Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C11H17NO3.ClH |
| Molecular Weight | 247.719 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CC(C)NC[C@H](O)C1=CC=C(O)C(O)=C1
InChI
InChIKey=IROWCYIEJAOFOW-MERQFXBCSA-N
InChI=1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H/t11-;/m0./s1
Levisoprenaline (l-isoproterenol) is beta1- and beta2-adrenoreceptor agonist. In Japan, continuous inhalation of levisoprenaline is a recommended treatment for pediatric patients with acute severe exacerbation. Compared with salbutamol, l-isoproterenol reduced modified pulmonary index score more rapidly. But in most countries do not recommend continuous inhalation of l-isoproterenol to treat pediatric patients with acute severe exacerbation of asthma due to worsening asthma control. Levisoprenaline was used to cause experimental chronic heart failure in rats.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Method for non-invasively recording electrocardiograms in conscious mice. | 2001 |
|
| beta-Adrenoceptor blocking activities of nipradilol and its optical isomers in pig coronary artery. | 2001 Apr |
|
| The hyperpolarization-activated current If in ventricular myocytes of non-transgenic and beta2-adrenoceptor overexpressing mice. | 2001 Aug |
|
| Autoantibodies against the beta1 adrenoceptor from patients with dilated cardiomyopathy prolong action potential duration and enhance contractility in isolated cardiomyocytes. | 2001 Aug |
|
| Methanol solvent may cause increased apparent metabolic instability in in vitro assays. | 2001 Feb |
|
| beta(1)-Adrenoceptors compensate for beta(3)-adrenoceptors in ileum from beta(3)-adrenoceptor knock-out mice. | 2001 Jan |
|
| Identification and characterisation of beta-adrenoceptors on intact equine peripheral blood lymphocytes with the radioligand (-)-[125I]-iodocyanopindolol. | 2001 Sep |
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| Mouse beta 3a- and beta 3b-adrenoceptors expressed in Chinese hamster ovary cells display identical pharmacology but utilize distinct signalling pathways. | 2002 Apr |
|
| Comparison of the affinity of beta-blockers for two states of the beta 1-adrenoceptor in ferret ventricular myocardium. | 2002 Jan |
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| Similarities and differences in the coupling of human beta1- and beta2-adrenoceptors to Gs(alpha) splice variants. | 2002 Jul 1 |
|
| (-)-Isoproterenol modulation of maxi-K(+) channel in nonpigmented ciliary epithelial cells through a G-protein gated pathway. | 2002 Mar |
|
| Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): effect of pertussis toxin. | 2002 Nov |
|
| Sarcolemmal beta-adrenoceptors determined in rat ventricular heart biopsies with (-)-[3H]CGP-12177. | 2002 Oct |
|
| Regulation of equine lymphocyte beta-adrenoceptors under the influence of clenbuterol and dexamethasone. | 2002 Sep |
|
| Cardiostimulant and cardiodepressant effects through overexpressed human beta2-adrenoceptors in murine heart: regional differences and functional role of beta1-adrenoceptors. | 2003 Apr |
|
| Enhanced beta2-adrenergic receptor (beta2AR) signaling by adeno-associated viral (AAV)-mediated gene transfer. | 2003 Dec 4 |
|
| (-)-CGP 12177 increases contractile force and hastens relaxation of human myocardial preparations through a propranolol-resistant state of the beta 1-adrenoceptor. | 2003 Jan |
|
| Enzyme-linked immunosorbent assay development for the beta-adrenergic agonist zilpaterol. | 2004 Apr 21 |
|
| Pacemaker channels in mouse thalamocortical neurones are regulated by distinct pathways of cAMP synthesis. | 2004 Jan 1 |
|
| Binding of (-)-[3H]-CGP12177 at two sites in recombinant human beta 1-adrenoceptors and interaction with beta-blockers. | 2004 May |
|
| Markedly reduced effects of (-)-isoprenaline but not of (-)-CGP12177 and unchanged affinity of beta-blockers at Gly389-beta1-adrenoceptors compared to Arg389-beta1-adrenoceptors. | 2004 May |
|
| Aspartate138 is required for the high-affinity ligand binding site but not for the low-affinity binding site of the beta1-adrenoceptor. | 2004 Sep |
|
| Effects of immunoglobulin G from patients with dilated cardiomyopathy on rat cardiomyocytes. | 2005 Jun |
|
| Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs? | 2007 Jun 1 |
|
| Mutagenesis of important amino acid reveals unconventional homologous internalization of beta(1)-adrenergic receptor. | 2009 Aug 12 |
|
| Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes. | 2009 Jul-Aug |
|
| High concentrations of dexmedetomidine inhibit compound action potentials in frog sciatic nerves without alpha(2) adrenoceptor activation. | 2010 Aug |
|
| Beta1-adrenergic receptor activation decreases ANP release via cAMP-Ca2+ signaling in perfused beating rabbit atria. | 2010 Aug 14 |
|
| Receptor-mediated enhancement of beta adrenergic drug activity by ascorbate in vitro and in vivo. | 2010 Dec 13 |
|
| The laminin β1-competing peptide YIGSR induces a hypercontractile, hypoproliferative airway smooth muscle phenotype in an animal model of allergic asthma. | 2010 Dec 3 |
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656783
Created by
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100000138934
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m6533
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5984-95-2
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CHEMBL434
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SUB79394
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DTXSID4037243
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6X46C92UF9
Created by
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ACTIVE MOIETY
SUBSTANCE RECORD
