Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C12H16O2 |
| Molecular Weight | 192.2547 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCC[C@@]1([H])C2=C(C=CCC2)C(=O)O1
InChI
InChIKey=ZPIKVDODKLJKIN-NSHDSACASA-N
InChI=1S/C12H16O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h5,7,11H,2-4,6,8H2,1H3/t11-/m0/s1
| Molecular Formula | C12H16O2 |
| Molecular Weight | 192.2547 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Senkyunolide A is one of the major ingredients in a traditional Chinese medicinal (TCM) herb Rhizoma Chuanxiong. This herb is derived from the dried rhizome of Ligusticum chuanxiong Hort (Umbelliferae) and is one of the most commonly used TCM herbs for the treatment of cardio and cerebrovascular diseases in China. Senkyunolide A has a low oral bioavailability. It has anti-cancer potential. Senkyunolide A may be considered as potential drug candidate for treating inflammatory processes associated with cerebrovascular diseases and related disorders based on their inhibitory activity on TNF-alpha production and TNF-alpha bioactivity.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Antiproliferative effects of the traditional Chinese medicine shimotsu-to, its component cnidium rhizome and derived compounds on primary cultures of mouse aorta smooth muscle cells. | 1992 Dec |
|
| Phthalide Lactones from Ligusticum chuanxiong inhibit lipopolysaccharide-induced TNF-alpha production and TNF-alpha-mediated NF-kappaB Activation. | 2005 Sep |
|
| Low oral bioavailability and pharmacokinetics of senkyunolide a, a major bioactive component in Rhizoma Chuanxiong, in the rat. | 2007 Feb |
|
| Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells. | 2008 Oct 30 |
|
| Isolation and identification of anti-inflammatory constituents from Ligusticum chuanxiong and their underlying mechanisms of action on microglia. | 2011 May |
|
| Reinforcement of barrier function and scalp homeostasis by Senkyunolide A to fight against dandruff. | 2017 Dec |
Patents
Sample Use Guides
Rat: About 1 mL of senkyunolide A (10 or 20 mg/mL) in normal saline containing 3% Tween 80 was given orally (100 mg/kg) or intraperitoneally (IP; 50 or 100 mg/kg). For the IV administration, about 0.2 mL of senkyunolide A (20 mg/mL, dose of 20 mg/kg) or Chuanxiong extract (100 mg/mL, dose of 100 mg/kg) was injected into femoral vein through the catheter.
Route of Administration:
Other
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Jun 25 22:38:53 UTC 2021
by
admin
on
Fri Jun 25 22:38:53 UTC 2021
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| Record UNII |
74QZK813SO
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| Record Status |
Validated (UNII)
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| Record Version |
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63038-10-8
Created by
admin on Fri Jun 25 22:38:53 UTC 2021 , Edited by admin on Fri Jun 25 22:38:53 UTC 2021
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63038-10-8
Created by
admin on Fri Jun 25 22:38:53 UTC 2021 , Edited by admin on Fri Jun 25 22:38:53 UTC 2021
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PRIMARY | |||
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74QZK813SO
Created by
admin on Fri Jun 25 22:38:53 UTC 2021 , Edited by admin on Fri Jun 25 22:38:53 UTC 2021
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PRIMARY | |||
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3085257
Created by
admin on Fri Jun 25 22:38:53 UTC 2021 , Edited by admin on Fri Jun 25 22:38:53 UTC 2021
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