Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H14O4 |
| Molecular Weight | 174.1944 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)CCCCCCC(O)=O
InChI
InChIKey=TYFQFVWCELRYAO-UHFFFAOYSA-N
InChI=1S/C8H14O4/c9-7(10)5-3-1-2-4-6-8(11)12/h1-6H2,(H,9,10)(H,11,12)
Suberic acid, also octanedioic acid, is a dicarboxylic acid, with formula C6H12(COOH)2. It is present in the urine of patients with fatty acid oxidation disorders. A metabolic breakdown product derived from oleic acid. Elevated levels of this unstaruated dicarboxylic acid are found in individuals with medium-chain acyl-CoA dehydrogenase deficiency (MCAD). Suberic acid is also found to be associated with carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, which are also inborn errors of metabolism. Suberic Acid is used in the preparation of reduction-sensitive micelles affecting their cellular uptake. This has potential application in delivery of anticancer drugs. It is also used in the fluorescent detection of amidinium-carboxylate and amidinium formation.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Microbial transformation of bile acids. A unified scheme for bile acid degradation, and hydroxylation of bile acids. | 1982 |
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| Inhibition of HIV-1 proteinase by non-peptide carboxylates. | 1991 Apr 15 |
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| Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease. | 1991 Jan 2 |
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| Physiology and pathophysiology of organic acids in cerebrospinal fluid. | 1993 |
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| Bissulfosuccinimidyl esters of aliphatic dicarboxylic acids: a new class of 'affinity directed' beta beta crosslinkers of HbA. | 1994 |
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| Age-related reference values for urinary organic acids in a healthy Turkish pediatric population. | 1994 Jun |
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| Measurements of urinary adipic acid and suberic acid using high-performance liquid chromatography. | 1994 May 13 |
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| Average structure of the composite crystal urea/octanedioic acid at room temperature within the superspace formalism. | 2001 Jun |
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| The first case of 4-hydroxybutyric aciduria in Japan. | 2001 Mar |
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| [Late-onset riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency (glutaric aciduria type II)]. | 2003 Dec |
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| Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. | 2003 Oct |
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| The first suberate lanthanum(III) complex without uncoordinated water. | 2004 Aug |
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| Solvent-mediated folding of a doubly charged anion. | 2004 Jan 28 |
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| Bulk versus interfacial aqueous solvation of dicarboxylate dianions. | 2004 Sep 22 |
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| Synthesis, Superoxide Dismutase Mimetic and Anticancer Activities of Metal Complexes of 2,2-Dimethylpentanedioic Acid(2dmepdaH(2)) and 3,3-Dimethylpentanedioic acid(3dmepdaH(2)): X-Ray Crystal Structures of [Cu(3dmepda)(bipy)](2). 6H(2)O and [Cu(2dmepda)(bipy)(EtOH)](2). 4EtOH (bipy = 2,2'Bipyridine). | 2006 |
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| A dimeric cobalt(II)-suberate complex with 3-aminopyridine. | 2006 Nov |
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| Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 Nov |
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| (Heptanedioato-κO,O')bis-(1,10-phenanthroline-κN,N')zinc(II) hexa-hydrate. | 2008 Mar 7 |
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| Synthesis, Binding and Fluorescence Studies of Bis-2-amidopyrrole Receptors for Bis-carboxylate Anions. | 2009 |
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| Radiation metabolomics. 3. Biomarker discovery in the urine of gamma-irradiated rats using a simplified metabolomics protocol of gas chromatography-mass spectrometry combined with random forests machine learning algorithm. | 2009 Aug |
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| New 2-methylimidazole-dicarboxylic acid molecular crystals: crystal structure and proton conductivity. | 2009 Aug 26 |
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| 2,2'-Hexamethyl-enedi-1,3-benzothia-zole. | 2009 Jan 14 |
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| Metabolic profiling of Parkinson's disease: evidence of biomarker from gene expression analysis and rapid neural network detection. | 2009 Jul 13 |
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| Direct Repeat 6 from human herpesvirus-6B encodes a nuclear protein that forms a complex with the viral DNA processivity factor p41. | 2009 Oct 15 |
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| 2-Amino-6-methyl-1,3-benzothia-zole-octa-nedioic acid (2/1). | 2009 Oct 23 |
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6U7Y4M9C1H
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9300
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2044370
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10457
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SUBERIC ACID
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208-010-9
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C005738
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DTXSID8021644
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505-48-6
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m10262
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25952
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SUBSTANCE RECORD
