Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C15H13N5OS |
| Molecular Weight | 311.362 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C(NCC1=CC=CC=C1)C2=CSC(NC3=NC=NC=C3)=N2
InChI
InChIKey=DOBKQCZBPPCLEG-UHFFFAOYSA-N
InChI=1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20)
| Molecular Formula | C15H13N5OS |
| Molecular Weight | 311.362 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/19838168 |https://www.ncbi.nlm.nih.gov/pubmed/27647250
Curator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/19838168 |https://www.ncbi.nlm.nih.gov/pubmed/27647250
Thiazovivin is a novel ROCK (Rho-associated kinase) inhibitor and Rho-ROCK axis regulates cell-ECM and cell-cell adhesion. Recently was shown, that thiazovivin was effective for protecting the morphology and function of human corneal endothelial cells (HCECs). An optimal improvement in the morphology, connection and function of HCECs was found when the primary HCECs were cultured with thiazovivin.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A chemical platform for improved induction of human iPSCs. | 2009 Nov |
|
| Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. | 2010 May 4 |
|
| Reprogramming of endometrial adult stromal cells in the presence of a ROCK inhibitor, thiazovivin, could obtain more efficient iPSCs. | 2015 May |
|
| Thiazovivin, a Rho kinase inhibitor, improves stemness maintenance of embryo-derived stem-like cells under chemically defined culture conditions in cattle. | 2015 Oct |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 20:02:00 GMT 2023
by
admin
on
Sat Dec 16 20:02:00 GMT 2023
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| Record UNII |
7268XHE3P7
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| Record Status |
Validated (UNII)
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| Record Version |
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1226056-71-8
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7268XHE3P7
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admin on Sat Dec 16 20:02:00 GMT 2023 , Edited by admin on Sat Dec 16 20:02:00 GMT 2023
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