Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C11H17NO3.ClH |
| Molecular Weight | 247.719 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CC(C)NC[C@H](O)C1=CC=C(O)C(O)=C1
InChI
InChIKey=IROWCYIEJAOFOW-MERQFXBCSA-N
InChI=1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H/t11-;/m0./s1
| Molecular Formula | C11H17NO3 |
| Molecular Weight | 211.2576 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Levisoprenaline (l-isoproterenol) is beta1- and beta2-adrenoreceptor agonist. In Japan, continuous inhalation of levisoprenaline is a recommended treatment for pediatric patients with acute severe exacerbation. Compared with salbutamol, l-isoproterenol reduced modified pulmonary index score more rapidly. But in most countries do not recommend continuous inhalation of l-isoproterenol to treat pediatric patients with acute severe exacerbation of asthma due to worsening asthma control. Levisoprenaline was used to cause experimental chronic heart failure in rats.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Receptor-mediated enhancement of beta adrenergic drug activity by ascorbate in vitro and in vivo. | 2010-12-13 |
|
| The laminin β1-competing peptide YIGSR induces a hypercontractile, hypoproliferative airway smooth muscle phenotype in an animal model of allergic asthma. | 2010-12-03 |
|
| Beta1-adrenergic receptor activation decreases ANP release via cAMP-Ca2+ signaling in perfused beating rabbit atria. | 2010-08-14 |
|
| High concentrations of dexmedetomidine inhibit compound action potentials in frog sciatic nerves without alpha(2) adrenoceptor activation. | 2010-08 |
|
| Beta1-adrenoceptor polymorphism predicts flecainide action in patients with atrial fibrillation. | 2010-07-02 |
|
| Cigarette smoke and lipopolysaccharide induce a proliferative airway smooth muscle phenotype. | 2010-04-29 |
|
| Phosphodiesterases do not limit beta1-adrenoceptor-mediated sinoatrial tachycardia: evidence with PDE3 and PDE4 in rabbits and PDE1-5 in rats. | 2009-11 |
|
| Mutagenesis of important amino acid reveals unconventional homologous internalization of beta(1)-adrenergic receptor. | 2009-08-12 |
|
| Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes. | 2009-04-09 |
|
| Phosphodiesterases PDE3 and PDE4 jointly control the inotropic effects but not chronotropic effects of (-)-CGP12177 despite PDE4-evoked sinoatrial bradycardia in rat atrium. | 2009-04 |
|
| Catecholamines relax detrusor through beta 2-adrenoceptors in mouse and beta 3-adrenoceptors in man. | 2009-01 |
|
| Distinct interactions of human beta1- and beta2-adrenoceptors with isoproterenol, epinephrine, norepinephrine, and dopamine. | 2008-12 |
|
| Ligand-directed signaling at the beta3-adrenoceptor produced by 3-(2-Ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanol oxalate (SR59230A) relative to receptor agonists. | 2007-11 |
|
| Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs? | 2007-06-01 |
|
| In vitro and in vivo pharmacological characterization of ethyl-4-[trans-4-[((2S)-2-hydroxy-3-[4-hydroxy-3[(methylsulfonyl)amino]-phenoxy]propyl) amino]cyclohexyl]benzoate hydrochloride (SAR150640), a new potent and selective human beta3-adrenoceptor agonist for the treatment of preterm labor. | 2007-06 |
|
| The function of alpha- and beta-adrenoceptors of the saphenous artery in caveolin-1 knockout and wild-type mice. | 2007-02 |
|
| Neonatal murine heart slices. A robust model to study ventricular isometric contractions. | 2007 |
|
| Caveolin-1 knockout alters beta-adrenoceptors function in mouse small intestine. | 2006-12 |
|
| Interaction between autoantibodies against the beta1-adrenoceptor and isoprenaline in enhancing L-type Ca2+ current in rat ventricular myocytes. | 2006-10 |
|
| Pharmacological evaluation of plasma membrane beta-adrenoceptors in rat hearts using the tissue segment binding method. | 2006-08-01 |
|
| Role of NO in the systemic hemodynamic response to beta2-adrenoceptor stimulation. | 2006-08 |
|
| Multiple signalling pathways involved in beta2-adrenoceptor-mediated glucose uptake in rat skeletal muscle cells. | 2006-02 |
|
| Effects of immunoglobulin G from patients with dilated cardiomyopathy on rat cardiomyocytes. | 2005-06 |
|
| Development of a monoclonal antibody-based enzyme-linked immuosorbent assay for the beta-adrenergic agonist zilpaterol. | 2005-05-04 |
|
| Possible role of dexamethasone in sensitizing the beta-2-adrenergic receptor system in vivo in calves during concomitant treatment with clenbuterol. | 2004-11 |
|
| Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure. | 2004-09 |
|
| Aspartate138 is required for the high-affinity ligand binding site but not for the low-affinity binding site of the beta1-adrenoceptor. | 2004-09 |
|
| Agonist binding and activation of the rat beta(1)-adrenergic receptor: role of Trp(134(3.28)), Ser(190(4.57)) and Tyr(356(7.43)). | 2004-08-15 |
|
| Expression of functional beta2-adrenergic receptors in the lung epithelial cell lines 16HBE14o(-), Calu-3 and A549. | 2004-05-03 |
|
| Molecular characterization of pharmacological properties and selectivity of SWR-0315NA for beta3-adrenoceptors. | 2004-05 |
|
| Binding of (-)-[3H]-CGP12177 at two sites in recombinant human beta 1-adrenoceptors and interaction with beta-blockers. | 2004-05 |
|
| Markedly reduced effects of (-)-isoprenaline but not of (-)-CGP12177 and unchanged affinity of beta-blockers at Gly389-beta1-adrenoceptors compared to Arg389-beta1-adrenoceptors. | 2004-05 |
|
| Enzyme-linked immunosorbent assay development for the beta-adrenergic agonist zilpaterol. | 2004-04-21 |
|
| Pacemaker channels in mouse thalamocortical neurones are regulated by distinct pathways of cAMP synthesis. | 2004-01-01 |
|
| Characterization of beta 3-adrenoceptor-mediated relaxation in rat abdominal aorta smooth muscle. | 2003-12-15 |
|
| Enhanced beta2-adrenergic receptor (beta2AR) signaling by adeno-associated viral (AAV)-mediated gene transfer. | 2003-12-04 |
|
| Cardiostimulant and cardiodepressant effects through overexpressed human beta2-adrenoceptors in murine heart: regional differences and functional role of beta1-adrenoceptors. | 2003-04 |
|
| (-)-CGP 12177 increases contractile force and hastens relaxation of human myocardial preparations through a propranolol-resistant state of the beta 1-adrenoceptor. | 2003-01 |
|
| Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): effect of pertussis toxin. | 2002-11 |
|
| Sarcolemmal beta-adrenoceptors determined in rat ventricular heart biopsies with (-)-[3H]CGP-12177. | 2002-10 |
|
| Regulation of equine lymphocyte beta-adrenoceptors under the influence of clenbuterol and dexamethasone. | 2002-09 |
|
| Similarities and differences in the coupling of human beta1- and beta2-adrenoceptors to Gs(alpha) splice variants. | 2002-07-01 |
|
| Mouse beta 3a- and beta 3b-adrenoceptors expressed in Chinese hamster ovary cells display identical pharmacology but utilize distinct signalling pathways. | 2002-04 |
|
| (-)-Isoproterenol modulation of maxi-K(+) channel in nonpigmented ciliary epithelial cells through a G-protein gated pathway. | 2002-03 |
|
| Comparison of the affinity of beta-blockers for two states of the beta 1-adrenoceptor in ferret ventricular myocardium. | 2002-01 |
|
| Identification and characterisation of beta-adrenoceptors on intact equine peripheral blood lymphocytes with the radioligand (-)-[125I]-iodocyanopindolol. | 2001-09 |
|
| The hyperpolarization-activated current If in ventricular myocytes of non-transgenic and beta2-adrenoceptor overexpressing mice. | 2001-08 |
|
| Autoantibodies against the beta1 adrenoceptor from patients with dilated cardiomyopathy prolong action potential duration and enhance contractility in isolated cardiomyocytes. | 2001-08 |
|
| beta-Adrenoceptor blocking activities of nipradilol and its optical isomers in pig coronary artery. | 2001-04 |
|
| Method for non-invasively recording electrocardiograms in conscious mice. | 2001 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:27:25 GMT 2025
by
admin
on
Mon Mar 31 21:27:25 GMT 2025
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| Record UNII |
6X46C92UF9
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| Record Status |
Validated (UNII)
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| Record Version |
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