ABAMETAPIR

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H12N2
Molecular Weight	184.2371
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC=C(N=C1)C2=NC=C(C)C=C2

InChI

InChIKey=PTRATZCAGVBFIQ-UHFFFAOYSA-N

InChI=1S/C12H12N2/c1-9-3-5-11(13-7-9)12-6-4-10(2)8-14-12/h3-8H,1-2H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/29999197 | https://www.ncbi.nlm.nih.gov/pubmed/30828591

Hatchtech is developing abametapir, an organic heterocyclic small-molecule, for the treatment of pediculosis (head lice). Abametapir is an inhibitor of metalloproteinases critical for louse survival and egg development. Abametapir lotion, 0.74%, demonstrated significant ovicidal activity against head lice eggs with a single application.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
C-C chemokine receptor type 8 1 Target ID: CHEMBL4596 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22957890	Modulator 828	7943.28 nM [EC50]
C-C chemokine receptor type 1 11 Target ID: CHEMBL2413 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22957890	Modulator 828	17000.0 nM [EC50]
C-C chemokine receptor type 5 19 Target ID: CHEMBL274 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22957890	Modulator 828	2300.0 nM [EC50]

PubMed

Title	Date	PubMed
Synthesis of heteroleptic bis(diimine)carbonylchlororuthenium(II) complexes from photodecarbonylated precursors.	2004 May 3	15106968
Intramolecular metal...sulfur interactions of platinum(II) 1,4,7-trithiacyclononane complexes with bipyridyl ligands: the relationship between molecular and electronic structures.	2005 Mar 21	15762722
Studies of the interaction of tetramethylcucurbit[6]uril and 5,5'-dimethyl-2,2'-bipyridyl hydrochloride.	2007 Dec	17917750
Mechanism of quenching by oxygen of the excited states of ruthenium(II) complexes in aqueous media. Solvent isotope effect and photosensitized generation of singlet oxygen, O2(1Deltag), by [Ru(diimine)(CN)4]2- complex ions.	2007 Jun 28	17563787
5,5'-Bis[(trimethyl-silyl)meth-yl]-2,2'-bipyridine.	2008 Jan 4	21201396
(5,5'-Dimethyl-2,2'-bipyridine-κN,N')diiodidomercury(II).	2008 Sep 20	21201044
Dichlorido(2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline-κN,N')mercury(II) acetonitrile hemisolvate.	2009 Jul 1	21583318
Tetra-aqua-(5,5'-dimethyl-2,2'-bipyridine-κN,N')zinc(II) sulfate.	2009 Jul 4	21583333
5,5'-Dimethyl-2,2'-bipyridine.	2009 Jun 17	21582861
(2,9-Dimethyl-4,7-diphenyl-1,10-phen-anthroline-κN,N')bis-(thio-cyanato-κS)mercury(II).	2009 Jun 24	21582740
Capabilities of direct sample introduction--comprehensive two-dimensional gas chromatography--time-of-flight mass spectrometry to analyze organic chemicals of interest in fish oils.	2009 May 1	19534141
(2,2'-Biquinoline-κN,N')dichlorido-iron(II).	2009 Oct 17	21578122
Studies on bis(halogeno) dioxomolybdenum(VI)-bipyridine complexes: synthesis and catalytic activity.	2009 Oct 28	19809750
catena-Poly[[(5,5'-dimethyl-2,2'-bi-pyridine-κN,N')cadmium(II)]-di-μ-iodido].	2010 Apr 24	21579044

Patents

Sample Use Guides

In Vivo Use Guide

The efficacy of abametapir lotion, 0.74%, was assessed for its ability to clear head louse infestations after a single application. Abametapir lotion was applied to dry hair for 10 minutes on day 0 and then rinsed with water.

Route of Administration: Topical

Name

Type

Language

ABAMETAPIR

Official Name

English

ABAMETAPIR [USAN]

Common Name

English

ABAMETAPIR [MI]

Common Name

English

abametapir [INN]

Common Name

English

XEGLYZE

Brand Name

English

ABAMETAPIR [ORANGE BOOK]

Common Name

English

HA-44

Code

English

6,6'-BI-3-PICOLINE

Common Name

English

5,5'-DIMETHYL-2,2'-DIPYRIDYL

Common Name

English

HA44

Code

English

2,2'-BIPYRIDINE, 5,5'-DIMETHYL-

Systematic Name

English

Abametapir [WHO-DD]

Common Name

English

5,5'-DIMETHYL-2,2'-BIPYRIDINE

Systematic Name

English

Code System Code Type Description

PUBCHEM

15664