Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C10H15NO.H2O4S |
| Molecular Weight | 263.311 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OS(O)(=O)=O.CN[C@H](C)[C@@H](O)C1=CC=CC=C1
InChI
InChIKey=XVPDSDYVNYOVMP-GHXDPTCOSA-N
InChI=1S/C10H15NO.H2O4S/c1-8(11-2)10(12)9-6-4-3-5-7-9;1-5(2,3)4/h3-8,10-12H,1-2H3;(H2,1,2,3,4)/t8-,10-;/m1./s1
Racephedrine in combination with theophylline, phenobarbital was used to treat bronchial asthma. However, its application was substituted more effective agent. In addition, FDA has reviewed the final monograph for over-the-counter bronchodilator drug products to add additional warnings and to revise the indications in the labeling of products containing racephedrine hydrochloride.
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
79.4 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/973934/ |
22 mg single, oral dose: 22 mg route of administration: Oral experiment type: SINGLE co-administered: |
EPHEDRINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
751 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/973934/ |
22 mg single, oral dose: 22 mg route of administration: Oral experiment type: SINGLE co-administered: |
EPHEDRINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
6.75 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/973934/ |
22 mg single, oral dose: 22 mg route of administration: Oral experiment type: SINGLE co-administered: |
EPHEDRINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
PubMed
| Title | Date | PubMed |
|---|---|---|
| RACEPHEDRINE hydrochloride capsules. | 1949 Jul-Aug |
|
| A racephedrine-phenyltoloxamine-containing compound (Ephoxamine) in the treatment of bronchial asthma. | 1961 Jul |
|
| [Delayed-action effect of a racephedrine, theophylline and phenobarbital combination on asthma. Study on 100 cases]. | 1968 Jul-Aug |
|
| [The in-vitro histamine liberation in human leukocytes sensitized by grass pollen. Pharmacological application of the study on racephedrine and theophylline (proceedings)]. | 1977 Jun |
|
| Labeling for bronchodilators to treat asthma; cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the-counter human use. Final rule. | 2011 Jul 26 |
Patents
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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154-45-0
Created by
admin on Sat Dec 16 00:42:12 GMT 2023 , Edited by admin on Sat Dec 16 00:42:12 GMT 2023
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730X185N08
Created by
admin on Sat Dec 16 00:42:12 GMT 2023 , Edited by admin on Sat Dec 16 00:42:12 GMT 2023
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DTXSID40934890
Created by
admin on Sat Dec 16 00:42:12 GMT 2023 , Edited by admin on Sat Dec 16 00:42:12 GMT 2023
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20111738
Created by
admin on Sat Dec 16 00:42:12 GMT 2023 , Edited by admin on Sat Dec 16 00:42:12 GMT 2023
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205-828-8
Created by
admin on Sat Dec 16 00:42:12 GMT 2023 , Edited by admin on Sat Dec 16 00:42:12 GMT 2023
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ACTIVE MOIETY
SUBSTANCE RECORD
