TAZADOLENE SUCCINATE

Details

Stereochemistry	RACEMIC
Molecular Formula	C16H21N.C4H6O4
Molecular Weight	345.4327
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CCC(O)=O.C1CN(C1)C2CCCC\C2=C/C3=CC=CC=C3

InChI

InChIKey=IEXXCIWKNWOEKZ-GVYCEHEKSA-N

InChI=1S/C16H21N.C4H6O4/c1-2-7-14(8-3-1)13-15-9-4-5-10-16(15)17-11-6-12-17;5-3(6)1-2-4(7)8/h1-3,7-8,13,16H,4-6,9-12H2;1-2H2,(H,5,6)(H,7,8)/b15-13+;

HIDE SMILES / InChI

Molecular Formula	C4H6O4
Molecular Weight	118.088
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C16H21N
Molecular Weight	227.3446
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	1
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2855569

Tazadolene was developed as a novel non-opioid analgesic with antidepressant properties. Experiments on rodents have revealed that unique analgesia properties of tazadolene was due to the ability of this compound to activate both serotonergic and alpha 2 adrenergic antinociceptive systems. Information about the current use of this drug is not available.

Approval Year

PubMed

Title	Date	PubMed
Evidence for the combined involvement of serotonergic and alpha 2 adrenergic mechanisms in the analgesic activity of tazadolene succinate.	1987-12	2855569
Isolation, identification and synthesis of a metabolite of tazadolene succinate.	1987-02	3509335
Tazadolene succinate: a structurally novel non-opioid analgesic with antidepressant properties.	1986-11	3509323
Reversed-phase high-performance liquid chromatographic assay for the determination of potency and impurities in tazadolene succinate bulk drug and capsules.	1986-02-26	3700522

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:14:53 GMT 2025` Edited by `admin` on `Mon Mar 31 19:14:53 GMT 2025`
Record UNII	20L521S4UL
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TAZADOLENE SUCCINATE

Official Name

English

U-53,996H

Preferred Name

English

BUTANEDIOIC ACID, COMPD. WITH 1-((2E)-2-(PHENYLMETHYLENE)CYCLOHEXYL)AZETIDINE (1:1)

Systematic Name

English

TAZADOLENE SUCCINATE [USAN]

Common Name

English

U-53996H

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C2198