PARETHOXYCAINE

US Previously Marketed

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H23NO3
Molecular Weight	265.348
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC1=CC=C(C=C1)C(=O)OCCN(CC)CC

InChI

InChIKey=OWWVHQUOYSPNNE-UHFFFAOYSA-N

InChI=1S/C15H23NO3/c1-4-16(5-2)11-12-19-15(17)13-7-9-14(10-8-13)18-6-3/h7-10H,4-6,11-12H2,1-3H3

HIDE SMILES / InChI

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/6681975
Curator's Comment: Description was created using several sources including: http://www.ncbi.nlm.nih.gov/pubmed/5755894 https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA215&lpg=PA215&dq=PARETHOXYCAINE+was+developed+by&source=bl&ots=R3QAjHIrB5&sig=Qf1Lc12DBhPI8GED195f8oYqv3A&hl=en&sa=X&ved=0ahUKEwjG9ZnS6q7LAhUEcz4KHaX1DwEQ6AEIHjAB#v=onepage&q=PARETHOXYCAINE%20was%20developed%20by&f=false; http://www.annualreviews.org/doi/abs/10.1146/annurev.pa.09.040169.002443?journalCode=pharmtox.1&; http://journals.lww.com/anesthesia-analgesia/Citation/1952/11000/Intracaine_in_Oil_for_Caudal_Anesthesia_and.20.aspx

Parethoxycaine (Intracaine) is an ester series local anesthetic agent. It has been used by topical application mainly for mouth and throat.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614 Sources: http://www.google.com.tj/patents/US2431553	Primary		Preclinical	Intracaine Approved Use Unknown

Doses

Dose	Population	Adverse events
5 % 3 times / week multiple, topical Studied dose Dose: 5 %, 3 times / week Route: topical Route: multiple Dose: 5 %, 3 times / week Sources: https://pubmed.ncbi.nlm.nih.gov/18892064/	healthy, 34 years n = 1 Health Status: healthy Age Group: 34 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/18892064/	Other AEs: Pruritus... Other AEs: Pruritus Sources: https://pubmed.ncbi.nlm.nih.gov/18892064/

AEs

AE	Significance	Dose	Population
Pruritus		5 % 3 times / week multiple, topical Studied dose Dose: 5 %, 3 times / week Route: topical Route: multiple Dose: 5 %, 3 times / week Sources: https://pubmed.ncbi.nlm.nih.gov/18892064/	healthy, 34 years n = 1 Health Status: healthy Age Group: 34 years Sex: M Population Size: 1 Sources: https://pubmed.ncbi.nlm.nih.gov/18892064/

Sourcing

Vendor/Aggregator	ID	URL
ABI Chem	AC1L1O71
Alfa Chemistry	94-23-5	https://www.alfa-chemistry.com/cas_94-23-5.htm
Ambinter	Amb1817122	http://www.ambinter.com/reference/1817122
AsisChem	G00475
Aurora Fine Chemicals LLC	A12.865.000	http://online.aurorafinechemicals.com/info?ID=A12.865.000
Aurora Fine Chemicals LLC	K02.232.516	http://online.aurorafinechemicals.com/info?ID=K02.232.516
BOC Sciences	136-46-9
ChemBridge	6771521
ChemTik	CTK5H6001
Chemieliva Pharmaceutical Co., Ltd	PBCM1008192
Chemspace	CSSS00025767298	https://chem-space.com/CSSS00025767298
Enamine	Z252849086
IBScreen	STOCK2S-96942
Lab Network	LN00541670
Lab Network	LN01214070
MolPort	MolPort-000-743-709
MolPort	MolPort-002-221-761
MuseChem	M070671
MuseChem	M214997
NovoSeek	7183
Parchem	102183	https://www.parchem.com/chemical-supplier-distributor/2-Diethylaminoethyl-4-Ethoxybenzoate-102183.aspx
Pharmeks	PHAR058781
Princeton BioMolecular Research	OSSK_579829
Scientific Exchange	F-033683
Sigma Aldrich	PH014090
Sigma Aldrich	PH014090\|ALDRICH
Smolecule	S584930	https://www.smolecule.com/products/s584930
Specs	AO-365/40892107
Vitas-M Laboratory	STK095500
ZINC	ZINC000001833029	http://zinc15.docking.org/substances/ZINC000001833029
eMolecules	2415457
eMolecules	300058689
eMolecules	4471674
mcule	MCULE-8009544048	https://mcule.com/MCULE-8009544048/

PubMed

Title	Date	PubMed
[Relation between the physical-chemical properties, chemical reactivity and local anesthetic effect in the parethoxycaine series. 22].	1968 May	5755894

Patents

Sample Use Guides

In Vivo Use Guide

5% rectal intracaine-oil mixture for caudal anesthesia and analgesia in rectal surgery

Route of Administration: Other

In Vitro Use Guide

Unknown

Name

Type

Language

PARETHOXYCAINE

Official Name

English

Parethoxycaine [WHO-DD]

Common Name

English

PARETHOXYCAINE [MI]

Common Name

English

parethoxycaine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C245