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Details

Stereochemistry ACHIRAL
Molecular Formula C10H13N2O3.Na
Molecular Weight 232.2116
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of APROBARBITAL SODIUM

SMILES

[Na+].CC(C)C1(CC=C)C(=O)NC(=O)[N-]C1=O

InChI

InChIKey=HLFOAHHCDKJHCJ-UHFFFAOYSA-M
InChI=1S/C10H14N2O3.Na/c1-4-5-10(6(2)3)7(13)11-9(15)12-8(10)14;/h4,6H,1,5H2,2-3H3,(H2,11,12,13,14,15);/q;+1/p-1

HIDE SMILES / InChI
Aprobarbital is a barbiturate derivative. Aprobarbital have been used for the short-term treatment of insomnia and for routine sedation to relieve anxiety, tension, and apprehension however, barbiturates generally have been replaced by benzodiazepines.

Originator

Curator's Comment: On Saturday, March 12, 1927, a U.S. federal trademark registration was filed for ALURATE (trade name for Aprobarbital) by Hoffmann-La Roche Inc.. According to Wikipedia Aprobarbital was invented in the 1920s by Ernst Preiswerk (No additional reference available). # Hoffmann-La Roche Inc.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
ALURATE

Approved Use

Aprobarbital have been used for the short-term treatment of insomnia and for routine sedation to relieve anxiety, tension, and apprehension however, barbiturates generally have been replaced by benzodiazepines.

Launch Date

1927
Primary
ALURATE

Approved Use

Aprobarbital have been used for the short-term treatment of insomnia and for routine sedation to relieve anxiety, tension, and apprehension however, barbiturates generally have been replaced by benzodiazepines.

Launch Date

1927
PubMed

PubMed

TitleDatePubMed
Permanent impairment of renal function after methicillin nephropathy.
1971 Nov 13
Determinations of zidovudine/didanosine/nevirapine and zidovudine/didanosine/ritonavir in human serum by micellar electrokinetic chromatography.
2002 Nov 7
Determination of lamivudine/stavudine/efavirenz in human serum using liquid chromatography/electrospray tandem mass spectrometry with ionization polarity switch.
2002 Sep
The history of barbiturates a century after their clinical introduction.
2005 Dec
Occurrence and fate of barbiturates in the aquatic environment.
2006 Dec 1
Patents

Patents

Sample Use Guides

Usual adult dose Hypnotic: Oral, 40 to 160 mg at bedtime. Sedative: Daytime—Oral, 40 mg three times a day.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
APROBARBITAL SODIUM
Common Name English
ALUBARB
Brand Name English
APROBARBITONE SODIUM
Common Name English
APROTAL
Brand Name English
SOMNIPRON
Brand Name English
APROBARBITAL SODIUM SALT
MI  
Common Name English
ARBATAL
Brand Name English
SODIUM APROBARBITAL
Common Name English
2,4,6(1H,3H,5H)-PYRIMIDINETRIONE, 5-(1-METHYLETHYL)-5-(2- PROPENYL)-, MONOSODIUM SALT
Common Name English
5-ALLYL-5-ISOPROPYLBARBITURIC ACID SODIUM SALT
Common Name English
BARITAL
Brand Name English
SODIUM 5-ALLYL-5-ISOPROPYLBARBITURATE
Systematic Name English
APROBARBITAL SODIUM SALT [MI]
Common Name English
NSC-120767
Code English
ALURATE SODIUM
Brand Name English
NERVOLITAN
Brand Name English
Classification Tree Code System Code
DEA NO. 2100
Created by admin on Sat Dec 16 01:57:35 GMT 2023 , Edited by admin on Sat Dec 16 01:57:35 GMT 2023
Code System Code Type Description
NSC
120767
Created by admin on Sat Dec 16 01:57:35 GMT 2023 , Edited by admin on Sat Dec 16 01:57:35 GMT 2023
PRIMARY
MERCK INDEX
m2015
Created by admin on Sat Dec 16 01:57:35 GMT 2023 , Edited by admin on Sat Dec 16 01:57:35 GMT 2023
PRIMARY Merck Index
PUBCHEM
23662380
Created by admin on Sat Dec 16 01:57:35 GMT 2023 , Edited by admin on Sat Dec 16 01:57:35 GMT 2023
PRIMARY
CAS
125-88-2
Created by admin on Sat Dec 16 01:57:35 GMT 2023 , Edited by admin on Sat Dec 16 01:57:35 GMT 2023
PRIMARY
DRUG BANK
DBSALT002230
Created by admin on Sat Dec 16 01:57:35 GMT 2023 , Edited by admin on Sat Dec 16 01:57:35 GMT 2023
PRIMARY
ECHA (EC/EINECS)
204-760-6
Created by admin on Sat Dec 16 01:57:35 GMT 2023 , Edited by admin on Sat Dec 16 01:57:35 GMT 2023
PRIMARY
FDA UNII
6T90V76R18
Created by admin on Sat Dec 16 01:57:35 GMT 2023 , Edited by admin on Sat Dec 16 01:57:35 GMT 2023
PRIMARY