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Details

Stereochemistry MIXED
Molecular Formula C18H24I3N3O8
Molecular Weight 791.1119
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IOPROMIDE

SMILES

COCC(=O)NC1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)N(C)CC(O)CO)=C1I

InChI

InChIKey=DGAIEPBNLOQYER-UHFFFAOYSA-N
InChI=1S/C18H24I3N3O8/c1-24(4-9(28)6-26)18(31)12-13(19)11(17(30)22-3-8(27)5-25)14(20)16(15(12)21)23-10(29)7-32-2/h8-9,25-28H,3-7H2,1-2H3,(H,22,30)(H,23,29)

HIDE SMILES / InChI

Description

Iopromide is a molecule used as a contrast medium. It is a low osmolar, non-ionic contrast agent for intravascular use. It is commonly used in radiographic studies such as intravenous urograms, brain computer tomography (CT) and CT pulmonary angiograms (CTPAs). It appears to increase the risk of biguanide induced lactic acidosis. Interleukins are associated with an increased prevalence of delayed hypersensitivity reactions after iodinated contrast agent administration. Most common adverse reactions (>1%) are headache, nausea, injection site and infusion site reactions, vasodilatation, vomiting, back pain, urinary urgency, chest pain, pain, dysgeusia, and abnormal vision.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
ULTRAVIST 150
Diagnostic
ULTRAVIST 150
Diagnostic
ULTRAVIST 150

AUC

ValueDoseCo-administeredAnalytePopulation
13.2 mg × h/mL
80 g single, intravenous
IOPROMIDE plasma
Homo sapiens
2.3 mg × h/mL
15 g single, intravenous
IOPROMIDE plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
1.9 h
80 g single, intravenous
IOPROMIDE plasma
Homo sapiens
1.95 h
15 g single, intravenous
IOPROMIDE plasma
Homo sapiens

Funbound

ValueDoseCo-administeredAnalytePopulation
99%
unknown, unknown
IOPROMIDE plasma
Homo sapiens

Doses

Overview

OverviewOther

Drug as victim

PubMed

Sample Use Guides

In Vivo Use Guide
Intra-Arterial: Maximum Total Dose of Ultravist (iopromide) 300 mgI/mL for Cerebral Arteriography is 150 mL, for Peripheral Arteriography is 250 mL. Maximum Total Dose of Ultravist 370 mgI/mL for Coronary Arteriography and Left Ventriculography is 225 mL. Intravenous: Maximum Total Dose of Ultravist 300 mgI/mL for Excretory Urography is 100 mL. Maximum Total Dose of Ultravist 300 mgI/mL for Contrast Computed Tomography is 200 mL
Route of Administration: Other
In Vitro Use Guide
The thrombin time increased from approximately 20 seconds at an iopromide concentration of 10 mgI/mL, up to 100 seconds at an iopromide concentration of 70 mg I/mL.