DIPHENYLGUANIDINE

US Approved Allergenic Extract (1994)

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H13N3
Molecular Weight	211.2624
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N=C(NC1=CC=CC=C1)NC2=CC=CC=C2

InChI

InChIKey=OWRCNXZUPFZXOS-UHFFFAOYSA-N

InChI=1S/C13H13N3/c14-13(15-11-7-3-1-4-8-11)16-12-9-5-2-6-10-12/h1-10H,(H3,14,15,16)

HIDE SMILES / InChI

Molecular Formula	C13H13N3
Molecular Weight	211.2624
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.fda.gov/downloads/BiologicsBloodVaccines/Allergenics/UCM294327.pdf
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/11965241

Diphenylguanidine (DPG) has been used as a primary and secondary accelerator in the vulcanization of rubber. Exposure to DPG may occur as a result of dermal contact during rubber manufacture or from contact with the finished products. DPG is poorly absorbed through skin. It can be found in latex gloves and other rubber products found in homes and offices. Diphenylguanidine is a standardized chemical allergen. It is used for diagnosis of contact allergy. It is a component of Carba Mix, used in the epicutaneous patch test, called T.R.U.E. TEST, approved by FDA in 1994. T.R.U.E. TEST is indicated for use as an aid in the diagnosis of allergic contact dermatitis in persons 18 years of age and older whose history suggests sensitivity to one or more of the 35 substances included on the T.R.U.E. TEST panels.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Allergic contact dermatitis 14 Sources: http://www.fda.gov/downloads/BiologicsBloodVaccines/Allergenics/UCM294327.pdf	Diagnostic		Approved 8583	T.R.U.E. TEST Approved Use T.R.U.E. TEST is an epicutaneous patch test indicated for use as an aid in the diagnosis of allergic contact dermatitis in persons 18 years of age and older whose history suggests sensitivity to one or more of the 35 substances included on the T.R.U.E. TEST panels. Launch Date 1993

PubMed

Title	Date	PubMed
Simultaneous sodium lauryl sulphate testing improves the diagnostic validity of allergic patch tests. Results from a prospective multicentre study of the German Contact Dermatitis Research Group (Deutsche Kontaktallergie-Gruppe, DKG).	2005 Apr	15840103
Glove allergy due to 1,3-diphenylguanidine.	2006 Jan	16426298
Identification of an unknown extraneous contaminant in pharmaceutical product analysis.	2007 Dec 21	17928183
Novel tailoring reaction for two adjacent coordinated nitriles giving platinum 1,3,5-triazapentadiene complexes.	2008 Dec 15	18376821
Study of molecularly imprinted solid-phase extraction of diphenylguanidine and its structural analogs.	2009 Apr 20	19345756
A novel reactivity mode for metal-activated dialkylcyanamide species: addition of N,N'-diphenylguanidine to a cis-(R2NCN)2Pt(II) center giving an eight-membered chelated platinaguanidine.	2009 Mar 16	19220004
An 8-year retrospective review of patch testing with rubber allergens: the Mayo Clinic experience.	2010 Jan-Feb	20137737
Lymphomatoid allergic contact dermatitis mimicking cutaneous T cell lymphoma.	2010 Jul-Aug	20646676
Allergic contact dermatitis to synthetic rubber gloves: changing trends in patch test reactions to accelerators.	2010 Sep	20855699
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.	2011 Jul 14	21599003
Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels.	2011 May 1	21362439

Patents

Sample Use Guides

In Vivo Use Guide

Apply the three adhesive panels of allergens and allergen mixes on healthy skin of the back. Remove panels and evaluate the skin 48 hours after application. Re-evaluate the skin 72 to 96 hours after application.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:01:45 GMT 2025` Edited by `admin` on `Mon Mar 31 18:01:45 GMT 2025`
Record UNII	6MRZ85RNHQ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DIPHENYLGUANIDINE

Systematic Name

English

1,3-DIPHENYLGUANIDINE

Preferred Name

English

1,3-DIPHENYLGUANIDINE [MI]

Common Name

English

DPG

Common Name

English

NSC-3272

Code

English

N,N'-DIPHENYLGUANIDINE [HSDB]

Common Name

English

NOCCELER D

Brand Name

English

N,N'-DIPHENYLGUANIDINE

Systematic Name

English

Classification Tree Code System Code

NDF-RT

N0000185508