first-line triple therapy for Helicobacter pylori eradication: a prospective, double-blind, randomized, placebo-controlled study.
2010 Jun
Combination antioxidant effect of α-tocoferol and erdosteine in ischemia-reperfusion injury in rat model.
2010 Sep
Patents

Sample Use Guides

In Vivo Use Guide
1 capsule (300 mg) 2-3 times a day
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Tue Mar 06 12:14:51 UTC 2018
Edited
by admin
on Tue Mar 06 12:14:51 UTC 2018
Record UNII
76J0853EKA
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ERDOSTEINE
INN   MART.   MI   WHO-DD  
INN  
Official Name English
ERDOSTEINE [MART.]
Common Name English
ERDOSTEINE [INN]
Common Name English
ERDOSTEINE [MI]
Common Name English
(+/-)-((((TETRAHYDRO-2-OXO-3-THIENYL)CARBAMOYL)METHYL)THIO)ACETIC ACID
Systematic Name English
MUCOTEC
Brand Name English
ERDOSTEINE [WHO-DD]
Common Name English
Classification Tree Code System Code
WHO-ATC R05CB15
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
WHO-VATC QR05CB15
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
Code System Code Type Description
NCI_THESAURUS
C61750
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
PRIMARY
MESH
C048498
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
PRIMARY
EVMPD
SUB06595MIG
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
PRIMARY
ChEMBL
CHEMBL1697744
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
PRIMARY
RXCUI
24305
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
PRIMARY RxNorm
EPA CompTox
84611-23-4
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
PRIMARY
PUBCHEM
65632
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
PRIMARY SWITZERF
MERCK INDEX
M4974
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
PRIMARY Merck Index
CAS
84611-23-4
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
PRIMARY
WIKIPEDIA
ERDOSTEINE
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
PRIMARY
INN
6032
Created by admin on Tue Mar 06 12:14:51 UTC 2018 , Edited by admin on Tue Mar 06 12:14:51 UTC 2018
PRIMARY
Related Record Type Details
ACTIVE MOIETY