Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H14O4 |
| Molecular Weight | 174.1944 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)CCCCCCC(O)=O
InChI
InChIKey=TYFQFVWCELRYAO-UHFFFAOYSA-N
InChI=1S/C8H14O4/c9-7(10)5-3-1-2-4-6-8(11)12/h1-6H2,(H,9,10)(H,11,12)
| Molecular Formula | C8H14O4 |
| Molecular Weight | 174.1944 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Suberic acid, also octanedioic acid, is a dicarboxylic acid, with formula C6H12(COOH)2. It is present in the urine of patients with fatty acid oxidation disorders. A metabolic breakdown product derived from oleic acid. Elevated levels of this unstaruated dicarboxylic acid are found in individuals with medium-chain acyl-CoA dehydrogenase deficiency (MCAD). Suberic acid is also found to be associated with carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, which are also inborn errors of metabolism. Suberic Acid is used in the preparation of reduction-sensitive micelles affecting their cellular uptake. This has potential application in delivery of anticancer drugs. It is also used in the fluorescent detection of amidinium-carboxylate and amidinium formation.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Microbial transformation of bile acids. A unified scheme for bile acid degradation, and hydroxylation of bile acids. | 1982 |
|
| Prenatal diagnosis of glutaric aciduria type II by direct chemical analysis of dicarboxylic acids in amniotic fluid. | 1984 Jan |
|
| Inhibition of HIV-1 proteinase by non-peptide carboxylates. | 1991 Apr 15 |
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| Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease. | 1991 Jan 2 |
|
| Physiology and pathophysiology of organic acids in cerebrospinal fluid. | 1993 |
|
| Bissulfosuccinimidyl esters of aliphatic dicarboxylic acids: a new class of 'affinity directed' beta beta crosslinkers of HbA. | 1994 |
|
| Age-related reference values for urinary organic acids in a healthy Turkish pediatric population. | 1994 Jun |
|
| Measurements of urinary adipic acid and suberic acid using high-performance liquid chromatography. | 1994 May 13 |
|
| Average structure of the composite crystal urea/octanedioic acid at room temperature within the superspace formalism. | 2001 Jun |
|
| Structure-activity relationships for a large diverse set of natural, synthetic, and environmental estrogens. | 2001 Mar |
|
| The first case of 4-hydroxybutyric aciduria in Japan. | 2001 Mar |
|
| Steryl and stanyl esters of fatty acids by solvent-free esterification and transesterification in vacuo using lipases from Rhizomucor miehei, Candida antarctica, and Carica papaya. | 2001 Nov |
|
| Neuromuscular blocking activity and therapeutic potential of mixed-tetrahydroisoquinolinium halofumarates and halosuccinates in rhesus monkeys. | 2003 Jun 5 |
|
| Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. | 2003 Oct |
|
| Solvent-mediated folding of a doubly charged anion. | 2004 Jan 28 |
|
| Synthesis, Superoxide Dismutase Mimetic and Anticancer Activities of Metal Complexes of 2,2-Dimethylpentanedioic Acid(2dmepdaH(2)) and 3,3-Dimethylpentanedioic acid(3dmepdaH(2)): X-Ray Crystal Structures of [Cu(3dmepda)(bipy)](2). 6H(2)O and [Cu(2dmepda)(bipy)(EtOH)](2). 4EtOH (bipy = 2,2'Bipyridine). | 2006 |
|
| A dimeric cobalt(II)-suberate complex with 3-aminopyridine. | 2006 Nov |
|
| Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 Nov |
|
| Determination of insulin in innovative formulations by means of LC coupled to fluorescence detection. | 2008 Dec 15 |
|
| (Heptanedioato-κO,O')bis-(1,10-phenanthroline-κN,N')zinc(II) hexa-hydrate. | 2008 Mar 7 |
|
| Metabolomic profiling of dietary-induced insulin resistance in the high fat-fed C57BL/6J mouse. | 2008 Sep |
|
| Synthesis, Binding and Fluorescence Studies of Bis-2-amidopyrrole Receptors for Bis-carboxylate Anions. | 2009 |
|
| Radiation metabolomics. 3. Biomarker discovery in the urine of gamma-irradiated rats using a simplified metabolomics protocol of gas chromatography-mass spectrometry combined with random forests machine learning algorithm. | 2009 Aug |
|
| New 2-methylimidazole-dicarboxylic acid molecular crystals: crystal structure and proton conductivity. | 2009 Aug 26 |
|
| 2,2'-Hexamethyl-enedi-1,3-benzothia-zole. | 2009 Jan 14 |
|
| Metabolic profiling of Parkinson's disease: evidence of biomarker from gene expression analysis and rapid neural network detection. | 2009 Jul 13 |
|
| Direct Repeat 6 from human herpesvirus-6B encodes a nuclear protein that forms a complex with the viral DNA processivity factor p41. | 2009 Oct 15 |
|
| 2-Amino-6-methyl-1,3-benzothia-zole-octa-nedioic acid (2/1). | 2009 Oct 23 |
|
| Evidence for alternative quaternary structure in a bacterial Type III secretion system chaperone. | 2010 Jul 15 |
|
| Cow's milk allergy is associated with changes in urinary organic acid concentrations. | 2010 Mar |
|
| Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509). | 2010 Nov 30 |
|
| Enhanced immunogenicity of stabilized trimeric soluble influenza hemagglutinin. | 2010 Sep 1 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:59:25 UTC 2023
by
admin
on
Fri Dec 15 15:59:25 UTC 2023
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| Record UNII |
6U7Y4M9C1H
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| Record Status |
Validated (UNII)
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| Record Version |
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6U7Y4M9C1H
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9300
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2044370
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10457
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SUBERIC ACID
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208-010-9
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C005738
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DTXSID8021644
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505-48-6
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m10262
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25952
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