CITIOLONE

Details

Stereochemistry	RACEMIC
Molecular Formula	C6H9NO2S
Molecular Weight	159.206
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)NC1CCSC1=O

InChI

InChIKey=NRFJZTXWLKPZAV-UHFFFAOYSA-N

InChI=1S/C6H9NO2S/c1-4(8)7-5-2-3-10-6(5)9/h5H,2-3H2,1H3,(H,7,8)

HIDE SMILES / InChI

Description
Sources: http://egypt-drug-index.blogspot.ru/2013/07/reducdyn-citiolonel-cysteine-for-acute.html

Citiolone (N-acetylhomocysteine thiolactone) is an antioxidant drug used in the treatment of liver diseases.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Oxidative Stress 160 Target ID: WP408 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9827694 \| https://www.ncbi.nlm.nih.gov/pubmed/1864487	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Liver diseases 14 Sources: https://www.ncbi.nlm.nih.gov/pubmed/917333 https://www.ncbi.nlm.nih.gov/pubmed/846658 https://www.ncbi.nlm.nih.gov/pubmed/5137693	Primary		Approved 8429	REDUCDYN Approved Use Reducdyn (Citiolone + L-Cysteine) is used for acute hepatitis, infections and toxic liver diseases, intoxications, side effects of irradiation, Allergic dermatoses, pruritis.

PubMed

Title	Date	PubMed
Methylmercury chloride-induced and antagonist-reverted succinic dehydrogenase changes in the brain and trigeminal ganglia of the rat.	1987 Jun	3034565
Acetyl-homocysteine thiolactone protects against some neurotoxic effects of thallium.	1989 Summer	2616067
Macrophages and antioxidant status in the NOD mouse pancreas.	1998 Dec 15	9827694
Organelle specific enzyme markers as indicators of methylmercury neurotoxicity and antidotal efficacy in mice.	2003 Jun	12572686

Patents

Sample Use Guides

In Vivo Use Guide

Reducdyn (Citiolone 50mg/tab. + L-Cysteine 50mg/tab): 3 tablets 3 times daily, to be swallowed whole with some liquid during or immediately after meals.

Route of Administration: Oral

In Vitro Use Guide

Human skin fibroblasts were irradiated following incubation with N-acetyl-homocysteine-thiolactone (citiolone (CIT), 1 mM). Treatments with CIT resulted in a significant rise in glutathione levels compared with control cells, with protection against UVA radiation.

Name

Type

Language

CITIOLONE

Official Name

English

CITIOLONE [MI]

Common Name

English

CITIOLONE [MART.]

Common Name

English

Citiolone [WHO-DD]

Common Name

English

citiolone [INN]

Common Name

English

NSC-22878

Code

English

N-(TETRAHYDRO-2-OXO-3-THIENYL)ACETAMIDE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29767