| Stereochemistry | ABSOLUTE |
| Molecular Formula | C12H16O2 |
| Molecular Weight | 192.2542 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCC[C@@H]1OC(=O)C2=C1CCC=C2
InChI
InChIKey=ZPIKVDODKLJKIN-NSHDSACASA-N
InChI=1S/C12H16O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h5,7,11H,2-4,6,8H2,1H3/t11-/m0/s1
Senkyunolide A is one of the major ingredients in a traditional Chinese medicinal (TCM) herb Rhizoma Chuanxiong. This herb is derived from the dried rhizome of Ligusticum chuanxiong Hort (Umbelliferae) and is one of the most commonly used TCM herbs for the treatment of cardio and cerebrovascular diseases in China. Senkyunolide A has a low oral bioavailability. It has anti-cancer potential. Senkyunolide A may be considered as potential drug candidate for treating inflammatory processes associated with cerebrovascular diseases and related disorders based on their inhibitory activity on TNF-alpha production and TNF-alpha bioactivity.
Approval Year
Sourcing
PubMed
Patents
Sample Use Guides
Rat: About 1 mL of senkyunolide A (10 or 20 mg/mL) in normal saline containing 3% Tween 80 was given orally (100 mg/kg) or intraperitoneally (IP; 50 or 100 mg/kg). For the IV administration, about 0.2 mL of senkyunolide A (20 mg/mL, dose of 20 mg/kg) or Chuanxiong extract (100 mg/mL, dose of 100 mg/kg) was injected into femoral vein through the catheter.
Route of Administration:
Other
SUBSTANCE RECORD
