DIPHENYLGUANIDINE

US Approved Allergenic Extract (1994)

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H13N3
Molecular Weight	211.2624
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N=C(NC1=CC=CC=C1)NC2=CC=CC=C2

InChI

InChIKey=OWRCNXZUPFZXOS-UHFFFAOYSA-N

InChI=1S/C13H13N3/c14-13(15-11-7-3-1-4-8-11)16-12-9-5-2-6-10-12/h1-10H,(H3,14,15,16)

HIDE SMILES / InChI

Description
Sources: http://www.fda.gov/downloads/BiologicsBloodVaccines/Allergenics/UCM294327.pdf
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/11965241

Diphenylguanidine (DPG) has been used as a primary and secondary accelerator in the vulcanization of rubber. Exposure to DPG may occur as a result of dermal contact during rubber manufacture or from contact with the finished products. DPG is poorly absorbed through skin. It can be found in latex gloves and other rubber products found in homes and offices. Diphenylguanidine is a standardized chemical allergen. It is used for diagnosis of contact allergy. It is a component of Carba Mix, used in the epicutaneous patch test, called T.R.U.E. TEST, approved by FDA in 1994. T.R.U.E. TEST is indicated for use as an aid in the diagnosis of allergic contact dermatitis in persons 18 years of age and older whose history suggests sensitivity to one or more of the 35 substances included on the T.R.U.E. TEST panels.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Allergic contact dermatitis 14 Sources: http://www.fda.gov/downloads/BiologicsBloodVaccines/Allergenics/UCM294327.pdf	Diagnostic		Approved 8583	T.R.U.E. TEST Approved Use T.R.U.E. TEST is an epicutaneous patch test indicated for use as an aid in the diagnosis of allergic contact dermatitis in persons 18 years of age and older whose history suggests sensitivity to one or more of the 35 substances included on the T.R.U.E. TEST panels. Launch Date 1993

PubMed

Title	Date	PubMed
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.	2011-07-14	21599003
Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels.	2011-05-01	21362439
Allergic contact dermatitis to synthetic rubber gloves: changing trends in patch test reactions to accelerators.	2010-09	20855699
Lymphomatoid allergic contact dermatitis mimicking cutaneous T cell lymphoma.	2010-07-22	20646676
An 8-year retrospective review of patch testing with rubber allergens: the Mayo Clinic experience.	2010-02-09	20137737
Study of molecularly imprinted solid-phase extraction of diphenylguanidine and its structural analogs.	2009-04-20	19345756
A novel reactivity mode for metal-activated dialkylcyanamide species: addition of N,N'-diphenylguanidine to a cis-(R2NCN)2Pt(II) center giving an eight-membered chelated platinaguanidine.	2009-03-16	19220004
Novel tailoring reaction for two adjacent coordinated nitriles giving platinum 1,3,5-triazapentadiene complexes.	2008-12-15	18376821
Identification of an unknown extraneous contaminant in pharmaceutical product analysis.	2007-12-21	17928183
Glove allergy due to 1,3-diphenylguanidine.	2006-01	16426298
Simultaneous sodium lauryl sulphate testing improves the diagnostic validity of allergic patch tests. Results from a prospective multicentre study of the German Contact Dermatitis Research Group (Deutsche Kontaktallergie-Gruppe, DKG).	2005-04	15840103
Occupational rubber glove allergy: results of the Information Network of Departments of Dermatology (IVDK), 1995-2001.	2003-01	12641577

Patents

Sample Use Guides

In Vivo Use Guide

Apply the three adhesive panels of allergens and allergen mixes on healthy skin of the back. Remove panels and evaluate the skin 48 hours after application. Re-evaluate the skin 72 to 96 hours after application.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Name

Type

Language

DIPHENYLGUANIDINE

Systematic Name

English

1,3-DIPHENYLGUANIDINE

Preferred Name

English

1,3-DIPHENYLGUANIDINE [MI]

Common Name

English

DPG

Common Name

English

NSC-3272

Code

English

N,N'-DIPHENYLGUANIDINE [HSDB]

Common Name

English

NOCCELER D

Brand Name

English

N,N'-DIPHENYLGUANIDINE

Systematic Name

English

Classification Tree Code System Code

NDF-RT

N0000185508