ABAMETAPIR

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H12N2
Molecular Weight	184.2371
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC=C(N=C1)C2=NC=C(C)C=C2

InChI

InChIKey=PTRATZCAGVBFIQ-UHFFFAOYSA-N

InChI=1S/C12H12N2/c1-9-3-5-11(13-7-9)12-6-4-10(2)8-14-12/h3-8H,1-2H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/29999197 | https://www.ncbi.nlm.nih.gov/pubmed/30828591

Hatchtech is developing abametapir, an organic heterocyclic small-molecule, for the treatment of pediculosis (head lice). Abametapir is an inhibitor of metalloproteinases critical for louse survival and egg development. Abametapir lotion, 0.74%, demonstrated significant ovicidal activity against head lice eggs with a single application.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
C-C chemokine receptor type 8 1 Target ID: CHEMBL4596 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22957890	Modulator 828	7943.28 nM [EC50]
C-C chemokine receptor type 1 11 Target ID: CHEMBL2413 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22957890	Modulator 828	17000.0 nM [EC50]
C-C chemokine receptor type 5 19 Target ID: CHEMBL274 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22957890	Modulator 828	2300.0 nM [EC50]

PubMed

Title	Date	PubMed
Synthesis of heteroleptic bis(diimine)carbonylchlororuthenium(II) complexes from photodecarbonylated precursors.	2004 May 3	15106968
Variability in the structures of [4-(aminomethyl)pyridine]silver(I) complexes through effects of ligand ratio, anion, hydrogen bonding, and pi-stacking.	2006 Jan 23	16411733
New members of the [Ru(diimine)(CN)(4)](2-) family: structural, electrochemical and photophysical properties.	2006 Jan 7	16357959
Mechanism of quenching by oxygen of the excited states of ruthenium(II) complexes in aqueous media. Solvent isotope effect and photosensitized generation of singlet oxygen, O2(1Deltag), by [Ru(diimine)(CN)4]2- complex ions.	2007 Jun 28	17563787
5,5'-Bis[(trimethyl-silyl)meth-yl]-2,2'-bipyridine.	2008 Jan 4	21201396
Dichlorido(6-methyl-2,2'-bipyridine-κN,N')zinc(II).	2008 Sep 13	21201019
(5,5'-Dimethyl-2,2'-bipyridine-κN,N')diiodidomercury(II).	2008 Sep 20	21201044
Dibromido(2,9-dimethyl-1,10-phenanthroline-κN,N')mercury(II).	2009 Apr 2	21583736
Diazido-bis(5,5'-dimethyl-2,2'-bipyridyl-κN,N')nickel(II) monohydrate.	2009 Aug 8	21577389
Bis[dichlorido(5,5'-dimethyl-2,2'-bi-pyridine-κN,N')gold(III)] tetra-chlorido-aurate(III) dichloridooaurate(I).	2009 Feb 28	21582104
Dichloridobis(phenanthridine-κN)zinc(II).	2009 Jun 6	21582680
Aqua-bis(benzoato-κO)(5,5'-dimethyl-2,2'-bipyridine-κN,N')copper(II).	2009 Oct 3	21578058
catena-Poly[[(5,5'-dimethyl-2,2'-bi-pyridine-κN,N')cadmium(II)]-di-μ-iodido].	2010 Apr 24	21579044
catena-Poly[[aqua-(5,5'-dimethyl-2,2'-bipyridine-κN,N')copper(II)]-μ-2,2'-oxydibenzoato-κO:O'].	2010 Jul 10	21588146
(2,2'-Dimethyl-4,4'-bi-1,3-thia-zole-κN,N')diiodidomercury(II).	2010 Jul 31	21588098
Tri-μ-sulfato-κO:O'-bis-[aqua-(1,10-phenanthroline-κN,N')indium(III)] dihydrate.	2010 Sep 15	21587408

Patents

Sample Use Guides

In Vivo Use Guide

The efficacy of abametapir lotion, 0.74%, was assessed for its ability to clear head louse infestations after a single application. Abametapir lotion was applied to dry hair for 10 minutes on day 0 and then rinsed with water.

Route of Administration: Topical

Name

Type

Language

ABAMETAPIR

Official Name

English

ABAMETAPIR [USAN]

Common Name

English

ABAMETAPIR [MI]

Common Name

English

abametapir [INN]

Common Name

English

XEGLYZE

Brand Name

English

ABAMETAPIR [ORANGE BOOK]

Common Name

English

HA-44

Code

English

6,6'-BI-3-PICOLINE

Common Name

English

5,5'-DIMETHYL-2,2'-DIPYRIDYL

Common Name

English

HA44

Code

English

2,2'-BIPYRIDINE, 5,5'-DIMETHYL-

Systematic Name

English

Abametapir [WHO-DD]

Common Name

English

5,5'-DIMETHYL-2,2'-BIPYRIDINE

Systematic Name

English

Code System Code Type Description

PUBCHEM

15664