DROBULINE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H25NO.ClH
Molecular Weight	319.869
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC(C)NCC(O)CC(C1=CC=CC=C1)C2=CC=CC=C2

InChI

InChIKey=YKYKDSHUKOVMBU-UHFFFAOYSA-N

InChI=1S/C19H25NO.ClH/c1-15(2)20-14-18(21)13-19(16-9-5-3-6-10-16)17-11-7-4-8-12-17;/h3-12,15,18-21H,13-14H2,1-2H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C19H25NO
Molecular Weight	283.4079
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/692260 | Hathway. D.E. (2007) Foreign Compound Metabolism in Mammals, page 237, retrieved from: https://books.google.ru/books?id=6m8oDwAAQBAJ | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 471, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Drobuline is a potent cardiac depressant (anti-arrhythmic) agent, which has been found to be effective against ventricular arrhythmias in dogs. This compound is a racemic mixture having a single center of optical activity. The two isomers of drobuline were found to be equally potent in converting cardiac arrhythmias in dogs after intravenous administration. The major route of biotransformation of drobuline in the dog was shown to be conjugation with glucuronic acid.

Approval Year

PubMed

Title	Date	PubMed
Stereoselectivity in the metabolism of drobuline (d1--1- (isopropylamino) -4,4-diphenyl-2-butanol) a new anti-arrhythmic agent.	1978 Jul 24	692260

Sample Use Guides

In Vivo Use Guide

Single dose - 10 mg/kg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:19:00 GMT 2023` Edited by `admin` on `Fri Dec 15 15:19:00 GMT 2023`
Record UNII	52T4RU1IDL
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DROBULINE HYDROCHLORIDE

Common Name

English

NSC-301202

Code

English

BENZENEPROPANOL, .ALPHA.-(((1-METHYLETHYL)AMINO)METHYL)-.GAMMA.-PHENYL-, HYDROCHLORIDE, (±)-

Systematic Name

English

BENZENEPROPANOL, .ALPHA.-(((1-METHYLETHYL)AMINO)METHYL)-.GAMMA.-PHENYL-, HYDROCHLORIDE

Systematic Name

English

(±)-1-(ISOPROPYLAMINO)-4,4-DIPHENYL-2-BUTANOL HYDROCHLORIDE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47793