Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | 2F.Ni |
| Molecular Weight | 96.6902 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[F-].[F-].[Ni++]
InChI
InChIKey=DBJLJFTWODWSOF-UHFFFAOYSA-L
InChI=1S/2FH.Ni/h2*1H;/q;;+2/p-2
DescriptionSources: http://www.tera.org/ART/Nickel/Ni%20main%20text.PDFhttp://nj.gov/health/eoh/rtkweb/documents/fs/1346.pdfhttp://www.espimetals.com/index.php/676-msds/nickel-fluoride/692-nickel-fluoridehttps://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr451.pdfhttp://nj.gov/health/eoh/rtkweb/documents/fs/1342.pdfhttp://www.tuks.nl/WFCProject/pdf/Electrodepositon_of_Nickel.pdfhttps://monographs.iarc.fr/ENG/Monographs/vol100C/mono100C-10.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27748567 | https://www.ncbi.nlm.nih.gov/pubmed/27824316Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/8187719
Sources: http://www.tera.org/ART/Nickel/Ni%20main%20text.PDFhttp://nj.gov/health/eoh/rtkweb/documents/fs/1346.pdfhttp://www.espimetals.com/index.php/676-msds/nickel-fluoride/692-nickel-fluoridehttps://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr451.pdfhttp://nj.gov/health/eoh/rtkweb/documents/fs/1342.pdfhttp://www.tuks.nl/WFCProject/pdf/Electrodepositon_of_Nickel.pdfhttps://monographs.iarc.fr/ENG/Monographs/vol100C/mono100C-10.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27748567 | https://www.ncbi.nlm.nih.gov/pubmed/27824316
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/8187719
Nickel(II) chloride (NiCl2), a water soluble salt of Nickel, is a toxic and carcinogenic environmental and occupational pollutant, which has been shown to be carcinogenic to the lungs and nasal passages, in cases of long-term inhalation exposure. It was approved that NiCl2 was a potential genotoxicity caused indirect DNA damage by the production of ROS. In addition was conducted studies to evaluate the precise mechanism of Ni toxicology. And it was shown, thet NiCl2 induced and caused cell cycle G2/M phase arrest via p53-dependent pathway and generated inflammatory response by NF-κB pathway activation.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: map04064 |
|||
Target ID: GO:0044839 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | ECZEMOL Approved UseEczemol® is indicated for the treatment of moderate to severe eczema and atopic dermatitis. It has been found to work well with a variety of combination therapies. |
|||
PubMed
| Title | Date | PubMed |
|---|---|---|
| Carcinogenicity of nickel(II)hydroxides and nickel(II)sulfate in Wistar rats and its relation to the in vitro dissolution rates. | 1983 |
|
| Risk assessment of nickel carcinogenicity and occupational lung cancer. | 1994 Jan |
|
| Deliberations and evaluations of the approaches, endpoints and paradigms for dietary recommendations of the other trace elements. | 1996 Sep |
|
| Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study. | 1999 May |
|
| Molecular biology of nickel carcinogenesis: identification of differentially expressed genes in morphologically transformed C3H10T1/2 Cl 8 mouse embryo fibroblast cell lines induced by specific insoluble nickel compounds. | 2004 Jan |
|
| Down-regulation of the expression of the FIH-1 and ARD-1 genes at the transcriptional level by nickel and cobalt in the human lung adenocarcinoma A549 cell line. | 2005 Apr |
|
| Hypoxia regulation of expression and angiogenic effects of vasoactive intestinal peptide (VIP) and VIP receptors in LNCaP prostate cancer cells. | 2006 Apr 25 |
|
| Toll-like receptor priming sensitizes macrophages to proinflammatory cytokine gene induction by deoxynivalenol and other toxicants. | 2006 Aug |
|
| Nickel compounds render anti-apoptotic effect to human bronchial epithelial Beas-2B cells by induction of cyclooxygenase-2 through an IKKbeta/p65-dependent and IKKalpha- and p50-independent pathway. | 2006 Dec 22 |
|
| Soluble nickel inhibits HIF-prolyl-hydroxylases creating persistent hypoxic signaling in A549 cells. | 2006 Jul |
|
| Alterations of histone modifications and transgene silencing by nickel chloride. | 2006 Jul |
|
| Ni(II) activates the Nrf2 signaling pathway in human monocytic cells. | 2006 Nov |
|
| Effect of soluble nickel on cellular energy metabolism in A549 cells. | 2006 Oct |
|
| Effect of mercury, cadmium, nickel, chromium and zinc on kinetic properties of NADPH-cytochrome P450 reductase purified from leaping mullet (Liza saliens). | 2007 Apr |
|
| GPR39 signaling is stimulated by zinc ions but not by obestatin. | 2007 Jan |
|
| The contact allergen nickel triggers a unique inflammatory and proangiogenic gene expression pattern via activation of NF-kappaB and hypoxia-inducible factor-1alpha. | 2007 Mar 1 |
|
| Immunosuppressive effect of subchronic exposure to a mixture of eight heavy metals, found as groundwater contaminants in different areas of India, through drinking water in male rats. | 2007 Oct |
|
| Effects of nickel, chromate, and arsenite on histone 3 lysine methylation. | 2009 Apr 1 |
|
| GSH-dependent iNOS and HO-1 mediated apoptosis of human Jurkat cells induced by nickel(II). | 2009 Aug |
|
| Soluble and insoluble nickel compounds exert a differential inhibitory effect on cell growth through IKKalpha-dependent cyclin D1 down-regulation. | 2009 Jan |
|
| Exposure to nickel, chromium, or cadmium causes distinct changes in the gene expression patterns of a rat liver derived cell line. | 2011 |
|
| Interactions of a pesticide/heavy metal mixture in marine bivalves: a transcriptomic assessment. | 2011 Apr 16 |
|
| A novel DC therapy with manipulation of MKK6 gene on nickel allergy in mice. | 2011 Apr 22 |
|
| Nickel differentially regulates NFAT and NF-κB activation in T cell signaling. | 2011 Aug 1 |
|
| Effect of metals on β-actin and total protein synthesis in cultured human intestinal epithelial cells. | 2011 Jan-Feb |
|
| Nickel promotes the invasive potential of human lung cancer cells via TLR4/MyD88 signaling. | 2011 Jul 11 |
|
| Nickel-induced down-regulation of ΔNp63 and its role in the proliferation of keratinocytes. | 2011 Jun 15 |
|
| Nodal-mediated epigenesis requires dynamin-mediated endocytosis. | 2011 Mar |
|
| Effects of nickel treatment on H3K4 trimethylation and gene expression. | 2011 Mar 24 |
|
| L-carnitine protects against nickel-induced neurotoxicity by maintaining mitochondrial function in Neuro-2a cells. | 2011 May 15 |
|
| Nickel(II) induced JNK activation-regulated mitochondria-dependent apoptotic pathway leading to cultured rat pancreatic β-cell death. | 2011 Nov 18 |
|
| Does mechanism matter? Unrelated neurotoxicants converge on cell cycle and apoptosis during neurodifferentiation. | 2012 Jul |
|
| Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation. | 2012 Jul 20 |
|
| Nickel ion inhibits nuclear factor-kappa B activity in human oral squamous cell carcinoma. | 2013 |
|
| GADD45α induction by nickel negatively regulates JNKs/p38 activation via promoting PP2Cα expression. | 2013 |
|
| p53 activation by Ni(II) is a HIF-1α independent response causing caspases 9/3-mediated apoptosis in human lung cells. | 2013 Jun 15 |
|
| Differential gene expression profile of the calanoid copepod, Pseudodiaptomus annandalei, in response to nickel exposure. | 2013 Mar |
|
| Effect of Ni(II) on inflammatory gene expression in THP1 monocytic cells. | 2013 Mar |
|
| The toxic effects of nickel chloride on liver, erythropoiesis, and development in Wistar albino preimplanted rats can be reversed with selenium pretreatment. | 2013 May |
|
| Dietary nickel chloride restrains the development of small intestine in broilers. | 2013 Nov |
|
| Anti-apoptotic proteins and catalase-dependent apoptosis resistance in nickel chloride-transformed human lung epithelial cells. | 2013 Sep |
|
| Nickel-induced cell death and survival pathways in cultured renal proximal tubule cells: roles of reactive oxygen species, ceramide and ABCB1. | 2014 Apr |
|
| Nickel induces interleukin-1β secretion via the NLRP3-ASC-caspase-1 pathway. | 2014 Apr |
|
| MiRNA-210 modulates a nickel-induced cellular energy metabolism shift by repressing the iron-sulfur cluster assembly proteins ISCU1/2 in Neuro-2a cells. | 2014 Feb 27 |
|
| Genotoxic changes to rodent cells exposed in vitro to tungsten, nickel, cobalt and iron. | 2014 Mar 10 |
|
| The effect of divalent metal cations on zinc uptake by mouse Zrt/Irt-like protein 1 (ZIP1). | 2014 Sep 15 |
|
| Impact of cadmium, cobalt and nickel on sequence-specific DNA binding of p63 and p73 in vitro and in cells. | 2015 Jan 2 |
|
| Innate stimulatory capacity of high molecular weight transition metals Au (gold) and Hg (mercury). | 2015 Mar |
|
| Differential Toxicities of Nickel Salts to the Nematode Caenorhabditis elegans. | 2016 Aug |
|
| Involvement of L-type Ca²⁺ channel and toll-like receptor-4 in nickel-induced interleukin-8 gene expression. | 2016 Jan |
Patents
Sample Use Guides
Less than 0.1 mg Ni/day (<0.001 mg Ni/kg/day for a 70 kg adult).
Route of Administration:
Oral
The effect of 44 different metal salts on the activity of the reverse transcriptase
(RT) of the human immunodeficiency virus was investigated in vitro. For each metal compound, at least two concentrations were tested (10^-4 M and 10^-5 M). At 100 uM and 10 uM Ni2+ inhibited the RT activity on 5% and 11% of the control, respectively.
| Name | Type | Language | ||
|---|---|---|---|---|
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
m7863
Created by
admin on Sat Dec 16 04:01:53 GMT 2023 , Edited by admin on Sat Dec 16 04:01:53 GMT 2023
|
PRIMARY | Merck Index | ||
|
10028-18-9
Created by
admin on Sat Dec 16 04:01:53 GMT 2023 , Edited by admin on Sat Dec 16 04:01:53 GMT 2023
|
PRIMARY | |||
|
NICKEL(II) FLUORIDE
Created by
admin on Sat Dec 16 04:01:53 GMT 2023 , Edited by admin on Sat Dec 16 04:01:53 GMT 2023
|
PRIMARY | |||
|
233-071-3
Created by
admin on Sat Dec 16 04:01:53 GMT 2023 , Edited by admin on Sat Dec 16 04:01:53 GMT 2023
|
PRIMARY | |||
|
DTXSID5064912
Created by
admin on Sat Dec 16 04:01:53 GMT 2023 , Edited by admin on Sat Dec 16 04:01:53 GMT 2023
|
PRIMARY | |||
|
69NBB20493
Created by
admin on Sat Dec 16 04:01:53 GMT 2023 , Edited by admin on Sat Dec 16 04:01:53 GMT 2023
|
PRIMARY | |||
|
24825
Created by
admin on Sat Dec 16 04:01:53 GMT 2023 , Edited by admin on Sat Dec 16 04:01:53 GMT 2023
|
PRIMARY | |||
|
1826
Created by
admin on Sat Dec 16 04:01:53 GMT 2023 , Edited by admin on Sat Dec 16 04:01:53 GMT 2023
|
PRIMARY |
SUBSTANCE RECORD
