Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C6H6N4S |
| Molecular Weight | 166.204 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CSC1=C2NC=NC2=NC=N1
InChI
InChIKey=UIJIQXGRFSPYQW-UHFFFAOYSA-N
InChI=1S/C6H6N4S/c1-11-6-4-5(8-2-7-4)9-3-10-6/h2-3H,1H3,(H,7,8,9,10)
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Purine analogs as potential anticytomegalovirus agents. | 1969 Sep |
|
| Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells. | 2001 Aug 1 |
|
| Determination of thiopurine methyltransferase activity in human erythrocytes by high-performance liquid chromatography: comparison with the radiochemical method. | 2001 Oct |
|
| Determination of thiopurine S-methyltransferase phenotype using thin-layer chromatography and quantitative scanning. | 2002 Apr |
|
| Clinical significance of azathioprine active metabolite concentrations in inflammatory bowel disease. | 2004 Aug |
|
| Therapeutic drug monitoring of thiopurine drugs in patients with inflammatory bowel disease or autoimmune hepatitis. | 2004 Nov |
|
| Monitoring of long-term thiopurine therapy among adults with inflammatory bowel disease. | 2004 Nov |
|
| Improved HPLC methodology for monitoring thiopurine metabolites in patients on thiopurine therapy. | 2004 Sep |
|
| Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease. | 2005 Aug |
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| Prediction of genotoxicity of chemical compounds by statistical learning methods. | 2005 Jun |
|
| Determination of mercaptopurine and its four metabolites by large-volume sample stacking with polarity switching in capillary electrophoresis. | 2005 Jun |
|
| Liquid chromatography-tandem mass spectrometry analysis of erythrocyte thiopurine nucleotides and effect of thiopurine methyltransferase gene variants on these metabolites in patients receiving azathioprine/6-mercaptopurine therapy. | 2005 Nov |
|
| [HPLC determination and diversity analysis of thiopurine methyltransferase activity in human and pig]. | 2006 May |
|
| Utility of thiopurine methyltransferase genotyping and phenotyping, and measurement of azathioprine metabolites in the management of patients with autoimmune hepatitis. | 2006 Oct |
|
| Molecular mechanisms underlying the enhanced sensitivity of thiopurine-resistant T-lymphoblastic cell lines to methyl mercaptopurineriboside. | 2006 Sep 28 |
|
| Optimizing drug therapy in inflammatory bowel disease. | 2007 Dec |
|
| 6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial. | 2007 Jul |
|
| [Optimising azathioprine treatment: determination of thiopurine methyltransferase activity and thiopurine metabolites]. | 2009 Feb |
|
| Patent watch. Drug metabolite claims are patentable. | 2009 Nov |
|
| Steady-state of azathioprine during initiation treatment of pediatric inflammatory bowel disease. | 2010 Dec |
|
| Algorithms outperform metabolite tests in predicting response of patients with inflammatory bowel disease to thiopurines. | 2010 Feb |
|
| How should thiopurine treatment be monitored?--methodological aspects. | 2010 Jun |
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PARENT (METABOLITE INACTIVE)
SUBSTANCE RECORD
