Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H8N4O3 |
| Molecular Weight | 232.1955 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=NN=C(\C=C\C2=CC=C(O2)[N+]([O-])=O)C=C1
InChI
InChIKey=XDWLRMBWIWKFNC-HNQUOIGGSA-N
InChI=1S/C10H8N4O3/c11-9-5-2-7(12-13-9)1-3-8-4-6-10(17-8)14(15)16/h1-6H,(H2,11,13)/b3-1+
The nitrofuran derivative, nifurprazine, is a topical antibacterial agent used mainly for the treatment of animal diseases. It is a trypanocidal drug. Nifurprazine proved to be the most promising derivative since it was redox-cycled by both T. cruzi LipDH and TR and had pronounced antiparasitic effects in cultures of T. cruzi and Trypanosoma brucei.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Contact allergies due to nifurprazine (Carofur)]. | 1969 Aug 22 |
|
| [Microbiological demonstration of nifurprazine in body fluids and tissues of cattle]. | 1976 May |
|
| Nitrofuran drugs as common subversive substrates of Trypanosoma cruzi lipoamide dehydrogenase and trypanothione reductase. | 1999 Dec 1 |
Patents
Sample Use Guides
At concentrations of 100 uM, nifurprazine caused a 72% inhibition of trypanothione reductase (TR) activity. At 10 uM, nifurprazine inhibited parasite growth completely, but was also toxic to the mammalian host cells. Nifurprazine (3 uM) induced a 100% growth inhibition of T. brucei.
| Name | Type | Language | ||
|---|---|---|---|---|
|
Official Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
NCI_THESAURUS |
C28394
Created by
admin on Fri Dec 15 16:12:11 GMT 2023 , Edited by admin on Fri Dec 15 16:12:11 GMT 2023
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
6436113
Created by
admin on Fri Dec 15 16:12:11 GMT 2023 , Edited by admin on Fri Dec 15 16:12:11 GMT 2023
|
PRIMARY | |||
|
216-563-2
Created by
admin on Fri Dec 15 16:12:11 GMT 2023 , Edited by admin on Fri Dec 15 16:12:11 GMT 2023
|
PRIMARY | |||
|
1614-20-6
Created by
admin on Fri Dec 15 16:12:11 GMT 2023 , Edited by admin on Fri Dec 15 16:12:11 GMT 2023
|
PRIMARY | |||
|
SUB09275MIG
Created by
admin on Fri Dec 15 16:12:11 GMT 2023 , Edited by admin on Fri Dec 15 16:12:11 GMT 2023
|
PRIMARY | |||
|
2062
Created by
admin on Fri Dec 15 16:12:11 GMT 2023 , Edited by admin on Fri Dec 15 16:12:11 GMT 2023
|
PRIMARY | |||
|
CHEMBL2105219
Created by
admin on Fri Dec 15 16:12:11 GMT 2023 , Edited by admin on Fri Dec 15 16:12:11 GMT 2023
|
PRIMARY | |||
|
72ZUT1JIEB
Created by
admin on Fri Dec 15 16:12:11 GMT 2023 , Edited by admin on Fri Dec 15 16:12:11 GMT 2023
|
PRIMARY | |||
|
m846
Created by
admin on Fri Dec 15 16:12:11 GMT 2023 , Edited by admin on Fri Dec 15 16:12:11 GMT 2023
|
PRIMARY | Merck Index | ||
|
3796
Created by
admin on Fri Dec 15 16:12:11 GMT 2023 , Edited by admin on Fri Dec 15 16:12:11 GMT 2023
|
PRIMARY | |||
|
100000083895
Created by
admin on Fri Dec 15 16:12:11 GMT 2023 , Edited by admin on Fri Dec 15 16:12:11 GMT 2023
|
PRIMARY | |||
|
DTXSID40167141
Created by
admin on Fri Dec 15 16:12:11 GMT 2023 , Edited by admin on Fri Dec 15 16:12:11 GMT 2023
|
PRIMARY | |||
|
C90984
Created by
admin on Fri Dec 15 16:12:11 GMT 2023 , Edited by admin on Fri Dec 15 16:12:11 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
