Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C16H21N |
| Molecular Weight | 227.3446 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C1CN(C1)C2CCCC\C2=C/C3=CC=CC=C3
InChI
InChIKey=DOWWDQZIFWLREB-FYWRMAATSA-N
InChI=1S/C16H21N/c1-2-7-14(8-3-1)13-15-9-4-5-10-16(15)17-11-6-12-17/h1-3,7-8,13,16H,4-6,9-12H2/b15-13+
Tazadolene was developed as a novel non-opioid analgesic with antidepressant properties. Experiments on rodents have revealed that unique analgesia properties of tazadolene was due to the ability of this compound to activate both serotonergic and alpha 2 adrenergic antinociceptive systems. Information about the current use of this drug is not available.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Reversed-phase high-performance liquid chromatographic assay for the determination of potency and impurities in tazadolene succinate bulk drug and capsules. | 1986 Feb 26 |
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| Tazadolene succinate: a structurally novel non-opioid analgesic with antidepressant properties. | 1986 Nov |
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| Evidence for the combined involvement of serotonergic and alpha 2 adrenergic mechanisms in the analgesic activity of tazadolene succinate. | 1987 Dec |
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| Isolation, identification and synthesis of a metabolite of tazadolene succinate. | 1987 Feb |
Patents
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C2198
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C152520
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6OLQ55F914
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
