Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C15H13N5OS |
| Molecular Weight | 311.362 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C(NCC1=CC=CC=C1)C2=CSC(NC3=NC=NC=C3)=N2
InChI
InChIKey=DOBKQCZBPPCLEG-UHFFFAOYSA-N
InChI=1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20)
DescriptionCurator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/19838168 |https://www.ncbi.nlm.nih.gov/pubmed/27647250
Curator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/19838168 |https://www.ncbi.nlm.nih.gov/pubmed/27647250
Thiazovivin is a novel ROCK (Rho-associated kinase) inhibitor and Rho-ROCK axis regulates cell-ECM and cell-cell adhesion. Recently was shown, that thiazovivin was effective for protecting the morphology and function of human corneal endothelial cells (HCECs). An optimal improvement in the morphology, connection and function of HCECs was found when the primary HCECs were cultured with thiazovivin.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Effect of a new ROCK inhibitor thiazovivin on the morphology and function of human corneal endothelial cells]. | 2016-09-11 |
|
| Thiazovivin, a Rho kinase inhibitor, improves stemness maintenance of embryo-derived stem-like cells under chemically defined culture conditions in cattle. | 2015-10 |
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| Reprogramming of endometrial adult stromal cells in the presence of a ROCK inhibitor, thiazovivin, could obtain more efficient iPSCs. | 2015-05 |
|
| Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. | 2010-05-04 |
|
| A chemical platform for improved induction of human iPSCs. | 2009-11 |
Patents
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46209426
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1226056-71-8
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7268XHE3P7
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DTXSID00673091
Created by
admin on Wed Apr 02 18:04:30 GMT 2025 , Edited by admin on Wed Apr 02 18:04:30 GMT 2025
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SUBSTANCE RECORD
