6-METHYLMERCAPTOPURINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H6N4S
Molecular Weight	166.204
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CSC1=C2NC=NC2=NC=N1

InChI

InChIKey=UIJIQXGRFSPYQW-UHFFFAOYSA-N

InChI=1S/C6H6N4S/c1-11-6-4-5(8-2-7-4)9-3-10-6/h2-3H,1H3,(H,7,8,9,10)

HIDE SMILES / InChI

Molecular Formula	C6H6N4S
Molecular Weight	166.204
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Purine analogs as potential anticytomegalovirus agents.	1969 Sep	4309475
Determination of thiopurine methyltransferase activity in human erythrocytes by high-performance liquid chromatography: comparison with the radiochemical method.	2001 Oct	11591900
Prediction of genotoxicity of chemical compounds by statistical learning methods.	2005 Jun	15962942
Determination of mercaptopurine and its four metabolites by large-volume sample stacking with polarity switching in capillary electrophoresis.	2005 Jun	15934057
Utility of thiopurine methyltransferase genotyping and phenotyping, and measurement of azathioprine metabolites in the management of patients with autoimmune hepatitis.	2006 Oct	16876902
Evolution of thiopurine use in pediatric inflammatory bowel disease in an academic center.	2006 Sep	16954954
Molecular mechanisms underlying the enhanced sensitivity of thiopurine-resistant T-lymphoblastic cell lines to methyl mercaptopurineriboside.	2006 Sep 28	16859645
Optimizing drug therapy in inflammatory bowel disease.	2007 Dec	18377805
6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial.	2007 Jul	17495015
Population pharmacokinetic and pharmacogenetic analysis of 6-mercaptopurine in paediatric patients with acute lymphoblastic leukaemia.	2008 Dec	18823306
Initial clinical experience with allopurinol-thiopurine combination therapy in pediatric inflammatory bowel disease.	2008 Dec	18521913
Stability of thiopurine metabolites: a potential analytical bias.	2008 Jan	18160731
Steady-state of azathioprine during initiation treatment of pediatric inflammatory bowel disease.	2010 Dec	21122571
Algorithms outperform metabolite tests in predicting response of patients with inflammatory bowel disease to thiopurines.	2010 Feb	19835986
How should thiopurine treatment be monitored?--methodological aspects.	2010 Jun	20544507
A prospective evaluation of the impact of allopurinol in pediatric and adult IBD patients with preferential metabolism of 6-mercaptopurine to 6-methylmercaptopurine.	2010 Nov	21122558

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:05:54 GMT 2023` Edited by `admin` on `Fri Dec 15 17:05:54 GMT 2023`
Record UNII	6V404DV25O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

6-METHYLMERCAPTOPURINE

Systematic Name

English

NSC-20105

Code

English

METHYLMERCAPTOPURINE, 6-

Systematic Name

English

6-methylmercaptopurine [WHO-DD]

Common Name

English

6-(METHYLTHIO)PURINE

Systematic Name

English

Code System Code Type Description

PUBCHEM

5778