Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C11H17NO3.ClH |
| Molecular Weight | 247.719 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CC(C)NC[C@H](O)C1=CC=C(O)C(O)=C1
InChI
InChIKey=IROWCYIEJAOFOW-MERQFXBCSA-N
InChI=1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H/t11-;/m0./s1
Levisoprenaline (l-isoproterenol) is beta1- and beta2-adrenoreceptor agonist. In Japan, continuous inhalation of levisoprenaline is a recommended treatment for pediatric patients with acute severe exacerbation. Compared with salbutamol, l-isoproterenol reduced modified pulmonary index score more rapidly. But in most countries do not recommend continuous inhalation of l-isoproterenol to treat pediatric patients with acute severe exacerbation of asthma due to worsening asthma control. Levisoprenaline was used to cause experimental chronic heart failure in rats.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Method for non-invasively recording electrocardiograms in conscious mice. | 2001 |
|
| The hyperpolarization-activated current If in ventricular myocytes of non-transgenic and beta2-adrenoceptor overexpressing mice. | 2001 Aug |
|
| Autoantibodies against the beta1 adrenoceptor from patients with dilated cardiomyopathy prolong action potential duration and enhance contractility in isolated cardiomyocytes. | 2001 Aug |
|
| Identification and characterisation of beta-adrenoceptors on intact equine peripheral blood lymphocytes with the radioligand (-)-[125I]-iodocyanopindolol. | 2001 Sep |
|
| Sarcolemmal beta-adrenoceptors determined in rat ventricular heart biopsies with (-)-[3H]CGP-12177. | 2002 Oct |
|
| Pacemaker channels in mouse thalamocortical neurones are regulated by distinct pathways of cAMP synthesis. | 2004 Jan 1 |
|
| Possible role of dexamethasone in sensitizing the beta-2-adrenergic receptor system in vivo in calves during concomitant treatment with clenbuterol. | 2004 Nov |
|
| Development of a monoclonal antibody-based enzyme-linked immuosorbent assay for the beta-adrenergic agonist zilpaterol. | 2005 May 4 |
|
| Role of NO in the systemic hemodynamic response to beta2-adrenoceptor stimulation. | 2006 Aug |
|
| Neonatal murine heart slices. A robust model to study ventricular isometric contractions. | 2007 |
|
| Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs? | 2007 Jun 1 |
|
| Ligand-directed signaling at the beta3-adrenoceptor produced by 3-(2-Ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanol oxalate (SR59230A) relative to receptor agonists. | 2007 Nov |
|
| Distinct interactions of human beta1- and beta2-adrenoceptors with isoproterenol, epinephrine, norepinephrine, and dopamine. | 2008 Dec |
|
| Phosphodiesterases PDE3 and PDE4 jointly control the inotropic effects but not chronotropic effects of (-)-CGP12177 despite PDE4-evoked sinoatrial bradycardia in rat atrium. | 2009 Apr |
|
| Catecholamines relax detrusor through beta 2-adrenoceptors in mouse and beta 3-adrenoceptors in man. | 2009 Jan |
|
| Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes. | 2009 Jul-Aug |
|
| Cigarette smoke and lipopolysaccharide induce a proliferative airway smooth muscle phenotype. | 2010 Apr 29 |
|
| High concentrations of dexmedetomidine inhibit compound action potentials in frog sciatic nerves without alpha(2) adrenoceptor activation. | 2010 Aug |
|
| Beta1-adrenergic receptor activation decreases ANP release via cAMP-Ca2+ signaling in perfused beating rabbit atria. | 2010 Aug 14 |
|
| Receptor-mediated enhancement of beta adrenergic drug activity by ascorbate in vitro and in vivo. | 2010 Dec 13 |
|
| The laminin β1-competing peptide YIGSR induces a hypercontractile, hypoproliferative airway smooth muscle phenotype in an animal model of allergic asthma. | 2010 Dec 3 |
|
| Beta1-adrenoceptor polymorphism predicts flecainide action in patients with atrial fibrillation. | 2010 Jul 2 |
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| Code System | Code | Type | Description | ||
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656783
Created by
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100000138934
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m6533
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5984-95-2
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CHEMBL434
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SUB79394
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DTXSID4037243
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6X46C92UF9
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ACTIVE MOIETY
SUBSTANCE RECORD
