DROBULINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H25NO
Molecular Weight	283.4079
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)NCC(O)CC(C1=CC=CC=C1)C2=CC=CC=C2

InChI

InChIKey=DAIZVBCVNQSHLI-UHFFFAOYSA-N

InChI=1S/C19H25NO/c1-15(2)20-14-18(21)13-19(16-9-5-3-6-10-16)17-11-7-4-8-12-17/h3-12,15,18-21H,13-14H2,1-2H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/692260 | Hathway. D.E. (2007) Foreign Compound Metabolism in Mammals, page 237, retrieved from: https://books.google.ru/books?id=6m8oDwAAQBAJ | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 471, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Drobuline is a potent cardiac depressant (anti-arrhythmic) agent, which has been found to be effective against ventricular arrhythmias in dogs. This compound is a racemic mixture having a single center of optical activity. The two isomers of drobuline were found to be equally potent in converting cardiac arrhythmias in dogs after intravenous administration. The major route of biotransformation of drobuline in the dog was shown to be conjugation with glucuronic acid.

Approval Year

PubMed

Title	Date	PubMed
Stereoselectivity in the metabolism of drobuline (d1--1- (isopropylamino) -4,4-diphenyl-2-butanol) a new anti-arrhythmic agent.	1978 Jul 24	692260

Sample Use Guides

In Vivo Use Guide

Single dose - 10 mg/kg

Route of Administration: Oral

Name

Type

Language

DROBULINE

Official Name

English

BENZENEPROPANOL, .ALPHA.-(((1-METHYLETHYL)AMINO)METHYL)-.GAMMA.-PHENYL-

Systematic Name

English

BENZENEPROPANOL, .ALPHA.-(((1-METHYLETHYL)AMINO)METHYL)-G-PHENYL-, (±)-

Common Name

English

drobuline [INN]

Common Name

English

COMPOUND-122587

Code

English

DROBULINE [USAN]

Common Name

English

COMPOUND 122587

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C47793