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Details

Stereochemistry ACHIRAL
Molecular Formula C13H13N3
Molecular Weight 211.2624
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIPHENYLGUANIDINE

SMILES

N=C(NC1=CC=CC=C1)NC2=CC=CC=C2

InChI

InChIKey=OWRCNXZUPFZXOS-UHFFFAOYSA-N
InChI=1S/C13H13N3/c14-13(15-11-7-3-1-4-8-11)16-12-9-5-2-6-10-12/h1-10H,(H3,14,15,16)

HIDE SMILES / InChI

Molecular Formula C13H13N3
Molecular Weight 211.2624
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/11965241

Diphenylguanidine (DPG) has been used as a primary and secondary accelerator in the vulcanization of rubber. Exposure to DPG may occur as a result of dermal contact during rubber manufacture or from contact with the finished products. DPG is poorly absorbed through skin. It can be found in latex gloves and other rubber products found in homes and offices. Diphenylguanidine is a standardized chemical allergen. It is used for diagnosis of contact allergy. It is a component of Carba Mix, used in the epicutaneous patch test, called T.R.U.E. TEST, approved by FDA in 1994. T.R.U.E. TEST is indicated for use as an aid in the diagnosis of allergic contact dermatitis in persons 18 years of age and older whose history suggests sensitivity to one or more of the 35 substances included on the T.R.U.E. TEST panels.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
T.R.U.E. TEST

Approved Use

T.R.U.E. TEST is an epicutaneous patch test indicated for use as an aid in the diagnosis of allergic contact dermatitis in persons 18 years of age and older whose history suggests sensitivity to one or more of the 35 substances included on the T.R.U.E. TEST panels.

Launch Date

1993
PubMed

PubMed

TitleDatePubMed
Occupational rubber glove allergy: results of the Information Network of Departments of Dermatology (IVDK), 1995-2001.
2003 Jan
Simultaneous sodium lauryl sulphate testing improves the diagnostic validity of allergic patch tests. Results from a prospective multicentre study of the German Contact Dermatitis Research Group (Deutsche Kontaktallergie-Gruppe, DKG).
2005 Apr
Glove allergy due to 1,3-diphenylguanidine.
2006 Jan
Identification of an unknown extraneous contaminant in pharmaceutical product analysis.
2007 Dec 21
Novel tailoring reaction for two adjacent coordinated nitriles giving platinum 1,3,5-triazapentadiene complexes.
2008 Dec 15
Lymphomatoid allergic contact dermatitis mimicking cutaneous T cell lymphoma.
2010 Jul-Aug
Allergic contact dermatitis to synthetic rubber gloves: changing trends in patch test reactions to accelerators.
2010 Sep
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
2011 Jul 14
Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels.
2011 May 1
Patents

Sample Use Guides

Apply the three adhesive panels of allergens and allergen mixes on healthy skin of the back. Remove panels and evaluate the skin 48 hours after application. Re-evaluate the skin 72 to 96 hours after application.
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:34:49 GMT 2023
Edited
by admin
on Fri Dec 15 15:34:49 GMT 2023
Record UNII
6MRZ85RNHQ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DIPHENYLGUANIDINE
Systematic Name English
1,3-DIPHENYLGUANIDINE [MI]
Common Name English
DPG
Common Name English
NSC-3272
Code English
N,N'-DIPHENYLGUANIDINE [HSDB]
Common Name English
NOCCELER D
Brand Name English
1,3-DIPHENYLGUANIDINE
MI  
Systematic Name English
N,N'-DIPHENYLGUANIDINE
HSDB  
Systematic Name English
Classification Tree Code System Code
NDF-RT N0000185508
Created by admin on Fri Dec 15 15:34:49 GMT 2023 , Edited by admin on Fri Dec 15 15:34:49 GMT 2023
Code System Code Type Description
HSDB
5345
Created by admin on Fri Dec 15 15:34:49 GMT 2023 , Edited by admin on Fri Dec 15 15:34:49 GMT 2023
PRIMARY
CAS
102-06-7
Created by admin on Fri Dec 15 15:34:49 GMT 2023 , Edited by admin on Fri Dec 15 15:34:49 GMT 2023
PRIMARY
ECHA (EC/EINECS)
203-002-1
Created by admin on Fri Dec 15 15:34:49 GMT 2023 , Edited by admin on Fri Dec 15 15:34:49 GMT 2023
PRIMARY
RXCUI
1368170
Created by admin on Fri Dec 15 15:34:49 GMT 2023 , Edited by admin on Fri Dec 15 15:34:49 GMT 2023
PRIMARY RxNorm
DRUG BANK
DB14191
Created by admin on Fri Dec 15 15:34:49 GMT 2023 , Edited by admin on Fri Dec 15 15:34:49 GMT 2023
PRIMARY
NDF-RT
N0000184306
Created by admin on Fri Dec 15 15:34:49 GMT 2023 , Edited by admin on Fri Dec 15 15:34:49 GMT 2023
PRIMARY Cell-mediated Immunity [PE]
MESH
C027773
Created by admin on Fri Dec 15 15:34:49 GMT 2023 , Edited by admin on Fri Dec 15 15:34:49 GMT 2023
PRIMARY
SMS_ID
100000134266
Created by admin on Fri Dec 15 15:34:49 GMT 2023 , Edited by admin on Fri Dec 15 15:34:49 GMT 2023
PRIMARY
EVMPD
SUB61025
Created by admin on Fri Dec 15 15:34:49 GMT 2023 , Edited by admin on Fri Dec 15 15:34:49 GMT 2023
PRIMARY
MERCK INDEX
m4628
Created by admin on Fri Dec 15 15:34:49 GMT 2023 , Edited by admin on Fri Dec 15 15:34:49 GMT 2023
PRIMARY Merck Index
NDF-RT
N0000171131
Created by admin on Fri Dec 15 15:34:49 GMT 2023 , Edited by admin on Fri Dec 15 15:34:49 GMT 2023
PRIMARY Allergens [Chemical/Ingredient]
NSC
3272
Created by admin on Fri Dec 15 15:34:49 GMT 2023 , Edited by admin on Fri Dec 15 15:34:49 GMT 2023
PRIMARY
FDA UNII
6MRZ85RNHQ
Created by admin on Fri Dec 15 15:34:49 GMT 2023 , Edited by admin on Fri Dec 15 15:34:49 GMT 2023
PRIMARY
EPA CompTox
DTXSID3025178
Created by admin on Fri Dec 15 15:34:49 GMT 2023 , Edited by admin on Fri Dec 15 15:34:49 GMT 2023
PRIMARY
CHEBI
144319
Created by admin on Fri Dec 15 15:34:49 GMT 2023 , Edited by admin on Fri Dec 15 15:34:49 GMT 2023
PRIMARY
PUBCHEM
7594
Created by admin on Fri Dec 15 15:34:49 GMT 2023 , Edited by admin on Fri Dec 15 15:34:49 GMT 2023
PRIMARY
DAILYMED
6MRZ85RNHQ
Created by admin on Fri Dec 15 15:34:49 GMT 2023 , Edited by admin on Fri Dec 15 15:34:49 GMT 2023
PRIMARY
NDF-RT
N0000175629
Created by admin on Fri Dec 15 15:34:49 GMT 2023 , Edited by admin on Fri Dec 15 15:34:49 GMT 2023
PRIMARY Increased Histamine Release [PE]
Related Record Type Details
ACTIVE MOIETY